PRPF4

 

Full name: pre-mRNA processing factor 4 Alias Symbol: Prp4p|HPRP4|HPRP4P|PRP4|SNRNP60
Type: protein-coding gene Cytoband: 9q32
Entrez ID: 9128 HGNC ID: HGNC:17349 Ensembl Gene: ENSG00000136875 OMIM ID: 607795
Drug and gene relationship at DGIdb

 

Expression of PRPF4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRPF4 9128 209161_at 0.5164 0.0628
GSE20347 PRPF4 9128 209161_at 0.6727 0.0010
GSE23400 PRPF4 9128 209161_at 0.9922 0.0000
GSE26886 PRPF4 9128 209161_at 1.0876 0.0002
GSE29001 PRPF4 9128 209161_at 1.0266 0.0079
GSE38129 PRPF4 9128 209161_at 0.9030 0.0000
GSE45670 PRPF4 9128 209161_at 0.7070 0.0028
GSE53622 PRPF4 9128 93973 0.8214 0.0000
GSE53624 PRPF4 9128 93973 0.8932 0.0000
GSE63941 PRPF4 9128 209161_at 1.3493 0.0008
GSE77861 PRPF4 9128 209161_at 0.9410 0.0008
GSE97050 PRPF4 9128 A_23_P60537 0.7387 0.1222
SRP007169 PRPF4 9128 RNAseq 1.9955 0.0000
SRP008496 PRPF4 9128 RNAseq 1.9781 0.0000
SRP064894 PRPF4 9128 RNAseq 0.9746 0.0000
SRP133303 PRPF4 9128 RNAseq 0.8352 0.0000
SRP159526 PRPF4 9128 RNAseq 1.6076 0.0004
SRP193095 PRPF4 9128 RNAseq 0.6567 0.0000
SRP219564 PRPF4 9128 RNAseq 0.5187 0.0657
TCGA PRPF4 9128 RNAseq 0.2922 0.0000

Upregulated datasets: 6; Downregulated datasets: 0.  

 

Survival by PRPF4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRPF4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRPF4 9128 5 10 15
GSE20123 PRPF4 9128 5 10 15
GSE43470 PRPF4 9128 4 3 36
GSE46452 PRPF4 9128 6 13 40
GSE47630 PRPF4 9128 3 16 21
GSE54993 PRPF4 9128 3 3 64
GSE54994 PRPF4 9128 9 10 34
GSE60625 PRPF4 9128 0 0 11
GSE74703 PRPF4 9128 4 3 29
GSE74704 PRPF4 9128 2 8 10
TCGA PRPF4 9128 26 22 48

Total number of gains: 67; Total number of losses: 98; Total Number of normals: 323.  

 

Somatic mutations of PRPF4:

 

Generating mutation plots.

 

Highly correlated genes for PRPF4:

 

Showing top 20/1625 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRPF4DTD20.759625404
PRPF4SLC44A10.740828808
PRPF4KPNA20.737907908
PRPF4SAPCD20.732418606
PRPF4UBE2J20.731332303
PRPF4FAM89A0.731132303
PRPF4EME10.727862606
PRPF4ITPR30.72619112012
PRPF4NEK20.72609711011
PRPF4ACLY0.72325310010
PRPF4CENPF0.72021512012
PRPF4CEP550.71996812011
PRPF4PSME40.71865511011
PRPF4MCM60.71824313012
PRPF4IMP40.71253312012
PRPF4CDC200.71224310010
PRPF4AURKB0.71182412011
PRPF4ACTL6A0.71153113013
PRPF4CCDC860.708652908
PRPF4RFC40.70758213012

For details and further investigation, click here