Full name: caspase 2 | Alias Symbol: ICH1|PPP1R57|MGC2181 | ||
Type: protein-coding gene | Cytoband: 7q34 | ||
Entrez ID: 835 | HGNC ID: HGNC:1503 | Ensembl Gene: ENSG00000106144 | OMIM ID: 600639 |
Drug and gene relationship at DGIdb |
CASP2 involved pathways:
KEGG pathway | Description | View |
---|---|---|
hsa04210 | Apoptosis |
Expression of CASP2:
Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
---|---|---|---|---|---|---|
GSE17351 | CASP2 | 835 | 226032_at | 0.5386 | 0.4223 | |
GSE20347 | CASP2 | 835 | 209812_x_at | 0.1920 | 0.0069 | |
GSE23400 | CASP2 | 835 | 209811_at | 0.0242 | 0.5884 | |
GSE26886 | CASP2 | 835 | 226032_at | -0.3674 | 0.0536 | |
GSE29001 | CASP2 | 835 | 209811_at | -0.0565 | 0.8910 | |
GSE38129 | CASP2 | 835 | 209811_at | 0.4986 | 0.0407 | |
GSE45670 | CASP2 | 835 | 226032_at | 0.4577 | 0.0010 | |
GSE53622 | CASP2 | 835 | 15126 | 0.6116 | 0.0000 | |
GSE53624 | CASP2 | 835 | 60748 | 0.3904 | 0.0000 | |
GSE63941 | CASP2 | 835 | 226032_at | 0.3612 | 0.3520 | |
GSE77861 | CASP2 | 835 | 226032_at | 0.3277 | 0.0792 | |
GSE97050 | CASP2 | 835 | A_33_P3308387 | 0.6187 | 0.1378 | |
SRP007169 | CASP2 | 835 | RNAseq | 0.8892 | 0.0273 | |
SRP008496 | CASP2 | 835 | RNAseq | 0.8513 | 0.0008 | |
SRP064894 | CASP2 | 835 | RNAseq | 0.5159 | 0.0029 | |
SRP133303 | CASP2 | 835 | RNAseq | 0.5441 | 0.0074 | |
SRP159526 | CASP2 | 835 | RNAseq | 0.3801 | 0.0850 | |
SRP193095 | CASP2 | 835 | RNAseq | 0.3085 | 0.0053 | |
SRP219564 | CASP2 | 835 | RNAseq | 0.2882 | 0.4306 | |
TCGA | CASP2 | 835 | RNAseq | 0.2383 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CASP2 expression:
Note: Click image to view full size file.
Copy number change of CASP2:
Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
---|---|---|---|---|---|---|
GSE15526 | CASP2 | 835 | 4 | 2 | 24 | |
GSE20123 | CASP2 | 835 | 4 | 2 | 24 | |
GSE43470 | CASP2 | 835 | 3 | 4 | 36 | |
GSE46452 | CASP2 | 835 | 7 | 2 | 50 | |
GSE47630 | CASP2 | 835 | 6 | 7 | 27 | |
GSE54993 | CASP2 | 835 | 3 | 4 | 63 | |
GSE54994 | CASP2 | 835 | 5 | 8 | 40 | |
GSE60625 | CASP2 | 835 | 0 | 0 | 11 | |
GSE74703 | CASP2 | 835 | 2 | 4 | 30 | |
GSE74704 | CASP2 | 835 | 2 | 2 | 16 | |
TCGA | CASP2 | 835 | 28 | 25 | 43 |
Total number of gains: 64; Total number of losses: 60; Total Number of normals: 364.
Somatic mutations of CASP2:
Generating mutation plots.
Highly correlated genes for CASP2:
Showing top 20/434 corelated genes with mean PCC>0.5.
Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
---|---|---|---|---|---|
CASP2 | UBE2J2 | 0.726855 | 3 | 0 | 3 |
CASP2 | RCC2 | 0.723982 | 6 | 0 | 5 |
CASP2 | EZH2 | 0.710934 | 8 | 0 | 7 |
CASP2 | PPP1CA | 0.695379 | 3 | 0 | 3 |
CASP2 | SLC35B3 | 0.681043 | 3 | 0 | 3 |
CASP2 | KIF11 | 0.679968 | 6 | 0 | 5 |
CASP2 | SLC25A40 | 0.679705 | 3 | 0 | 3 |
CASP2 | KIAA1522 | 0.674227 | 4 | 0 | 3 |
CASP2 | DUS3L | 0.671777 | 4 | 0 | 4 |
CASP2 | SLC1A5 | 0.670532 | 4 | 0 | 3 |
CASP2 | ATR | 0.670302 | 6 | 0 | 6 |
CASP2 | ABRACL | 0.659605 | 4 | 0 | 4 |
CASP2 | BUB3 | 0.657744 | 4 | 0 | 4 |
CASP2 | AAMP | 0.657681 | 3 | 0 | 3 |
CASP2 | PDIK1L | 0.657023 | 3 | 0 | 3 |
CASP2 | ZWILCH | 0.654494 | 5 | 0 | 4 |
CASP2 | GTF2A1 | 0.653159 | 3 | 0 | 3 |
CASP2 | CCDC117 | 0.65166 | 3 | 0 | 3 |
CASP2 | CLN6 | 0.642902 | 4 | 0 | 4 |
CASP2 | MFSD3 | 0.642543 | 3 | 0 | 3 |
For details and further investigation, click here