CASP2

 

Full name: caspase 2 Alias Symbol: ICH1|PPP1R57|MGC2181
Type: protein-coding gene Cytoband: 7q34
Entrez ID: 835 HGNC ID: HGNC:1503 Ensembl Gene: ENSG00000106144 OMIM ID: 600639
Drug and gene relationship at DGIdb

 

CASP2 involved pathways:

KEGG pathway Description View
hsa04210Apoptosis

 

Expression of CASP2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CASP2 835 226032_at 0.5386 0.4223
GSE20347 CASP2 835 209812_x_at 0.1920 0.0069
GSE23400 CASP2 835 209811_at 0.0242 0.5884
GSE26886 CASP2 835 226032_at -0.3674 0.0536
GSE29001 CASP2 835 209811_at -0.0565 0.8910
GSE38129 CASP2 835 209811_at 0.4986 0.0407
GSE45670 CASP2 835 226032_at 0.4577 0.0010
GSE53622 CASP2 835 15126 0.6116 0.0000
GSE53624 CASP2 835 60748 0.3904 0.0000
GSE63941 CASP2 835 226032_at 0.3612 0.3520
GSE77861 CASP2 835 226032_at 0.3277 0.0792
GSE97050 CASP2 835 A_33_P3308387 0.6187 0.1378
SRP007169 CASP2 835 RNAseq 0.8892 0.0273
SRP008496 CASP2 835 RNAseq 0.8513 0.0008
SRP064894 CASP2 835 RNAseq 0.5159 0.0029
SRP133303 CASP2 835 RNAseq 0.5441 0.0074
SRP159526 CASP2 835 RNAseq 0.3801 0.0850
SRP193095 CASP2 835 RNAseq 0.3085 0.0053
SRP219564 CASP2 835 RNAseq 0.2882 0.4306
TCGA CASP2 835 RNAseq 0.2383 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CASP2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CASP2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CASP2 835 4 2 24
GSE20123 CASP2 835 4 2 24
GSE43470 CASP2 835 3 4 36
GSE46452 CASP2 835 7 2 50
GSE47630 CASP2 835 6 7 27
GSE54993 CASP2 835 3 4 63
GSE54994 CASP2 835 5 8 40
GSE60625 CASP2 835 0 0 11
GSE74703 CASP2 835 2 4 30
GSE74704 CASP2 835 2 2 16
TCGA CASP2 835 28 25 43

Total number of gains: 64; Total number of losses: 60; Total Number of normals: 364.  

 

Somatic mutations of CASP2:

 

Generating mutation plots.

 

Highly correlated genes for CASP2:

 

Showing top 20/434 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CASP2UBE2J20.726855303
CASP2RCC20.723982605
CASP2EZH20.710934807
CASP2PPP1CA0.695379303
CASP2SLC35B30.681043303
CASP2KIF110.679968605
CASP2SLC25A400.679705303
CASP2KIAA15220.674227403
CASP2DUS3L0.671777404
CASP2SLC1A50.670532403
CASP2ATR0.670302606
CASP2ABRACL0.659605404
CASP2BUB30.657744404
CASP2AAMP0.657681303
CASP2PDIK1L0.657023303
CASP2ZWILCH0.654494504
CASP2GTF2A10.653159303
CASP2CCDC1170.65166303
CASP2CLN60.642902404
CASP2MFSD30.642543303

For details and further investigation, click here