Full name: protein phosphatase 3 regulatory subunit B, alpha	Alias Symbol: CALNB1|CNB|CNB1
Type: protein-coding gene	Cytoband: 2p14
Entrez ID: 5534	HGNC ID: HGNC:9317	Ensembl Gene: ENSG00000221823	OMIM ID: 601302
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 17/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

---

 

PPP3R1 involved pathways:

KEGG pathway	Description	View
hsa04010	MAPK signaling pathway	View
hsa04020	Calcium signaling pathway	View
hsa04022	cGMP-PKG signaling pathway	View
hsa04114	Oocyte meiosis	View
hsa04310	Wnt signaling pathway	View
hsa04360	Axon guidance	View
hsa04370	VEGF signaling pathway	View
hsa04380	Osteoclast differentiation	View
hsa04650	Natural killer cell mediated cytotoxicity	View
hsa04660	T cell receptor signaling pathway	View
hsa04662	B cell receptor signaling pathway	View
hsa04720	Long-term potentiation	View
hsa04724	Glutamatergic synapse	View
hsa04921	Oxytocin signaling pathway	View
hsa04922	Glucagon signaling pathway	View
hsa04924	Renin secretion	View
hsa05010	Alzheimer's disease	View
hsa05014	Amyotrophic lateral sclerosis (ALS)	View
hsa05031	Amphetamine addiction	View
hsa05152	Tuberculosis	View
hsa05166	HTLV-I infection	View

---

 

Expression of PPP3R1:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	PPP3R1	5534	204506_at	0.2143	0.6321	Show
GSE20347	PPP3R1	5534	204506_at	-0.0531	0.6408	Show
GSE23400	PPP3R1	5534	204506_at	0.0678	0.4779	Show
GSE26886	PPP3R1	5534	204506_at	-0.7471	0.0000	Show
GSE29001	PPP3R1	5534	204506_at	-0.1252	0.6058	Show
GSE38129	PPP3R1	5534	204506_at	0.1236	0.7077	Show
GSE45670	PPP3R1	5534	204506_at	-0.1388	0.3217	Show
GSE53622	PPP3R1	5534	4603	0.1527	0.0030	Show
GSE53624	PPP3R1	5534	4603	0.0357	0.5958	Show
GSE63941	PPP3R1	5534	204507_s_at	-1.8526	0.0230	Show
GSE77861	PPP3R1	5534	204506_at	0.1853	0.2702	Show
GSE97050	PPP3R1	5534	A_33_P3214293	0.3968	0.2571	Show
SRP007169	PPP3R1	5534	RNAseq	-0.2025	0.6286	Show
SRP008496	PPP3R1	5534	RNAseq	-0.1497	0.5336	Show
SRP064894	PPP3R1	5534	RNAseq	0.0815	0.5928	Show
SRP133303	PPP3R1	5534	RNAseq	0.3109	0.0326	Show
SRP159526	PPP3R1	5534	RNAseq	0.2504	0.2591	Show
SRP193095	PPP3R1	5534	RNAseq	0.0084	0.9170	Show
SRP219564	PPP3R1	5534	RNAseq	0.0077	0.9720	Show
TCGA	PPP3R1	5534	RNAseq	0.0984	0.0328	Show

Upregulated datasets: 0; Downregulated datasets: 1.  Download Data

---

 

Survival by PPP3R1 expression:

 

---

Copy number change of PPP3R1:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	PPP3R1	5534	11	0	19	Show
GSE20123	PPP3R1	5534	11	0	19	Show
GSE43470	PPP3R1	5534	6	0	37	Show
GSE46452	PPP3R1	5534	2	3	54	Show
GSE47630	PPP3R1	5534	7	0	33	Show
GSE54993	PPP3R1	5534	0	6	64	Show
GSE54994	PPP3R1	5534	12	0	41	Show
GSE60625	PPP3R1	5534	0	3	8	Show
GSE74703	PPP3R1	5534	6	0	30	Show
GSE74704	PPP3R1	5534	9	0	11	Show
TCGA	PPP3R1	5534	36	2	58	Show

Total number of gains: 100; Total number of losses: 14; Total Number of normals: 374.  Download Data

---

 

Somatic mutations of PPP3R1:

 

---

 

Highly correlated genes for PPP3R1:

 

Showing top 20/107 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
PPP3R1	TIMM17A	0.69245	3	0	3
PPP3R1	TAF15	0.681745	3	0	3
PPP3R1	CLN8	0.655905	3	0	3
PPP3R1	FLNB	0.649951	3	0	3
PPP3R1	GLUD2	0.631626	3	0	3
PPP3R1	ZMPSTE24	0.631482	3	0	3
PPP3R1	PLK2	0.630685	3	0	3
PPP3R1	TUBB3	0.630616	3	0	3
PPP3R1	C16orf87	0.628258	4	0	3
PPP3R1	LRRC8A	0.627982	3	0	3
PPP3R1	SPCS2	0.624834	3	0	3
PPP3R1	SYMPK	0.622776	3	0	3
PPP3R1	NPC1	0.62115	4	0	3
PPP3R1	GFPT1	0.612963	5	0	3
PPP3R1	ACTR3	0.612599	4	0	3
PPP3R1	TFRC	0.607693	3	0	3
PPP3R1	NEK1	0.606656	4	0	3
PPP3R1	CEPT1	0.600952	4	0	3
PPP3R1	MTMR3	0.593387	3	0	3
PPP3R1	YIPF4	0.593137	5	0	4

For details and further investigation, click here