| Full name: peroxiredoxin 1 | Alias Symbol: NKEFA | ||
| Type: protein-coding gene | Cytoband: 1p34.1 | ||
| Entrez ID: 5052 | HGNC ID: HGNC:9352 | Ensembl Gene: ENSG00000117450 | OMIM ID: 176763 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PRDX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRDX1 | 5052 | 208680_at | 0.1205 | 0.6984 | |
| GSE20347 | PRDX1 | 5052 | 208680_at | -0.0529 | 0.6843 | |
| GSE23400 | PRDX1 | 5052 | 208680_at | 0.0451 | 0.6585 | |
| GSE26886 | PRDX1 | 5052 | 208680_at | -0.8702 | 0.0004 | |
| GSE29001 | PRDX1 | 5052 | 208680_at | -0.6349 | 0.1030 | |
| GSE38129 | PRDX1 | 5052 | 208680_at | 0.2056 | 0.2043 | |
| GSE45670 | PRDX1 | 5052 | 208680_at | 0.0486 | 0.7245 | |
| GSE53622 | PRDX1 | 5052 | 894 | -0.1801 | 0.0558 | |
| GSE53624 | PRDX1 | 5052 | 894 | -0.0058 | 0.9495 | |
| GSE63941 | PRDX1 | 5052 | 208680_at | 0.4068 | 0.2472 | |
| GSE77861 | PRDX1 | 5052 | 208680_at | -0.1069 | 0.7793 | |
| GSE97050 | PRDX1 | 5052 | A_33_P3377199 | -0.2593 | 0.3673 | |
| SRP007169 | PRDX1 | 5052 | RNAseq | -1.0498 | 0.0160 | |
| SRP008496 | PRDX1 | 5052 | RNAseq | -1.0835 | 0.0011 | |
| SRP064894 | PRDX1 | 5052 | RNAseq | -0.5998 | 0.0020 | |
| SRP133303 | PRDX1 | 5052 | RNAseq | -0.3343 | 0.1417 | |
| SRP159526 | PRDX1 | 5052 | RNAseq | 0.2268 | 0.6208 | |
| SRP193095 | PRDX1 | 5052 | RNAseq | -0.3907 | 0.0846 | |
| SRP219564 | PRDX1 | 5052 | RNAseq | -0.4509 | 0.3681 | |
| TCGA | PRDX1 | 5052 | RNAseq | 0.2049 | 0.0004 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PRDX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRDX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRDX1 | 5052 | 4 | 3 | 23 | |
| GSE20123 | PRDX1 | 5052 | 4 | 2 | 24 | |
| GSE43470 | PRDX1 | 5052 | 7 | 2 | 34 | |
| GSE46452 | PRDX1 | 5052 | 2 | 1 | 56 | |
| GSE47630 | PRDX1 | 5052 | 9 | 3 | 28 | |
| GSE54993 | PRDX1 | 5052 | 0 | 1 | 69 | |
| GSE54994 | PRDX1 | 5052 | 12 | 2 | 39 | |
| GSE60625 | PRDX1 | 5052 | 0 | 0 | 11 | |
| GSE74703 | PRDX1 | 5052 | 6 | 1 | 29 | |
| GSE74704 | PRDX1 | 5052 | 2 | 0 | 18 | |
| TCGA | PRDX1 | 5052 | 11 | 16 | 69 |
Total number of gains: 57; Total number of losses: 31; Total Number of normals: 400.
Somatic mutations of PRDX1:
Generating mutation plots.
Highly correlated genes for PRDX1:
Showing top 20/402 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRDX1 | S100A16 | 0.762954 | 3 | 0 | 3 |
| PRDX1 | TMEM79 | 0.762432 | 3 | 0 | 3 |
| PRDX1 | A2ML1 | 0.709063 | 3 | 0 | 3 |
| PRDX1 | BNIPL | 0.704518 | 3 | 0 | 3 |
| PRDX1 | CNFN | 0.699821 | 3 | 0 | 3 |
| PRDX1 | DNAJC5 | 0.698631 | 3 | 0 | 3 |
| PRDX1 | ABO | 0.695018 | 3 | 0 | 3 |
| PRDX1 | GDPD3 | 0.692487 | 3 | 0 | 3 |
| PRDX1 | C6orf132 | 0.689319 | 3 | 0 | 3 |
| PRDX1 | EPS8L1 | 0.679297 | 3 | 0 | 3 |
| PRDX1 | SYTL1 | 0.676154 | 3 | 0 | 3 |
| PRDX1 | GSTP1 | 0.675391 | 8 | 0 | 6 |
| PRDX1 | CDYL | 0.6699 | 3 | 0 | 3 |
| PRDX1 | DUOX1 | 0.665318 | 4 | 0 | 3 |
| PRDX1 | HM13 | 0.661791 | 4 | 0 | 3 |
| PRDX1 | LIPH | 0.656948 | 3 | 0 | 3 |
| PRDX1 | FAM160A1 | 0.656354 | 4 | 0 | 4 |
| PRDX1 | TMEM40 | 0.652759 | 4 | 0 | 4 |
| PRDX1 | C10orf99 | 0.652242 | 3 | 0 | 3 |
| PRDX1 | RNF39 | 0.650704 | 3 | 0 | 3 |
For details and further investigation, click here
