PRIM1

 

Full name: DNA primase subunit 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 12q13.3
Entrez ID: 5557 HGNC ID: HGNC:9369 Ensembl Gene: ENSG00000198056 OMIM ID: 176635
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of PRIM1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRIM1 5557 205053_at 0.3965 0.4175
GSE20347 PRIM1 5557 205053_at 0.7728 0.0003
GSE23400 PRIM1 5557 205053_at 0.3702 0.0000
GSE26886 PRIM1 5557 205053_at 0.5277 0.0585
GSE29001 PRIM1 5557 205053_at 0.6991 0.1195
GSE38129 PRIM1 5557 205053_at 0.9579 0.0000
GSE45670 PRIM1 5557 205053_at 0.7015 0.0035
GSE53622 PRIM1 5557 2078 0.7670 0.0000
GSE53624 PRIM1 5557 2078 1.1809 0.0000
GSE63941 PRIM1 5557 205053_at 3.4156 0.0000
GSE77861 PRIM1 5557 205053_at 0.4062 0.0783
GSE97050 PRIM1 5557 A_23_P25019 0.8254 0.1496
SRP007169 PRIM1 5557 RNAseq 0.7874 0.0907
SRP008496 PRIM1 5557 RNAseq 0.8535 0.0163
SRP064894 PRIM1 5557 RNAseq 0.9300 0.0001
SRP133303 PRIM1 5557 RNAseq 0.9100 0.0000
SRP159526 PRIM1 5557 RNAseq 0.6927 0.0262
SRP193095 PRIM1 5557 RNAseq 0.4355 0.0012
SRP219564 PRIM1 5557 RNAseq 0.6542 0.1360
TCGA PRIM1 5557 RNAseq 0.7313 0.0000

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by PRIM1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRIM1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRIM1 5557 7 2 21
GSE20123 PRIM1 5557 7 1 22
GSE43470 PRIM1 5557 3 0 40
GSE46452 PRIM1 5557 8 1 50
GSE47630 PRIM1 5557 10 2 28
GSE54993 PRIM1 5557 0 5 65
GSE54994 PRIM1 5557 4 1 48
GSE60625 PRIM1 5557 0 0 11
GSE74703 PRIM1 5557 3 0 33
GSE74704 PRIM1 5557 4 1 15
TCGA PRIM1 5557 14 10 72

Total number of gains: 60; Total number of losses: 23; Total Number of normals: 405.  

 

Somatic mutations of PRIM1:

 

Generating mutation plots.

 

Highly correlated genes for PRIM1:

 

Showing top 20/1638 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRIM1MMS22L0.774641303
PRIM1CCNB20.75660612012
PRIM1CKAP2L0.751882707
PRIM1RPA30.74327713012
PRIM1MCM60.74070113013
PRIM1GMNN0.73736913013
PRIM1KIF150.73622111011
PRIM1TPX20.73535813013
PRIM1HMMR0.73322213012
PRIM1CKS1B0.73214912012
PRIM1CDT10.73206311011
PRIM1TNFAIP80.730349303
PRIM1PCNA0.72132513012
PRIM1FBXO50.72080712011
PRIM1UBL7-AS10.720689505
PRIM1RMI20.719001707
PRIM1MAD2L10.71779812011
PRIM1CHEK10.71716613012
PRIM1KIF18A0.71699212011
PRIM1PBK0.71646913013

For details and further investigation, click here