| Full name: serine protease 21 | Alias Symbol: ESP-1|TEST1 | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 10942 | HGNC ID: HGNC:9485 | Ensembl Gene: ENSG00000007038 | OMIM ID: 608159 |
| Drug and gene relationship at DGIdb | |||
Expression of PRSS21:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRSS21 | 10942 | 220051_at | 1.4858 | 0.1406 | |
| GSE20347 | PRSS21 | 10942 | 220051_at | 0.9616 | 0.0155 | |
| GSE23400 | PRSS21 | 10942 | 220051_at | 0.7666 | 0.0000 | |
| GSE26886 | PRSS21 | 10942 | 220051_at | 1.3954 | 0.0002 | |
| GSE29001 | PRSS21 | 10942 | 220051_at | 0.5481 | 0.2233 | |
| GSE38129 | PRSS21 | 10942 | 220051_at | 1.2582 | 0.0003 | |
| GSE45670 | PRSS21 | 10942 | 220051_at | 1.3611 | 0.0127 | |
| GSE53622 | PRSS21 | 10942 | 79408 | 1.9197 | 0.0000 | |
| GSE53624 | PRSS21 | 10942 | 79408 | 1.7585 | 0.0000 | |
| GSE63941 | PRSS21 | 10942 | 220051_at | 2.8472 | 0.2167 | |
| GSE77861 | PRSS21 | 10942 | 220051_at | 0.3587 | 0.3724 | |
| GSE97050 | PRSS21 | 10942 | A_24_P339126 | 1.2562 | 0.1131 | |
| SRP007169 | PRSS21 | 10942 | RNAseq | 4.5960 | 0.0000 | |
| SRP133303 | PRSS21 | 10942 | RNAseq | 2.8449 | 0.0000 | |
| TCGA | PRSS21 | 10942 | RNAseq | 2.1305 | 0.0002 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by PRSS21 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRSS21:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRSS21 | 10942 | 5 | 5 | 20 | |
| GSE20123 | PRSS21 | 10942 | 5 | 4 | 21 | |
| GSE43470 | PRSS21 | 10942 | 4 | 7 | 32 | |
| GSE46452 | PRSS21 | 10942 | 38 | 1 | 20 | |
| GSE47630 | PRSS21 | 10942 | 13 | 6 | 21 | |
| GSE54993 | PRSS21 | 10942 | 3 | 5 | 62 | |
| GSE54994 | PRSS21 | 10942 | 5 | 9 | 39 | |
| GSE60625 | PRSS21 | 10942 | 4 | 0 | 7 | |
| GSE74703 | PRSS21 | 10942 | 4 | 5 | 27 | |
| GSE74704 | PRSS21 | 10942 | 3 | 2 | 15 | |
| TCGA | PRSS21 | 10942 | 19 | 13 | 64 |
Total number of gains: 103; Total number of losses: 57; Total Number of normals: 328.
Somatic mutations of PRSS21:
Generating mutation plots.
Highly correlated genes for PRSS21:
Showing top 20/189 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRSS21 | NOB1 | 0.747313 | 3 | 0 | 3 |
| PRSS21 | NKX2-2 | 0.717289 | 3 | 0 | 3 |
| PRSS21 | ZIC2 | 0.675485 | 3 | 0 | 3 |
| PRSS21 | TFR2 | 0.650849 | 3 | 0 | 3 |
| PRSS21 | KCNQ5 | 0.626678 | 5 | 0 | 3 |
| PRSS21 | ATAD3B | 0.626533 | 3 | 0 | 3 |
| PRSS21 | GEMIN4 | 0.619377 | 5 | 0 | 3 |
| PRSS21 | PGP | 0.61192 | 3 | 0 | 3 |
| PRSS21 | SERPINA9 | 0.610996 | 3 | 0 | 3 |
| PRSS21 | CHTF18 | 0.605534 | 5 | 0 | 3 |
| PRSS21 | DUS1L | 0.603075 | 4 | 0 | 3 |
| PRSS21 | SMKR1 | 0.602708 | 5 | 0 | 3 |
| PRSS21 | HMBS | 0.599109 | 4 | 0 | 3 |
| PRSS21 | WDR34 | 0.596747 | 4 | 0 | 3 |
| PRSS21 | TTC9C | 0.593411 | 5 | 0 | 3 |
| PRSS21 | SIPA1L3 | 0.589618 | 5 | 0 | 3 |
| PRSS21 | OGFOD2 | 0.58946 | 4 | 0 | 4 |
| PRSS21 | EDARADD | 0.588369 | 4 | 0 | 3 |
| PRSS21 | TTYH3 | 0.588339 | 5 | 0 | 3 |
| PRSS21 | DHRS13 | 0.587496 | 4 | 0 | 3 |
For details and further investigation, click here
