| Full name: adenosylmethionine decarboxylase 1 | Alias Symbol: SAMDC | ||
| Type: protein-coding gene | Cytoband: 6q21 | ||
| Entrez ID: 262 | HGNC ID: HGNC:457 | Ensembl Gene: ENSG00000123505 | OMIM ID: 180980 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of AMD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AMD1 | 262 | 201197_at | -0.0290 | 0.9632 | |
| GSE20347 | AMD1 | 262 | 201196_s_at | -0.3387 | 0.0473 | |
| GSE23400 | AMD1 | 262 | 201196_s_at | 0.1438 | 0.1032 | |
| GSE26886 | AMD1 | 262 | 201196_s_at | -0.5218 | 0.0082 | |
| GSE29001 | AMD1 | 262 | 201196_s_at | -0.1091 | 0.7439 | |
| GSE38129 | AMD1 | 262 | 201197_at | -0.3524 | 0.0006 | |
| GSE45670 | AMD1 | 262 | 201197_at | -0.0842 | 0.5566 | |
| GSE53622 | AMD1 | 262 | 95677 | -0.4300 | 0.0000 | |
| GSE53624 | AMD1 | 262 | 82313 | -0.7307 | 0.0000 | |
| GSE63941 | AMD1 | 262 | 201196_s_at | 1.3717 | 0.0038 | |
| GSE77861 | AMD1 | 262 | 201196_s_at | -0.1904 | 0.6802 | |
| GSE97050 | AMD1 | 262 | A_24_P371962 | -0.6310 | 0.0706 | |
| SRP007169 | AMD1 | 262 | RNAseq | -0.6452 | 0.0714 | |
| SRP008496 | AMD1 | 262 | RNAseq | -0.6551 | 0.0003 | |
| SRP064894 | AMD1 | 262 | RNAseq | -0.6039 | 0.0004 | |
| SRP133303 | AMD1 | 262 | RNAseq | -0.2495 | 0.1384 | |
| SRP159526 | AMD1 | 262 | RNAseq | -0.5775 | 0.0041 | |
| SRP193095 | AMD1 | 262 | RNAseq | -0.7118 | 0.0000 | |
| SRP219564 | AMD1 | 262 | RNAseq | -0.5030 | 0.1242 | |
| TCGA | AMD1 | 262 | RNAseq | -0.1070 | 0.0123 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by AMD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AMD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AMD1 | 262 | 2 | 3 | 25 | |
| GSE20123 | AMD1 | 262 | 2 | 3 | 25 | |
| GSE43470 | AMD1 | 262 | 3 | 1 | 39 | |
| GSE46452 | AMD1 | 262 | 2 | 11 | 46 | |
| GSE47630 | AMD1 | 262 | 9 | 4 | 27 | |
| GSE54993 | AMD1 | 262 | 3 | 2 | 65 | |
| GSE54994 | AMD1 | 262 | 8 | 8 | 37 | |
| GSE60625 | AMD1 | 262 | 0 | 2 | 9 | |
| GSE74703 | AMD1 | 262 | 2 | 1 | 33 | |
| GSE74704 | AMD1 | 262 | 0 | 1 | 19 | |
| TCGA | AMD1 | 262 | 6 | 23 | 67 |
Total number of gains: 37; Total number of losses: 59; Total Number of normals: 392.
Somatic mutations of AMD1:
Generating mutation plots.
Highly correlated genes for AMD1:
Showing top 20/474 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AMD1 | C2orf49 | 0.774723 | 3 | 0 | 3 |
| AMD1 | TYW3 | 0.762775 | 3 | 0 | 3 |
| AMD1 | MRTO4 | 0.736521 | 3 | 0 | 3 |
| AMD1 | UQCR11 | 0.73576 | 3 | 0 | 3 |
| AMD1 | PIK3C2A | 0.726083 | 3 | 0 | 3 |
| AMD1 | C1orf56 | 0.709693 | 3 | 0 | 3 |
| AMD1 | MRPL42 | 0.704925 | 5 | 0 | 4 |
| AMD1 | MATR3 | 0.703339 | 4 | 0 | 3 |
| AMD1 | ZCCHC9 | 0.702957 | 3 | 0 | 3 |
| AMD1 | DLD | 0.700354 | 4 | 0 | 3 |
| AMD1 | PWP1 | 0.695501 | 3 | 0 | 3 |
| AMD1 | MFAP1 | 0.695287 | 4 | 0 | 3 |
| AMD1 | RPF1 | 0.687001 | 4 | 0 | 4 |
| AMD1 | MRPS11 | 0.685524 | 4 | 0 | 3 |
| AMD1 | COPS2 | 0.68031 | 4 | 0 | 3 |
| AMD1 | KCNJ15 | 0.678788 | 3 | 0 | 3 |
| AMD1 | GSTZ1 | 0.671846 | 4 | 0 | 3 |
| AMD1 | CA13 | 0.670154 | 3 | 0 | 3 |
| AMD1 | UTRN | 0.66972 | 3 | 0 | 3 |
| AMD1 | SRFBP1 | 0.666851 | 4 | 0 | 4 |
For details and further investigation, click here
