RFC1

 

Full name: replication factor C subunit 1 Alias Symbol: A1|PO-GA|RFC140|MHCBFB
Type: protein-coding gene Cytoband: 4p14
Entrez ID: 5981 HGNC ID: HGNC:9969 Ensembl Gene: ENSG00000035928 OMIM ID: 102579
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 146/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of RFC1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RFC1 5981 209085_x_at 0.1441 0.8219
GSE20347 RFC1 5981 209085_x_at 0.0530 0.7455
GSE23400 RFC1 5981 208021_s_at 0.1554 0.0159
GSE26886 RFC1 5981 209085_x_at 0.2266 0.3479
GSE29001 RFC1 5981 209085_x_at 0.5376 0.0698
GSE38129 RFC1 5981 209085_x_at 0.2352 0.0799
GSE45670 RFC1 5981 209085_x_at 0.0028 0.9861
GSE53622 RFC1 5981 135664 0.1564 0.0321
GSE53624 RFC1 5981 135664 0.2951 0.0005
GSE63941 RFC1 5981 209085_x_at 0.6570 0.0385
GSE77861 RFC1 5981 208021_s_at 0.2091 0.3087
GSE97050 RFC1 5981 A_23_P18465 -0.0987 0.6120
SRP007169 RFC1 5981 RNAseq 1.0041 0.0102
SRP008496 RFC1 5981 RNAseq 0.8948 0.0001
SRP064894 RFC1 5981 RNAseq 0.1699 0.2696
SRP133303 RFC1 5981 RNAseq 0.0047 0.9721
SRP159526 RFC1 5981 RNAseq 0.0597 0.7748
SRP193095 RFC1 5981 RNAseq -0.0279 0.7538
SRP219564 RFC1 5981 RNAseq -0.0872 0.6712
TCGA RFC1 5981 RNAseq -0.0604 0.2182

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by RFC1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RFC1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RFC1 5981 0 16 14
GSE20123 RFC1 5981 0 16 14
GSE43470 RFC1 5981 0 15 28
GSE46452 RFC1 5981 1 36 22
GSE47630 RFC1 5981 1 19 20
GSE54993 RFC1 5981 8 0 62
GSE54994 RFC1 5981 3 10 40
GSE60625 RFC1 5981 0 0 11
GSE74703 RFC1 5981 0 12 24
GSE74704 RFC1 5981 0 9 11
TCGA RFC1 5981 11 45 40

Total number of gains: 24; Total number of losses: 178; Total Number of normals: 286.  

 

Somatic mutations of RFC1:

 

Generating mutation plots.

 

Highly correlated genes for RFC1:

 

Showing top 20/575 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RFC1PDK30.747273303
RFC1CINP0.723936303
RFC1CLP10.720766303
RFC1INTS100.706096303
RFC1AFAP1L20.701348303
RFC1FLNB0.696144403
RFC1ZNF6230.694096404
RFC1STAT5B0.691499303
RFC1NTN40.690776303
RFC1ASCC30.685239404
RFC1MYO3B0.682609303
RFC1LYPLAL10.677609303
RFC1MRPL350.667777303
RFC1SNF80.666605303
RFC1EIF2S10.66653303
RFC1MB21D20.666504504
RFC1FASTKD30.660235504
RFC1CLDN120.658656303
RFC1DONSON0.658013505
RFC1CCT50.657557403

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