| Full name: ubiquitin conjugating enzyme E2 D3 | Alias Symbol: UbcH5C | ||
| Type: protein-coding gene | Cytoband: 4q24 | ||
| Entrez ID: 7323 | HGNC ID: HGNC:12476 | Ensembl Gene: ENSG00000109332 | OMIM ID: 602963 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UBE2D3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UBE2D3 | 7323 | 200668_s_at | -0.0589 | 0.8657 | |
| GSE20347 | UBE2D3 | 7323 | 200668_s_at | -0.2113 | 0.1771 | |
| GSE23400 | UBE2D3 | 7323 | 200668_s_at | 0.0317 | 0.7045 | |
| GSE26886 | UBE2D3 | 7323 | 200668_s_at | -0.6772 | 0.0007 | |
| GSE29001 | UBE2D3 | 7323 | 200669_s_at | -0.5382 | 0.0180 | |
| GSE38129 | UBE2D3 | 7323 | 200668_s_at | -0.0535 | 0.6955 | |
| GSE45670 | UBE2D3 | 7323 | 200668_s_at | -0.0577 | 0.5354 | |
| GSE53622 | UBE2D3 | 7323 | 13061 | -0.1872 | 0.0002 | |
| GSE53624 | UBE2D3 | 7323 | 13061 | -0.3362 | 0.0000 | |
| GSE63941 | UBE2D3 | 7323 | 200668_s_at | 0.0183 | 0.9436 | |
| GSE77861 | UBE2D3 | 7323 | 200668_s_at | -0.2599 | 0.2959 | |
| GSE97050 | UBE2D3 | 7323 | A_23_P58293 | -0.1516 | 0.5442 | |
| SRP007169 | UBE2D3 | 7323 | RNAseq | -1.2027 | 0.0038 | |
| SRP008496 | UBE2D3 | 7323 | RNAseq | -1.1491 | 0.0000 | |
| SRP064894 | UBE2D3 | 7323 | RNAseq | -0.4916 | 0.0001 | |
| SRP133303 | UBE2D3 | 7323 | RNAseq | 0.1288 | 0.4485 | |
| SRP159526 | UBE2D3 | 7323 | RNAseq | -0.5915 | 0.0001 | |
| SRP193095 | UBE2D3 | 7323 | RNAseq | -0.4812 | 0.0001 | |
| SRP219564 | UBE2D3 | 7323 | RNAseq | -0.5330 | 0.0287 | |
| TCGA | UBE2D3 | 7323 | RNAseq | -0.0478 | 0.2414 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by UBE2D3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UBE2D3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UBE2D3 | 7323 | 0 | 12 | 18 | |
| GSE20123 | UBE2D3 | 7323 | 0 | 12 | 18 | |
| GSE43470 | UBE2D3 | 7323 | 0 | 13 | 30 | |
| GSE46452 | UBE2D3 | 7323 | 1 | 36 | 22 | |
| GSE47630 | UBE2D3 | 7323 | 0 | 20 | 20 | |
| GSE54993 | UBE2D3 | 7323 | 9 | 0 | 61 | |
| GSE54994 | UBE2D3 | 7323 | 1 | 10 | 42 | |
| GSE60625 | UBE2D3 | 7323 | 0 | 3 | 8 | |
| GSE74703 | UBE2D3 | 7323 | 0 | 11 | 25 | |
| GSE74704 | UBE2D3 | 7323 | 0 | 6 | 14 | |
| TCGA | UBE2D3 | 7323 | 8 | 39 | 49 |
Total number of gains: 19; Total number of losses: 162; Total Number of normals: 307.
Somatic mutations of UBE2D3:
Generating mutation plots.
Highly correlated genes for UBE2D3:
Showing top 20/238 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UBE2D3 | SEC11C | 0.74056 | 3 | 0 | 3 |
| UBE2D3 | CCR2 | 0.666665 | 3 | 0 | 3 |
| UBE2D3 | SEC24A | 0.659856 | 4 | 0 | 4 |
| UBE2D3 | LAMTOR3 | 0.651347 | 10 | 0 | 8 |
| UBE2D3 | FUNDC1 | 0.648199 | 4 | 0 | 3 |
| UBE2D3 | GRAMD1C | 0.645561 | 3 | 0 | 3 |
| UBE2D3 | TMEM8A | 0.64496 | 3 | 0 | 3 |
| UBE2D3 | SMAGP | 0.636855 | 4 | 0 | 4 |
| UBE2D3 | NFKB1 | 0.629924 | 8 | 0 | 8 |
| UBE2D3 | SPTLC2 | 0.608565 | 4 | 0 | 3 |
| UBE2D3 | TAB3 | 0.607465 | 4 | 0 | 4 |
| UBE2D3 | CPM | 0.606181 | 3 | 0 | 3 |
| UBE2D3 | GLCE | 0.605892 | 5 | 0 | 5 |
| UBE2D3 | TIFA | 0.603857 | 5 | 0 | 4 |
| UBE2D3 | PSMD7 | 0.602425 | 4 | 0 | 3 |
| UBE2D3 | SERPINB3 | 0.599334 | 4 | 0 | 3 |
| UBE2D3 | MMADHC | 0.597116 | 8 | 0 | 5 |
| UBE2D3 | TRAF3IP3 | 0.595109 | 3 | 0 | 3 |
| UBE2D3 | PNRC2 | 0.594183 | 4 | 0 | 3 |
| UBE2D3 | PRSS2 | 0.592786 | 4 | 0 | 4 |
For details and further investigation, click here
