| Full name: SEH1 like nucleoporin | Alias Symbol: SEH1A|SEH1B|Seh1|SEC13L | ||
| Type: protein-coding gene | Cytoband: 18p11.21 | ||
| Entrez ID: 81929 | HGNC ID: HGNC:30379 | Ensembl Gene: ENSG00000085415 | OMIM ID: 609263 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
SEH1L involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04150 | mTOR signaling pathway |
Expression of SEH1L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEH1L | 81929 | 221931_s_at | 0.5066 | 0.4516 | |
| GSE20347 | SEH1L | 81929 | 221931_s_at | 0.1859 | 0.4007 | |
| GSE23400 | SEH1L | 81929 | 221931_s_at | 0.5119 | 0.0000 | |
| GSE26886 | SEH1L | 81929 | 221931_s_at | -0.3603 | 0.0966 | |
| GSE29001 | SEH1L | 81929 | 221931_s_at | 0.6222 | 0.0231 | |
| GSE38129 | SEH1L | 81929 | 221931_s_at | 0.5419 | 0.0013 | |
| GSE45670 | SEH1L | 81929 | 221931_s_at | 0.0335 | 0.8222 | |
| GSE53622 | SEH1L | 81929 | 61492 | -0.2028 | 0.0416 | |
| GSE53624 | SEH1L | 81929 | 61492 | 0.0492 | 0.5443 | |
| GSE63941 | SEH1L | 81929 | 221931_s_at | 0.5400 | 0.4015 | |
| GSE77861 | SEH1L | 81929 | 221931_s_at | 0.2187 | 0.4474 | |
| GSE97050 | SEH1L | 81929 | A_33_P3409934 | 0.4682 | 0.5720 | |
| SRP007169 | SEH1L | 81929 | RNAseq | 0.5014 | 0.1693 | |
| SRP008496 | SEH1L | 81929 | RNAseq | 0.3428 | 0.1141 | |
| SRP064894 | SEH1L | 81929 | RNAseq | 0.2436 | 0.2493 | |
| SRP133303 | SEH1L | 81929 | RNAseq | 0.4381 | 0.0463 | |
| SRP159526 | SEH1L | 81929 | RNAseq | 0.4281 | 0.1041 | |
| SRP193095 | SEH1L | 81929 | RNAseq | 0.2231 | 0.0751 | |
| SRP219564 | SEH1L | 81929 | RNAseq | -0.1546 | 0.5948 | |
| TCGA | SEH1L | 81929 | RNAseq | 0.1285 | 0.0165 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SEH1L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEH1L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEH1L | 81929 | 5 | 3 | 22 | |
| GSE20123 | SEH1L | 81929 | 5 | 3 | 22 | |
| GSE43470 | SEH1L | 81929 | 0 | 6 | 37 | |
| GSE46452 | SEH1L | 81929 | 3 | 21 | 35 | |
| GSE47630 | SEH1L | 81929 | 7 | 17 | 16 | |
| GSE54993 | SEH1L | 81929 | 6 | 2 | 62 | |
| GSE54994 | SEH1L | 81929 | 8 | 8 | 37 | |
| GSE60625 | SEH1L | 81929 | 0 | 4 | 7 | |
| GSE74703 | SEH1L | 81929 | 0 | 4 | 32 | |
| GSE74704 | SEH1L | 81929 | 3 | 2 | 15 | |
| TCGA | SEH1L | 81929 | 29 | 23 | 44 |
Total number of gains: 66; Total number of losses: 93; Total Number of normals: 329.
Somatic mutations of SEH1L:
Generating mutation plots.
Highly correlated genes for SEH1L:
Showing top 20/134 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEH1L | WDR75 | 0.704513 | 3 | 0 | 3 |
| SEH1L | FANCM | 0.659034 | 3 | 0 | 3 |
| SEH1L | LYPD1 | 0.658927 | 3 | 0 | 3 |
| SEH1L | RNMT | 0.650887 | 11 | 0 | 8 |
| SEH1L | AFG3L2 | 0.648673 | 8 | 0 | 7 |
| SEH1L | PSMG2 | 0.640255 | 10 | 0 | 9 |
| SEH1L | MPPE1 | 0.610083 | 4 | 0 | 3 |
| SEH1L | TMEM87B | 0.604129 | 3 | 0 | 3 |
| SEH1L | FUT8 | 0.599919 | 3 | 0 | 3 |
| SEH1L | PSMA3 | 0.599814 | 6 | 0 | 4 |
| SEH1L | FAM210A | 0.589109 | 4 | 0 | 3 |
| SEH1L | CEP76 | 0.587575 | 10 | 0 | 6 |
| SEH1L | PTPN2 | 0.583708 | 11 | 0 | 7 |
| SEH1L | NOC3L | 0.583391 | 7 | 0 | 6 |
| SEH1L | USP14 | 0.582112 | 11 | 0 | 8 |
| SEH1L | NCAPD2 | 0.57918 | 5 | 0 | 4 |
| SEH1L | SPC25 | 0.576154 | 5 | 0 | 4 |
| SEH1L | CCNE2 | 0.573388 | 5 | 0 | 3 |
| SEH1L | SP3 | 0.573313 | 4 | 0 | 3 |
| SEH1L | ZNF367 | 0.572148 | 3 | 0 | 3 |
For details and further investigation, click here
