| Full name: metallophosphoesterase 1 | Alias Symbol: PGAP5 | ||
| Type: protein-coding gene | Cytoband: 18p11.21 | ||
| Entrez ID: 65258 | HGNC ID: HGNC:15988 | Ensembl Gene: ENSG00000154889 | OMIM ID: 611900 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MPPE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MPPE1 | 65258 | 213727_x_at | 0.1020 | 0.8271 | |
| GSE20347 | MPPE1 | 65258 | 209858_x_at | 0.1529 | 0.2765 | |
| GSE23400 | MPPE1 | 65258 | 209858_x_at | 0.1387 | 0.0071 | |
| GSE26886 | MPPE1 | 65258 | 209858_x_at | 0.0102 | 0.9513 | |
| GSE29001 | MPPE1 | 65258 | 209858_x_at | 0.0116 | 0.9717 | |
| GSE38129 | MPPE1 | 65258 | 209858_x_at | 0.1440 | 0.2752 | |
| GSE45670 | MPPE1 | 65258 | 209858_x_at | -0.0870 | 0.5792 | |
| GSE53622 | MPPE1 | 65258 | 9700 | -0.0708 | 0.4834 | |
| GSE53624 | MPPE1 | 65258 | 9700 | 0.0373 | 0.6340 | |
| GSE63941 | MPPE1 | 65258 | 209858_x_at | -0.9054 | 0.0862 | |
| GSE77861 | MPPE1 | 65258 | 213727_x_at | 0.0270 | 0.9214 | |
| GSE97050 | MPPE1 | 65258 | A_23_P27285 | 0.1699 | 0.5337 | |
| SRP007169 | MPPE1 | 65258 | RNAseq | -1.0187 | 0.0129 | |
| SRP008496 | MPPE1 | 65258 | RNAseq | -0.6615 | 0.0077 | |
| SRP064894 | MPPE1 | 65258 | RNAseq | -0.2457 | 0.0942 | |
| SRP133303 | MPPE1 | 65258 | RNAseq | 0.3659 | 0.2260 | |
| SRP159526 | MPPE1 | 65258 | RNAseq | 0.2809 | 0.4610 | |
| SRP193095 | MPPE1 | 65258 | RNAseq | -0.0869 | 0.4340 | |
| SRP219564 | MPPE1 | 65258 | RNAseq | -0.1993 | 0.3658 | |
| TCGA | MPPE1 | 65258 | RNAseq | -0.2002 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MPPE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MPPE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MPPE1 | 65258 | 5 | 3 | 22 | |
| GSE20123 | MPPE1 | 65258 | 5 | 3 | 22 | |
| GSE43470 | MPPE1 | 65258 | 1 | 6 | 36 | |
| GSE46452 | MPPE1 | 65258 | 3 | 21 | 35 | |
| GSE47630 | MPPE1 | 65258 | 7 | 17 | 16 | |
| GSE54993 | MPPE1 | 65258 | 6 | 2 | 62 | |
| GSE54994 | MPPE1 | 65258 | 8 | 8 | 37 | |
| GSE60625 | MPPE1 | 65258 | 0 | 4 | 7 | |
| GSE74703 | MPPE1 | 65258 | 1 | 4 | 31 | |
| GSE74704 | MPPE1 | 65258 | 3 | 2 | 15 | |
| TCGA | MPPE1 | 65258 | 29 | 23 | 44 |
Total number of gains: 68; Total number of losses: 93; Total Number of normals: 327.
Somatic mutations of MPPE1:
Generating mutation plots.
Highly correlated genes for MPPE1:
Showing top 20/49 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MPPE1 | USP40 | 0.64762 | 3 | 0 | 3 |
| MPPE1 | RALBP1 | 0.645752 | 5 | 0 | 4 |
| MPPE1 | ANKRD9 | 0.627268 | 3 | 0 | 3 |
| MPPE1 | ANAPC13 | 0.621997 | 3 | 0 | 3 |
| MPPE1 | FADD | 0.621158 | 3 | 0 | 3 |
| MPPE1 | PHIP | 0.620601 | 3 | 0 | 3 |
| MPPE1 | SEH1L | 0.610083 | 4 | 0 | 3 |
| MPPE1 | TINF2 | 0.609431 | 3 | 0 | 3 |
| MPPE1 | LINC00698 | 0.591915 | 3 | 0 | 3 |
| MPPE1 | KLHL36 | 0.58956 | 4 | 0 | 3 |
| MPPE1 | BAG5 | 0.588974 | 3 | 0 | 3 |
| MPPE1 | PSMG2 | 0.58335 | 8 | 0 | 5 |
| MPPE1 | KANK4 | 0.579655 | 4 | 0 | 3 |
| MPPE1 | DOLK | 0.578108 | 4 | 0 | 3 |
| MPPE1 | PTPN2 | 0.573729 | 7 | 0 | 6 |
| MPPE1 | TWSG1 | 0.573254 | 4 | 0 | 3 |
| MPPE1 | KDM2A | 0.572429 | 4 | 0 | 4 |
| MPPE1 | AFG3L2 | 0.572359 | 7 | 0 | 4 |
| MPPE1 | RHBDF1 | 0.572007 | 4 | 0 | 3 |
| MPPE1 | LDB1 | 0.5719 | 4 | 0 | 3 |
For details and further investigation, click here
