| Full name: SH3 and multiple ankyrin repeat domains 2 | Alias Symbol: CTTNBP1|ProSAP1|SHANK|SPANK-3 | ||
| Type: protein-coding gene | Cytoband: 11q13.3-q13.4 | ||
| Entrez ID: 22941 | HGNC ID: HGNC:14295 | Ensembl Gene: ENSG00000162105 | OMIM ID: 603290 |
| Drug and gene relationship at DGIdb | |||
Expression of SHANK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SHANK2 | 22941 | 213308_at | -0.1131 | 0.9553 | |
| GSE20347 | SHANK2 | 22941 | 213308_at | 1.2445 | 0.0122 | |
| GSE23400 | SHANK2 | 22941 | 213308_at | 0.3514 | 0.0097 | |
| GSE26886 | SHANK2 | 22941 | 213308_at | 1.1711 | 0.0225 | |
| GSE29001 | SHANK2 | 22941 | 213308_at | 1.2293 | 0.1068 | |
| GSE38129 | SHANK2 | 22941 | 213308_at | 0.8944 | 0.0281 | |
| GSE45670 | SHANK2 | 22941 | 213308_at | 0.0820 | 0.9078 | |
| GSE53622 | SHANK2 | 22941 | 23906 | 0.5630 | 0.0167 | |
| GSE53624 | SHANK2 | 22941 | 48769 | 0.2971 | 0.1936 | |
| GSE63941 | SHANK2 | 22941 | 213308_at | 0.3127 | 0.7835 | |
| GSE77861 | SHANK2 | 22941 | 213308_at | 1.7749 | 0.0657 | |
| GSE97050 | SHANK2 | 22941 | A_33_P3374010 | 0.1057 | 0.9157 | |
| SRP007169 | SHANK2 | 22941 | RNAseq | 1.7242 | 0.0260 | |
| SRP008496 | SHANK2 | 22941 | RNAseq | 2.2748 | 0.0003 | |
| SRP064894 | SHANK2 | 22941 | RNAseq | -0.0382 | 0.9365 | |
| SRP133303 | SHANK2 | 22941 | RNAseq | 2.3043 | 0.0000 | |
| SRP159526 | SHANK2 | 22941 | RNAseq | 4.7916 | 0.0000 | |
| SRP193095 | SHANK2 | 22941 | RNAseq | 1.6889 | 0.0000 | |
| SRP219564 | SHANK2 | 22941 | RNAseq | 0.5701 | 0.4592 | |
| TCGA | SHANK2 | 22941 | RNAseq | -0.1705 | 0.4422 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by SHANK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SHANK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SHANK2 | 22941 | 20 | 1 | 9 | |
| GSE20123 | SHANK2 | 22941 | 20 | 1 | 9 | |
| GSE43470 | SHANK2 | 22941 | 13 | 3 | 27 | |
| GSE46452 | SHANK2 | 22941 | 31 | 3 | 25 | |
| GSE47630 | SHANK2 | 22941 | 17 | 4 | 19 | |
| GSE54993 | SHANK2 | 22941 | 1 | 22 | 47 | |
| GSE54994 | SHANK2 | 22941 | 22 | 7 | 24 | |
| GSE60625 | SHANK2 | 22941 | 0 | 8 | 3 | |
| GSE74703 | SHANK2 | 22941 | 10 | 2 | 24 | |
| GSE74704 | SHANK2 | 22941 | 13 | 0 | 7 | |
| TCGA | SHANK2 | 22941 | 62 | 4 | 30 |
Total number of gains: 209; Total number of losses: 55; Total Number of normals: 224.
Somatic mutations of SHANK2:
Generating mutation plots.
Highly correlated genes for SHANK2:
Showing top 20/58 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SHANK2 | MB | 0.714438 | 3 | 0 | 3 |
| SHANK2 | LEMD1 | 0.651679 | 3 | 0 | 3 |
| SHANK2 | FAR2 | 0.628922 | 4 | 0 | 3 |
| SHANK2 | MRPL11 | 0.624837 | 4 | 0 | 3 |
| SHANK2 | PTPRR | 0.618938 | 4 | 0 | 4 |
| SHANK2 | ZFP37 | 0.614161 | 3 | 0 | 3 |
| SHANK2 | LNP1 | 0.601654 | 3 | 0 | 3 |
| SHANK2 | MLPH | 0.593288 | 4 | 0 | 3 |
| SHANK2 | MAPRE1 | 0.589018 | 3 | 0 | 3 |
| SHANK2 | GFRA3 | 0.588253 | 4 | 0 | 4 |
| SHANK2 | TCF7L2 | 0.583559 | 4 | 0 | 4 |
| SHANK2 | PKIG | 0.58304 | 3 | 0 | 3 |
| SHANK2 | EFHD1 | 0.574317 | 4 | 0 | 3 |
| SHANK2 | MAP9 | 0.572583 | 5 | 0 | 4 |
| SHANK2 | PTH2R | 0.570183 | 3 | 0 | 3 |
| SHANK2 | TSC22D1 | 0.563888 | 4 | 0 | 3 |
| SHANK2 | BAMBI | 0.563241 | 4 | 0 | 3 |
| SHANK2 | EN1 | 0.561298 | 7 | 0 | 5 |
| SHANK2 | TTI1 | 0.558318 | 4 | 0 | 4 |
| SHANK2 | KDELR3 | 0.557299 | 5 | 0 | 3 |
For details and further investigation, click here
