| Full name: uroporphyrinogen decarboxylase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p34.1 | ||
| Entrez ID: 7389 | HGNC ID: HGNC:12591 | Ensembl Gene: ENSG00000126088 | OMIM ID: 613521 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UROD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UROD | 7389 | 208970_s_at | 0.1185 | 0.8292 | |
| GSE20347 | UROD | 7389 | 208970_s_at | 0.1026 | 0.3522 | |
| GSE23400 | UROD | 7389 | 208970_s_at | 0.2297 | 0.0019 | |
| GSE26886 | UROD | 7389 | 208970_s_at | 0.5987 | 0.0041 | |
| GSE29001 | UROD | 7389 | 208970_s_at | 0.1960 | 0.2572 | |
| GSE38129 | UROD | 7389 | 208970_s_at | -0.0067 | 0.9528 | |
| GSE45670 | UROD | 7389 | 208970_s_at | -0.0174 | 0.9224 | |
| GSE53622 | UROD | 7389 | 130882 | 0.0297 | 0.6390 | |
| GSE53624 | UROD | 7389 | 130882 | 0.3089 | 0.0000 | |
| GSE63941 | UROD | 7389 | 208970_s_at | -0.3902 | 0.3762 | |
| GSE77861 | UROD | 7389 | 208970_s_at | 0.0546 | 0.8827 | |
| GSE97050 | UROD | 7389 | A_23_P63050 | 0.0158 | 0.9577 | |
| SRP007169 | UROD | 7389 | RNAseq | 0.5489 | 0.3666 | |
| SRP008496 | UROD | 7389 | RNAseq | 1.2000 | 0.0093 | |
| SRP064894 | UROD | 7389 | RNAseq | 0.7326 | 0.0082 | |
| SRP133303 | UROD | 7389 | RNAseq | 0.0603 | 0.7313 | |
| SRP159526 | UROD | 7389 | RNAseq | 0.3003 | 0.3443 | |
| SRP193095 | UROD | 7389 | RNAseq | 0.0909 | 0.4786 | |
| SRP219564 | UROD | 7389 | RNAseq | 0.3026 | 0.5169 | |
| TCGA | UROD | 7389 | RNAseq | -0.0212 | 0.6896 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by UROD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UROD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UROD | 7389 | 4 | 3 | 23 | |
| GSE20123 | UROD | 7389 | 4 | 2 | 24 | |
| GSE43470 | UROD | 7389 | 7 | 2 | 34 | |
| GSE46452 | UROD | 7389 | 2 | 1 | 56 | |
| GSE47630 | UROD | 7389 | 9 | 3 | 28 | |
| GSE54993 | UROD | 7389 | 0 | 1 | 69 | |
| GSE54994 | UROD | 7389 | 13 | 2 | 38 | |
| GSE60625 | UROD | 7389 | 0 | 0 | 11 | |
| GSE74703 | UROD | 7389 | 6 | 1 | 29 | |
| GSE74704 | UROD | 7389 | 2 | 0 | 18 | |
| TCGA | UROD | 7389 | 12 | 16 | 68 |
Total number of gains: 59; Total number of losses: 31; Total Number of normals: 398.
Somatic mutations of UROD:
Generating mutation plots.
Highly correlated genes for UROD:
Showing top 20/96 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UROD | MOK | 0.718817 | 3 | 0 | 3 |
| UROD | SIX2 | 0.659611 | 3 | 0 | 3 |
| UROD | PAQR3 | 0.65334 | 3 | 0 | 3 |
| UROD | WFDC3 | 0.639623 | 3 | 0 | 3 |
| UROD | TRDMT1 | 0.597161 | 3 | 0 | 3 |
| UROD | EFCAB7 | 0.594838 | 5 | 0 | 3 |
| UROD | PIK3R4 | 0.590042 | 3 | 0 | 3 |
| UROD | ZNF580 | 0.583807 | 4 | 0 | 3 |
| UROD | EXTL3 | 0.583623 | 4 | 0 | 3 |
| UROD | NCOR2 | 0.580331 | 3 | 0 | 3 |
| UROD | IFT43 | 0.580109 | 6 | 0 | 5 |
| UROD | MAP7D3 | 0.575228 | 5 | 0 | 3 |
| UROD | SDCCAG8 | 0.574152 | 4 | 0 | 3 |
| UROD | NACAD | 0.572557 | 5 | 0 | 4 |
| UROD | MRPL11 | 0.570743 | 4 | 0 | 3 |
| UROD | LENG1 | 0.567306 | 4 | 0 | 3 |
| UROD | GPAM | 0.561708 | 4 | 0 | 3 |
| UROD | BST1 | 0.560517 | 6 | 0 | 3 |
| UROD | CDK17 | 0.560397 | 5 | 0 | 3 |
| UROD | ITGB3BP | 0.559695 | 6 | 0 | 4 |
For details and further investigation, click here
