| Full name: serine peptidase inhibitor, Kazal type 6 | Alias Symbol: MGC21394|UNQ844|BUSI2 | ||
| Type: protein-coding gene | Cytoband: 5q32 | ||
| Entrez ID: 404203 | HGNC ID: HGNC:29486 | Ensembl Gene: ENSG00000178172 | OMIM ID: 615868 |
| Drug and gene relationship at DGIdb | |||
Expression of SPINK6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPINK6 | 404203 | 1553973_a_at | 0.7113 | 0.6900 | |
| GSE26886 | SPINK6 | 404203 | 1553973_a_at | -0.2379 | 0.7305 | |
| GSE45670 | SPINK6 | 404203 | 1553973_a_at | -0.4705 | 0.6876 | |
| GSE53622 | SPINK6 | 404203 | 71385 | 0.2965 | 0.5687 | |
| GSE53624 | SPINK6 | 404203 | 71385 | -0.3333 | 0.4313 | |
| GSE63941 | SPINK6 | 404203 | 1553973_a_at | 0.3062 | 0.5403 | |
| GSE77861 | SPINK6 | 404203 | 1553973_a_at | -0.9863 | 0.2485 | |
| GSE97050 | SPINK6 | 404203 | A_23_P92909 | 0.1528 | 0.7009 | |
| SRP133303 | SPINK6 | 404203 | RNAseq | 1.8844 | 0.0449 | |
| TCGA | SPINK6 | 404203 | RNAseq | 0.6646 | 0.4934 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SPINK6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPINK6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPINK6 | 404203 | 1 | 12 | 17 | |
| GSE20123 | SPINK6 | 404203 | 1 | 13 | 16 | |
| GSE43470 | SPINK6 | 404203 | 2 | 9 | 32 | |
| GSE46452 | SPINK6 | 404203 | 0 | 27 | 32 | |
| GSE47630 | SPINK6 | 404203 | 0 | 20 | 20 | |
| GSE54993 | SPINK6 | 404203 | 9 | 1 | 60 | |
| GSE54994 | SPINK6 | 404203 | 2 | 15 | 36 | |
| GSE60625 | SPINK6 | 404203 | 0 | 0 | 11 | |
| GSE74703 | SPINK6 | 404203 | 2 | 7 | 27 | |
| GSE74704 | SPINK6 | 404203 | 1 | 8 | 11 | |
| TCGA | SPINK6 | 404203 | 5 | 38 | 53 |
Total number of gains: 23; Total number of losses: 150; Total Number of normals: 315.
Somatic mutations of SPINK6:
Generating mutation plots.
Highly correlated genes for SPINK6:
Showing top 20/22 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPINK6 | KANK4 | 0.703776 | 3 | 0 | 3 |
| SPINK6 | C5AR2 | 0.696132 | 3 | 0 | 3 |
| SPINK6 | C3orf80 | 0.632735 | 3 | 0 | 3 |
| SPINK6 | DEPDC4 | 0.615697 | 4 | 0 | 3 |
| SPINK6 | TIMM23 | 0.61326 | 3 | 0 | 3 |
| SPINK6 | NOXO1 | 0.612473 | 4 | 0 | 4 |
| SPINK6 | SPAG1 | 0.609273 | 3 | 0 | 3 |
| SPINK6 | SLC32A1 | 0.591562 | 3 | 0 | 3 |
| SPINK6 | CD55 | 0.578191 | 3 | 0 | 3 |
| SPINK6 | WDR89 | 0.566639 | 3 | 0 | 3 |
| SPINK6 | PCSK1 | 0.563528 | 3 | 0 | 3 |
| SPINK6 | SCN8A | 0.555105 | 4 | 0 | 3 |
| SPINK6 | IPMK | 0.550077 | 3 | 0 | 3 |
| SPINK6 | SLC6A2 | 0.548261 | 4 | 0 | 3 |
| SPINK6 | KLHL18 | 0.548102 | 4 | 0 | 3 |
| SPINK6 | ZFP36L1 | 0.547005 | 3 | 0 | 3 |
| SPINK6 | STRN | 0.542949 | 3 | 0 | 3 |
| SPINK6 | CYP4F22 | 0.529826 | 3 | 0 | 3 |
| SPINK6 | PNLIPRP3 | 0.518446 | 7 | 0 | 3 |
| SPINK6 | WNT11 | 0.514547 | 5 | 0 | 3 |
For details and further investigation, click here
