| Full name: syntaxin 5 | Alias Symbol: SED5 | ||
| Type: protein-coding gene | Cytoband: 11q12.3 | ||
| Entrez ID: 6811 | HGNC ID: HGNC:11440 | Ensembl Gene: ENSG00000162236 | OMIM ID: 603189 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of STX5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STX5 | 6811 | 203330_s_at | 0.1263 | 0.6550 | |
| GSE20347 | STX5 | 6811 | 203330_s_at | -0.2882 | 0.0093 | |
| GSE23400 | STX5 | 6811 | 203330_s_at | -0.0525 | 0.2564 | |
| GSE26886 | STX5 | 6811 | 203330_s_at | -0.4110 | 0.0161 | |
| GSE29001 | STX5 | 6811 | 203330_s_at | -0.3451 | 0.0613 | |
| GSE38129 | STX5 | 6811 | 203330_s_at | -0.2034 | 0.0323 | |
| GSE45670 | STX5 | 6811 | 203330_s_at | 0.0013 | 0.9925 | |
| GSE53622 | STX5 | 6811 | 122694 | -0.2019 | 0.0033 | |
| GSE53624 | STX5 | 6811 | 122694 | -0.0602 | 0.2426 | |
| GSE63941 | STX5 | 6811 | 203330_s_at | 1.9542 | 0.0002 | |
| GSE77861 | STX5 | 6811 | 203330_s_at | 0.0125 | 0.9542 | |
| GSE97050 | STX5 | 6811 | A_23_P24755 | 0.0839 | 0.7191 | |
| SRP007169 | STX5 | 6811 | RNAseq | -1.0599 | 0.0036 | |
| SRP008496 | STX5 | 6811 | RNAseq | -0.9520 | 0.0000 | |
| SRP064894 | STX5 | 6811 | RNAseq | -0.1093 | 0.6731 | |
| SRP133303 | STX5 | 6811 | RNAseq | -0.1190 | 0.4932 | |
| SRP159526 | STX5 | 6811 | RNAseq | -0.4186 | 0.0312 | |
| SRP193095 | STX5 | 6811 | RNAseq | -0.2687 | 0.0163 | |
| SRP219564 | STX5 | 6811 | RNAseq | -0.2358 | 0.5012 | |
| TCGA | STX5 | 6811 | RNAseq | -0.0630 | 0.1992 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by STX5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STX5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STX5 | 6811 | 6 | 5 | 19 | |
| GSE20123 | STX5 | 6811 | 6 | 5 | 19 | |
| GSE43470 | STX5 | 6811 | 1 | 6 | 36 | |
| GSE46452 | STX5 | 6811 | 8 | 4 | 47 | |
| GSE47630 | STX5 | 6811 | 3 | 7 | 30 | |
| GSE54993 | STX5 | 6811 | 3 | 0 | 67 | |
| GSE54994 | STX5 | 6811 | 5 | 5 | 43 | |
| GSE60625 | STX5 | 6811 | 0 | 3 | 8 | |
| GSE74703 | STX5 | 6811 | 1 | 3 | 32 | |
| GSE74704 | STX5 | 6811 | 4 | 3 | 13 | |
| TCGA | STX5 | 6811 | 12 | 11 | 73 |
Total number of gains: 49; Total number of losses: 52; Total Number of normals: 387.
Somatic mutations of STX5:
Generating mutation plots.
Highly correlated genes for STX5:
Showing top 20/280 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STX5 | TBCD | 0.743125 | 4 | 0 | 3 |
| STX5 | SLC1A5 | 0.729724 | 3 | 0 | 3 |
| STX5 | TRAPPC5 | 0.709434 | 3 | 0 | 3 |
| STX5 | BTBD2 | 0.699875 | 4 | 0 | 4 |
| STX5 | ACIN1 | 0.697915 | 3 | 0 | 3 |
| STX5 | ASPSCR1 | 0.688967 | 3 | 0 | 3 |
| STX5 | PTPN6 | 0.688787 | 3 | 0 | 3 |
| STX5 | ATG7 | 0.68665 | 3 | 0 | 3 |
| STX5 | RAB4B | 0.683354 | 3 | 0 | 3 |
| STX5 | ALG3 | 0.682182 | 4 | 0 | 3 |
| STX5 | DPM2 | 0.681487 | 3 | 0 | 3 |
| STX5 | ARMC6 | 0.67575 | 3 | 0 | 3 |
| STX5 | FIZ1 | 0.675509 | 4 | 0 | 4 |
| STX5 | FKBP4 | 0.670731 | 3 | 0 | 3 |
| STX5 | CDK4 | 0.670714 | 3 | 0 | 3 |
| STX5 | EXD2 | 0.670162 | 3 | 0 | 3 |
| STX5 | FBXL19 | 0.669205 | 4 | 0 | 3 |
| STX5 | MXD3 | 0.667594 | 3 | 0 | 3 |
| STX5 | PNO1 | 0.66557 | 3 | 0 | 3 |
| STX5 | MEN1 | 0.663995 | 3 | 0 | 3 |
For details and further investigation, click here
