YBX1

 

Full name: Y-box binding protein 1 Alias Symbol: YB-1|YB1|DBPB|NSEP-1|MDR-NF1|BP-8|CSDB|CSDA2
Type: protein-coding gene Cytoband: 1p34.2
Entrez ID: 4904 HGNC ID: HGNC:8014 Ensembl Gene: ENSG00000065978 OMIM ID: 154030
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of YBX1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 YBX1 4904 208628_s_at 0.4818 0.1292
GSE20347 YBX1 4904 208628_s_at 0.6721 0.0000
GSE23400 YBX1 4904 208628_s_at 0.6602 0.0000
GSE26886 YBX1 4904 208628_s_at 0.2460 0.2498
GSE29001 YBX1 4904 208628_s_at 0.4915 0.0912
GSE38129 YBX1 4904 208628_s_at 0.5108 0.0000
GSE45670 YBX1 4904 208628_s_at 0.2623 0.0607
GSE63941 YBX1 4904 208628_s_at 0.1563 0.7335
GSE77861 YBX1 4904 208628_s_at 0.3093 0.3473
GSE97050 YBX1 4904 A_24_P101391 0.1155 0.7169
SRP007169 YBX1 4904 RNAseq 1.3071 0.0009
SRP008496 YBX1 4904 RNAseq 1.3073 0.0000
SRP064894 YBX1 4904 RNAseq 0.3790 0.0737
SRP133303 YBX1 4904 RNAseq 0.5575 0.0071
SRP193095 YBX1 4904 RNAseq 0.3756 0.0259
SRP219564 YBX1 4904 RNAseq 0.3880 0.3871
TCGA YBX1 4904 RNAseq 0.0640 0.1007

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by YBX1 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of YBX1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 YBX1 4904 4 3 23
GSE20123 YBX1 4904 3 2 25
GSE43470 YBX1 4904 7 2 34
GSE46452 YBX1 4904 3 1 55
GSE47630 YBX1 4904 9 2 29
GSE54993 YBX1 4904 0 2 68
GSE54994 YBX1 4904 14 2 37
GSE60625 YBX1 4904 0 0 11
GSE74703 YBX1 4904 6 1 29
GSE74704 YBX1 4904 1 0 19
TCGA YBX1 4904 13 16 67

Total number of gains: 60; Total number of losses: 31; Total Number of normals: 397.  

 

Somatic mutations of YBX1:

 

Generating mutation plots.

 

Highly correlated genes for YBX1:

 

Showing top 20/933 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
YBX1SIX40.745984303
YBX1NASP0.742754908
YBX1ERI30.72657706
YBX1TUBB0.725188907
YBX1JOSD10.723431505
YBX1KDM1A0.722435707
YBX1PRMT10.721667707
YBX1SUPT16H0.714759606
YBX1TXNDC120.71305404
YBX1HNRNPC0.711976808
YBX1MCM30.706756707
YBX1SNRPA0.699209606
YBX1NUP1070.698934707
YBX1CCNB10.694188505
YBX1SMYD30.693155505
YBX1NR2C2AP0.691819303
YBX1NRM0.689619303
YBX1RUVBL10.68707907
YBX1PLA2G150.686768505
YBX1MCM70.685972807

For details and further investigation, click here