| Full name: trafficking from ER to golgi regulator | Alias Symbol: TF6|FLJ36137|SPG57 | ||
| Type: protein-coding gene | Cytoband: 3q12.2 | ||
| Entrez ID: 10342 | HGNC ID: HGNC:11758 | Ensembl Gene: ENSG00000114354 | OMIM ID: 602498 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
TFG involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05200 | Pathways in cancer | |
| hsa05216 | Thyroid cancer |
Expression of TFG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TFG | 10342 | 217839_at | 0.1848 | 0.5987 | |
| GSE20347 | TFG | 10342 | 217839_at | 0.1697 | 0.1867 | |
| GSE23400 | TFG | 10342 | 217839_at | 0.3173 | 0.0000 | |
| GSE26886 | TFG | 10342 | 217839_at | 0.0224 | 0.8968 | |
| GSE29001 | TFG | 10342 | 217839_at | -0.0799 | 0.7158 | |
| GSE38129 | TFG | 10342 | 217839_at | 0.3164 | 0.0398 | |
| GSE45670 | TFG | 10342 | 217839_at | 0.4449 | 0.0027 | |
| GSE53622 | TFG | 10342 | 15463 | 0.5233 | 0.0000 | |
| GSE53624 | TFG | 10342 | 15463 | 0.5306 | 0.0000 | |
| GSE63941 | TFG | 10342 | 217839_at | 0.9934 | 0.0091 | |
| GSE77861 | TFG | 10342 | 217839_at | 0.1195 | 0.7443 | |
| GSE97050 | TFG | 10342 | A_24_P345822 | 0.9705 | 0.0555 | |
| SRP007169 | TFG | 10342 | RNAseq | -0.4837 | 0.2532 | |
| SRP008496 | TFG | 10342 | RNAseq | -0.5593 | 0.0175 | |
| SRP064894 | TFG | 10342 | RNAseq | 0.2711 | 0.1434 | |
| SRP133303 | TFG | 10342 | RNAseq | 0.2998 | 0.1055 | |
| SRP159526 | TFG | 10342 | RNAseq | 0.1777 | 0.5178 | |
| SRP193095 | TFG | 10342 | RNAseq | 0.1754 | 0.2374 | |
| SRP219564 | TFG | 10342 | RNAseq | 0.1584 | 0.5950 | |
| TCGA | TFG | 10342 | RNAseq | 0.1931 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TFG expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TFG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TFG | 10342 | 17 | 1 | 12 | |
| GSE20123 | TFG | 10342 | 16 | 1 | 13 | |
| GSE43470 | TFG | 10342 | 19 | 1 | 23 | |
| GSE46452 | TFG | 10342 | 12 | 6 | 41 | |
| GSE47630 | TFG | 10342 | 16 | 6 | 18 | |
| GSE54993 | TFG | 10342 | 2 | 5 | 63 | |
| GSE54994 | TFG | 10342 | 27 | 5 | 21 | |
| GSE60625 | TFG | 10342 | 0 | 6 | 5 | |
| GSE74703 | TFG | 10342 | 15 | 1 | 20 | |
| GSE74704 | TFG | 10342 | 13 | 1 | 6 | |
| TCGA | TFG | 10342 | 48 | 9 | 39 |
Total number of gains: 185; Total number of losses: 42; Total Number of normals: 261.
Somatic mutations of TFG:
Generating mutation plots.
Highly correlated genes for TFG:
Showing top 20/617 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TFG | COX16 | 0.69345 | 3 | 0 | 3 |
| TFG | LRP8 | 0.655768 | 5 | 0 | 5 |
| TFG | ADAMTS14 | 0.653326 | 3 | 0 | 3 |
| TFG | NIT2 | 0.650147 | 10 | 0 | 9 |
| TFG | EBNA1BP2 | 0.648916 | 3 | 0 | 3 |
| TFG | MRPS12 | 0.64821 | 4 | 0 | 4 |
| TFG | RPN1 | 0.644765 | 8 | 0 | 7 |
| TFG | SLC39A8 | 0.640374 | 3 | 0 | 3 |
| TFG | FAM91A1 | 0.639966 | 5 | 0 | 5 |
| TFG | CAPN1 | 0.638426 | 3 | 0 | 3 |
| TFG | TRMT10C | 0.637685 | 7 | 0 | 6 |
| TFG | MICALCL | 0.636661 | 3 | 0 | 3 |
| TFG | EIF4G1 | 0.636486 | 9 | 0 | 9 |
| TFG | KLHL6 | 0.633724 | 3 | 0 | 3 |
| TFG | LILRB1 | 0.632797 | 3 | 0 | 3 |
| TFG | COPG1 | 0.632657 | 8 | 0 | 6 |
| TFG | C11orf80 | 0.628607 | 4 | 0 | 3 |
| TFG | STRN4 | 0.628075 | 3 | 0 | 3 |
| TFG | DNAJB11 | 0.625714 | 6 | 0 | 5 |
| TFG | RASA2 | 0.625027 | 5 | 0 | 4 |
For details and further investigation, click here
