| Full name: transmembrane O-mannosyltransferase targeting cadherins 2 | Alias Symbol: DKFZp762A217 | ||
| Type: protein-coding gene | Cytoband: 12q21.31 | ||
| Entrez ID: 160335 | HGNC ID: HGNC:25440 | Ensembl Gene: ENSG00000179104 | OMIM ID: 615856 |
| Drug and gene relationship at DGIdb | |||
Expression of TMTC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMTC2 | 160335 | 235775_at | -0.6628 | 0.4361 | |
| GSE26886 | TMTC2 | 160335 | 228574_at | -0.0184 | 0.9574 | |
| GSE45670 | TMTC2 | 160335 | 228574_at | -0.2223 | 0.4143 | |
| GSE53622 | TMTC2 | 160335 | 44346 | -0.9386 | 0.0000 | |
| GSE53624 | TMTC2 | 160335 | 44346 | -1.0217 | 0.0000 | |
| GSE63941 | TMTC2 | 160335 | 235775_at | -0.5097 | 0.5359 | |
| GSE77861 | TMTC2 | 160335 | 228574_at | -0.2138 | 0.4310 | |
| GSE97050 | TMTC2 | 160335 | A_23_P382705 | 0.3099 | 0.4077 | |
| SRP007169 | TMTC2 | 160335 | RNAseq | -0.4381 | 0.3293 | |
| SRP008496 | TMTC2 | 160335 | RNAseq | -0.6727 | 0.0265 | |
| SRP064894 | TMTC2 | 160335 | RNAseq | -1.2826 | 0.0000 | |
| SRP133303 | TMTC2 | 160335 | RNAseq | -0.6096 | 0.0151 | |
| SRP159526 | TMTC2 | 160335 | RNAseq | -0.7201 | 0.0674 | |
| SRP193095 | TMTC2 | 160335 | RNAseq | -1.0053 | 0.0000 | |
| SRP219564 | TMTC2 | 160335 | RNAseq | -0.8122 | 0.2745 | |
| TCGA | TMTC2 | 160335 | RNAseq | -0.4264 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by TMTC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMTC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMTC2 | 160335 | 2 | 4 | 24 | |
| GSE20123 | TMTC2 | 160335 | 2 | 4 | 24 | |
| GSE43470 | TMTC2 | 160335 | 3 | 1 | 39 | |
| GSE46452 | TMTC2 | 160335 | 9 | 1 | 49 | |
| GSE47630 | TMTC2 | 160335 | 10 | 1 | 29 | |
| GSE54993 | TMTC2 | 160335 | 0 | 5 | 65 | |
| GSE54994 | TMTC2 | 160335 | 7 | 1 | 45 | |
| GSE60625 | TMTC2 | 160335 | 0 | 0 | 11 | |
| GSE74703 | TMTC2 | 160335 | 3 | 1 | 32 | |
| GSE74704 | TMTC2 | 160335 | 1 | 3 | 16 | |
| TCGA | TMTC2 | 160335 | 19 | 10 | 67 |
Total number of gains: 56; Total number of losses: 31; Total Number of normals: 401.
Somatic mutations of TMTC2:
Generating mutation plots.
Highly correlated genes for TMTC2:
Showing top 20/310 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMTC2 | FAM3B | 0.686834 | 4 | 0 | 4 |
| TMTC2 | MECOM | 0.685967 | 4 | 0 | 4 |
| TMTC2 | HPGD | 0.681993 | 4 | 0 | 4 |
| TMTC2 | METTL25 | 0.665748 | 4 | 0 | 4 |
| TMTC2 | SLC9A3R1 | 0.661951 | 4 | 0 | 3 |
| TMTC2 | TRIM29 | 0.658622 | 3 | 0 | 3 |
| TMTC2 | ERBB3 | 0.656118 | 5 | 0 | 5 |
| TMTC2 | VPS4B | 0.651624 | 4 | 0 | 4 |
| TMTC2 | CCNG2 | 0.648083 | 4 | 0 | 4 |
| TMTC2 | SOX21-AS1 | 0.644492 | 3 | 0 | 3 |
| TMTC2 | GNPTAB | 0.641684 | 3 | 0 | 3 |
| TMTC2 | TPRG1L | 0.638009 | 3 | 0 | 3 |
| TMTC2 | SCP2 | 0.635846 | 4 | 0 | 4 |
| TMTC2 | MUC20 | 0.633161 | 4 | 0 | 3 |
| TMTC2 | CCDC186 | 0.630124 | 4 | 0 | 3 |
| TMTC2 | MPP7 | 0.628161 | 4 | 0 | 4 |
| TMTC2 | VSIG2 | 0.62551 | 4 | 0 | 4 |
| TMTC2 | AKR1A1 | 0.62426 | 5 | 0 | 3 |
| TMTC2 | FUT3 | 0.624098 | 6 | 0 | 5 |
| TMTC2 | RPS6KA3 | 0.622319 | 4 | 0 | 3 |
For details and further investigation, click here
