| Full name: TNF receptor superfamily member 11a | Alias Symbol: RANK|CD265|FEO | ||
| Type: protein-coding gene | Cytoband: 18q21.33 | ||
| Entrez ID: 8792 | HGNC ID: HGNC:11908 | Ensembl Gene: ENSG00000141655 | OMIM ID: 603499 |
| Related drugs: CHEMBL300914... [more] | |||
TNFRSF11A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04064 | NF-kappa B signaling pathway | |
| hsa04380 | Osteoclast differentiation | |
| hsa04917 | Prolactin signaling pathway |
Expression of TNFRSF11A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNFRSF11A | 8792 | 238846_at | -0.9187 | 0.4581 | |
| GSE20347 | TNFRSF11A | 8792 | 207037_at | -0.2804 | 0.0032 | |
| GSE23400 | TNFRSF11A | 8792 | 207037_at | -0.1998 | 0.0000 | |
| GSE26886 | TNFRSF11A | 8792 | 238846_at | -1.6593 | 0.0001 | |
| GSE29001 | TNFRSF11A | 8792 | 207037_at | -0.6430 | 0.0315 | |
| GSE38129 | TNFRSF11A | 8792 | 207037_at | -0.2816 | 0.0016 | |
| GSE45670 | TNFRSF11A | 8792 | 238846_at | -0.7825 | 0.0194 | |
| GSE53622 | TNFRSF11A | 8792 | 87923 | -1.0841 | 0.0000 | |
| GSE53624 | TNFRSF11A | 8792 | 87923 | -1.1660 | 0.0000 | |
| GSE63941 | TNFRSF11A | 8792 | 207037_at | 0.4993 | 0.0868 | |
| GSE77861 | TNFRSF11A | 8792 | 207037_at | -0.0966 | 0.3816 | |
| SRP007169 | TNFRSF11A | 8792 | RNAseq | -2.5784 | 0.0000 | |
| SRP064894 | TNFRSF11A | 8792 | RNAseq | -1.0629 | 0.0000 | |
| SRP133303 | TNFRSF11A | 8792 | RNAseq | -0.9100 | 0.0001 | |
| SRP159526 | TNFRSF11A | 8792 | RNAseq | -0.4883 | 0.2483 | |
| SRP193095 | TNFRSF11A | 8792 | RNAseq | -1.0255 | 0.0062 | |
| SRP219564 | TNFRSF11A | 8792 | RNAseq | -0.7384 | 0.0760 | |
| TCGA | TNFRSF11A | 8792 | RNAseq | -0.1929 | 0.2728 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by TNFRSF11A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNFRSF11A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNFRSF11A | 8792 | 1 | 9 | 20 | |
| GSE20123 | TNFRSF11A | 8792 | 1 | 9 | 20 | |
| GSE43470 | TNFRSF11A | 8792 | 0 | 5 | 38 | |
| GSE46452 | TNFRSF11A | 8792 | 1 | 26 | 32 | |
| GSE47630 | TNFRSF11A | 8792 | 5 | 21 | 14 | |
| GSE54993 | TNFRSF11A | 8792 | 9 | 0 | 61 | |
| GSE54994 | TNFRSF11A | 8792 | 1 | 18 | 34 | |
| GSE60625 | TNFRSF11A | 8792 | 0 | 4 | 7 | |
| GSE74703 | TNFRSF11A | 8792 | 0 | 5 | 31 | |
| GSE74704 | TNFRSF11A | 8792 | 1 | 6 | 13 | |
| TCGA | TNFRSF11A | 8792 | 11 | 45 | 40 |
Total number of gains: 30; Total number of losses: 148; Total Number of normals: 310.
Somatic mutations of TNFRSF11A:
Generating mutation plots.
Highly correlated genes for TNFRSF11A:
Showing top 20/593 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNFRSF11A | AP4B1 | 0.68513 | 4 | 0 | 4 |
| TNFRSF11A | SPNS3 | 0.654073 | 3 | 0 | 3 |
| TNFRSF11A | TIFA | 0.650396 | 6 | 0 | 5 |
| TNFRSF11A | PCBP1-AS1 | 0.649753 | 3 | 0 | 3 |
| TNFRSF11A | CYP2J2 | 0.641203 | 10 | 0 | 10 |
| TNFRSF11A | TPRN | 0.639282 | 4 | 0 | 3 |
| TNFRSF11A | SH2D1B | 0.638523 | 3 | 0 | 3 |
| TNFRSF11A | ABHD12 | 0.634757 | 5 | 0 | 4 |
| TNFRSF11A | CAMSAP3 | 0.63374 | 5 | 0 | 4 |
| TNFRSF11A | PLEKHA7 | 0.633059 | 7 | 0 | 6 |
| TNFRSF11A | SLC44A3 | 0.632172 | 6 | 0 | 5 |
| TNFRSF11A | IL34 | 0.629696 | 3 | 0 | 3 |
| TNFRSF11A | CXCL17 | 0.629158 | 7 | 0 | 6 |
| TNFRSF11A | CGN | 0.623671 | 7 | 0 | 5 |
| TNFRSF11A | LNX1 | 0.622173 | 6 | 0 | 6 |
| TNFRSF11A | FCER1A | 0.621378 | 10 | 0 | 10 |
| TNFRSF11A | PKIB | 0.615486 | 5 | 0 | 5 |
| TNFRSF11A | PHLDB3 | 0.613197 | 4 | 0 | 3 |
| TNFRSF11A | CCDC12 | 0.612539 | 4 | 0 | 3 |
| TNFRSF11A | DEGS2 | 0.61224 | 6 | 0 | 5 |
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