POLE

 

Full name: DNA polymerase epsilon, catalytic subunit Alias Symbol: POLE1
Type: protein-coding gene Cytoband: 12q24.33
Entrez ID: 5426 HGNC ID: HGNC:9177 Ensembl Gene: ENSG00000177084 OMIM ID: 174762
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

POLE involved pathways:

KEGG pathway Description View
hsa05166HTLV-I infection

 

Expression of POLE:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 POLE 5426 216026_s_at 0.8373 0.0420
GSE20347 POLE 5426 216026_s_at 0.2996 0.0079
GSE23400 POLE 5426 216026_s_at 0.2674 0.0000
GSE26886 POLE 5426 216026_s_at 0.6308 0.0004
GSE29001 POLE 5426 216026_s_at 0.4572 0.0091
GSE38129 POLE 5426 216026_s_at 0.3654 0.0004
GSE45670 POLE 5426 216026_s_at 0.3486 0.0096
GSE53622 POLE 5426 69238 1.0198 0.0000
GSE53624 POLE 5426 6953 0.7493 0.0000
GSE63941 POLE 5426 216026_s_at 0.7487 0.0211
GSE77861 POLE 5426 216026_s_at 0.2657 0.1232
GSE97050 POLE 5426 A_33_P3695548 0.9602 0.1095
SRP007169 POLE 5426 RNAseq 3.1438 0.0000
SRP008496 POLE 5426 RNAseq 2.4343 0.0000
SRP064894 POLE 5426 RNAseq 0.6679 0.0037
SRP133303 POLE 5426 RNAseq 0.4498 0.0174
SRP159526 POLE 5426 RNAseq 1.2024 0.0274
SRP193095 POLE 5426 RNAseq 0.7381 0.0000
SRP219564 POLE 5426 RNAseq 0.4727 0.2050
TCGA POLE 5426 RNAseq 0.1413 0.0059

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by POLE expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of POLE:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 POLE 5426 4 5 21
GSE20123 POLE 5426 4 5 21
GSE43470 POLE 5426 3 3 37
GSE46452 POLE 5426 8 3 48
GSE47630 POLE 5426 9 3 28
GSE54993 POLE 5426 0 6 64
GSE54994 POLE 5426 4 8 41
GSE60625 POLE 5426 1 0 10
GSE74703 POLE 5426 2 3 31
GSE74704 POLE 5426 2 3 15
TCGA POLE 5426 21 15 60

Total number of gains: 58; Total number of losses: 54; Total Number of normals: 376.  

 

Somatic mutations of POLE:

 

Generating mutation plots.

 

Highly correlated genes for POLE:

 

Showing top 20/909 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
POLEC19orf480.722934403
POLETONSL0.718544605
POLEKNTC10.70565711011
POLETROAP0.69988311011
POLEUBE2T0.690472707
POLEZNF5980.689913505
POLENKX2-20.687402303
POLELRWD10.686718303
POLEZGRF10.684721504
POLENR2E10.684483303
POLEMCM20.67733712011
POLESTIL0.67645311010
POLEESCO20.675911606
POLEDNMT10.67347611011
POLEMTBP0.672094505
POLECDCA20.669663505
POLETICRR0.669643606
POLEKIF18B0.6691811010
POLETRIP130.66506612011
POLEFBRSL10.66239504

For details and further investigation, click here