| Full name: tyrosinase | Alias Symbol: OCAIA|OCA1A|OCA1 | ||
| Type: protein-coding gene | Cytoband: 11q14.3 | ||
| Entrez ID: 7299 | HGNC ID: HGNC:12442 | Ensembl Gene: ENSG00000077498 | OMIM ID: 606933 |
| Drug and gene relationship at DGIdb | |||
TYR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04916 | Melanogenesis |
Expression of TYR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TYR | 7299 | 206630_at | -0.2025 | 0.3318 | |
| GSE20347 | TYR | 7299 | 206630_at | -0.1532 | 0.1081 | |
| GSE23400 | TYR | 7299 | 206630_at | -0.2632 | 0.0000 | |
| GSE26886 | TYR | 7299 | 206630_at | -0.6279 | 0.0001 | |
| GSE29001 | TYR | 7299 | 206630_at | -0.4361 | 0.0457 | |
| GSE38129 | TYR | 7299 | 206630_at | -0.2487 | 0.0012 | |
| GSE45670 | TYR | 7299 | 206630_at | -0.2166 | 0.0741 | |
| GSE53622 | TYR | 7299 | 8223 | -0.1121 | 0.2170 | |
| GSE53624 | TYR | 7299 | 8223 | -0.2519 | 0.0528 | |
| GSE63941 | TYR | 7299 | 206630_at | 0.0155 | 0.9320 | |
| GSE77861 | TYR | 7299 | 206630_at | -0.2789 | 0.0293 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TYR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TYR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TYR | 7299 | 3 | 10 | 17 | |
| GSE20123 | TYR | 7299 | 3 | 10 | 17 | |
| GSE43470 | TYR | 7299 | 3 | 4 | 36 | |
| GSE46452 | TYR | 7299 | 6 | 23 | 30 | |
| GSE47630 | TYR | 7299 | 2 | 19 | 19 | |
| GSE54993 | TYR | 7299 | 8 | 2 | 60 | |
| GSE54994 | TYR | 7299 | 5 | 19 | 29 | |
| GSE60625 | TYR | 7299 | 0 | 3 | 8 | |
| GSE74703 | TYR | 7299 | 2 | 3 | 31 | |
| GSE74704 | TYR | 7299 | 3 | 6 | 11 | |
| TCGA | TYR | 7299 | 17 | 37 | 42 |
Total number of gains: 52; Total number of losses: 136; Total Number of normals: 300.
Somatic mutations of TYR:
Generating mutation plots.
Highly correlated genes for TYR:
Showing top 20/995 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TYR | FGF6 | 0.710371 | 5 | 0 | 5 |
| TYR | ADH7 | 0.695676 | 3 | 0 | 3 |
| TYR | TUB | 0.694182 | 4 | 0 | 4 |
| TYR | C5orf66-AS1 | 0.688664 | 4 | 0 | 4 |
| TYR | RABEP2 | 0.684749 | 3 | 0 | 3 |
| TYR | DENND2C | 0.683413 | 4 | 0 | 4 |
| TYR | SAMD5 | 0.679814 | 4 | 0 | 4 |
| TYR | SFTA2 | 0.678844 | 4 | 0 | 4 |
| TYR | GPT2 | 0.676814 | 3 | 0 | 3 |
| TYR | SNORA68 | 0.67515 | 4 | 0 | 4 |
| TYR | GUCY2C | 0.67494 | 3 | 0 | 3 |
| TYR | HCG22 | 0.674784 | 4 | 0 | 4 |
| TYR | FBXL16 | 0.674068 | 4 | 0 | 4 |
| TYR | GALR3 | 0.669552 | 8 | 0 | 8 |
| TYR | TMEM125 | 0.667535 | 3 | 0 | 3 |
| TYR | RNLS | 0.66454 | 3 | 0 | 3 |
| TYR | SH3BGRL2 | 0.663068 | 4 | 0 | 4 |
| TYR | CLEC4F | 0.654315 | 4 | 0 | 4 |
| TYR | ALDH3B1 | 0.653048 | 7 | 0 | 6 |
| TYR | TMEM154 | 0.65239 | 4 | 0 | 4 |
For details and further investigation, click here
