| Full name: unc-50 inner nuclear membrane RNA binding protein | Alias Symbol: URP|UNCL|GMH1 | ||
| Type: protein-coding gene | Cytoband: 2q11.2 | ||
| Entrez ID: 25972 | HGNC ID: HGNC:16046 | Ensembl Gene: ENSG00000115446 | OMIM ID: 617826 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UNC50:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UNC50 | 25972 | 203583_at | -0.0193 | 0.9822 | |
| GSE20347 | UNC50 | 25972 | 203583_at | -0.0042 | 0.9852 | |
| GSE23400 | UNC50 | 25972 | 203583_at | 0.4274 | 0.0000 | |
| GSE26886 | UNC50 | 25972 | 203583_at | -0.1220 | 0.5632 | |
| GSE29001 | UNC50 | 25972 | 203583_at | 0.1869 | 0.5931 | |
| GSE38129 | UNC50 | 25972 | 203583_at | 0.1516 | 0.1678 | |
| GSE45670 | UNC50 | 25972 | 203583_at | 0.0277 | 0.8869 | |
| GSE53622 | UNC50 | 25972 | 82893 | -0.4643 | 0.0000 | |
| GSE53624 | UNC50 | 25972 | 82893 | -0.5015 | 0.0000 | |
| GSE63941 | UNC50 | 25972 | 203583_at | -0.3657 | 0.3210 | |
| GSE77861 | UNC50 | 25972 | 203583_at | 0.1536 | 0.5121 | |
| GSE97050 | UNC50 | 25972 | A_23_P252700 | -0.2509 | 0.4610 | |
| SRP007169 | UNC50 | 25972 | RNAseq | -0.1473 | 0.6901 | |
| SRP008496 | UNC50 | 25972 | RNAseq | -0.1375 | 0.5119 | |
| SRP064894 | UNC50 | 25972 | RNAseq | 0.0192 | 0.8793 | |
| SRP133303 | UNC50 | 25972 | RNAseq | 0.1982 | 0.0129 | |
| SRP159526 | UNC50 | 25972 | RNAseq | 0.7034 | 0.0393 | |
| SRP193095 | UNC50 | 25972 | RNAseq | -0.1466 | 0.1623 | |
| SRP219564 | UNC50 | 25972 | RNAseq | -0.3980 | 0.1285 | |
| TCGA | UNC50 | 25972 | RNAseq | -0.0359 | 0.5091 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by UNC50 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UNC50:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UNC50 | 25972 | 6 | 2 | 22 | |
| GSE20123 | UNC50 | 25972 | 6 | 2 | 22 | |
| GSE43470 | UNC50 | 25972 | 3 | 2 | 38 | |
| GSE46452 | UNC50 | 25972 | 2 | 3 | 54 | |
| GSE47630 | UNC50 | 25972 | 7 | 0 | 33 | |
| GSE54993 | UNC50 | 25972 | 0 | 6 | 64 | |
| GSE54994 | UNC50 | 25972 | 10 | 0 | 43 | |
| GSE60625 | UNC50 | 25972 | 0 | 3 | 8 | |
| GSE74703 | UNC50 | 25972 | 3 | 2 | 31 | |
| GSE74704 | UNC50 | 25972 | 4 | 1 | 15 | |
| TCGA | UNC50 | 25972 | 33 | 5 | 58 |
Total number of gains: 74; Total number of losses: 26; Total Number of normals: 388.
Somatic mutations of UNC50:
Generating mutation plots.
Highly correlated genes for UNC50:
Showing top 20/236 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UNC50 | ATE1 | 0.693021 | 4 | 0 | 3 |
| UNC50 | ATF1 | 0.664086 | 7 | 0 | 5 |
| UNC50 | SGMS1 | 0.663818 | 4 | 0 | 3 |
| UNC50 | CD46 | 0.656723 | 5 | 0 | 5 |
| UNC50 | C4orf33 | 0.649573 | 3 | 0 | 3 |
| UNC50 | TMEM131 | 0.636981 | 8 | 0 | 8 |
| UNC50 | TXNDC9 | 0.63326 | 10 | 0 | 8 |
| UNC50 | DIS3L | 0.633135 | 3 | 0 | 3 |
| UNC50 | C12orf66 | 0.622997 | 3 | 0 | 3 |
| UNC50 | SAP130 | 0.622022 | 7 | 0 | 5 |
| UNC50 | CYCS | 0.620358 | 3 | 0 | 3 |
| UNC50 | MED28 | 0.611415 | 5 | 0 | 4 |
| UNC50 | ZFAND4 | 0.609982 | 4 | 0 | 4 |
| UNC50 | TRAPPC13 | 0.605855 | 4 | 0 | 3 |
| UNC50 | ETV5 | 0.598273 | 3 | 0 | 3 |
| UNC50 | VPS54 | 0.595221 | 8 | 0 | 7 |
| UNC50 | TMED10 | 0.593022 | 4 | 0 | 3 |
| UNC50 | SRP9 | 0.592918 | 9 | 0 | 6 |
| UNC50 | MFAP1 | 0.592234 | 8 | 0 | 6 |
| UNC50 | SYPL1 | 0.591971 | 5 | 0 | 3 |
For details and further investigation, click here
