| Full name: CD46 molecule | Alias Symbol: TRA2.10|MGC26544|TLX | ||
| Type: protein-coding gene | Cytoband: 1q32.2 | ||
| Entrez ID: 4179 | HGNC ID: HGNC:6953 | Ensembl Gene: ENSG00000117335 | OMIM ID: 120920 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CD46:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD46 | 4179 | 208783_s_at | 0.1540 | 0.7133 | |
| GSE20347 | CD46 | 4179 | 208783_s_at | -0.1182 | 0.2912 | |
| GSE23400 | CD46 | 4179 | 208783_s_at | -0.0551 | 0.5955 | |
| GSE26886 | CD46 | 4179 | 208783_s_at | -0.4927 | 0.0881 | |
| GSE29001 | CD46 | 4179 | 208783_s_at | -0.2970 | 0.4510 | |
| GSE38129 | CD46 | 4179 | 208783_s_at | 0.0864 | 0.5262 | |
| GSE45670 | CD46 | 4179 | 208783_s_at | 0.1263 | 0.4618 | |
| GSE53622 | CD46 | 4179 | 75932 | 0.0406 | 0.6322 | |
| GSE53624 | CD46 | 4179 | 75932 | -0.2453 | 0.0001 | |
| GSE63941 | CD46 | 4179 | 208783_s_at | 0.1824 | 0.7206 | |
| GSE77861 | CD46 | 4179 | 208783_s_at | 0.0541 | 0.8769 | |
| GSE97050 | CD46 | 4179 | A_23_P35230 | -0.1382 | 0.7069 | |
| SRP007169 | CD46 | 4179 | RNAseq | -0.7979 | 0.1095 | |
| SRP008496 | CD46 | 4179 | RNAseq | -0.7808 | 0.0211 | |
| SRP064894 | CD46 | 4179 | RNAseq | -0.4653 | 0.0839 | |
| SRP133303 | CD46 | 4179 | RNAseq | 0.0410 | 0.7822 | |
| SRP159526 | CD46 | 4179 | RNAseq | -0.2856 | 0.5432 | |
| SRP193095 | CD46 | 4179 | RNAseq | -0.5157 | 0.0002 | |
| SRP219564 | CD46 | 4179 | RNAseq | -0.2411 | 0.5573 | |
| TCGA | CD46 | 4179 | RNAseq | -0.0651 | 0.1591 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CD46 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CD46:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CD46 | 4179 | 11 | 0 | 19 | |
| GSE20123 | CD46 | 4179 | 11 | 0 | 19 | |
| GSE43470 | CD46 | 4179 | 9 | 0 | 34 | |
| GSE46452 | CD46 | 4179 | 3 | 1 | 55 | |
| GSE47630 | CD46 | 4179 | 14 | 0 | 26 | |
| GSE54993 | CD46 | 4179 | 0 | 6 | 64 | |
| GSE54994 | CD46 | 4179 | 14 | 0 | 39 | |
| GSE60625 | CD46 | 4179 | 0 | 0 | 11 | |
| GSE74703 | CD46 | 4179 | 9 | 0 | 27 | |
| GSE74704 | CD46 | 4179 | 5 | 0 | 15 | |
| TCGA | CD46 | 4179 | 45 | 3 | 48 |
Total number of gains: 121; Total number of losses: 10; Total Number of normals: 357.
Somatic mutations of CD46:
Generating mutation plots.
Highly correlated genes for CD46:
Showing top 20/171 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD46 | YY1AP1 | 0.689901 | 3 | 0 | 3 |
| CD46 | RBM8A | 0.661295 | 5 | 0 | 4 |
| CD46 | ILDR1 | 0.65861 | 3 | 0 | 3 |
| CD46 | BROX | 0.657775 | 7 | 0 | 6 |
| CD46 | UNC50 | 0.656723 | 5 | 0 | 5 |
| CD46 | DCUN1D4 | 0.656262 | 3 | 0 | 3 |
| CD46 | SCYL3 | 0.653992 | 8 | 0 | 8 |
| CD46 | GDAP2 | 0.653688 | 3 | 0 | 3 |
| CD46 | LCORL | 0.645544 | 3 | 0 | 3 |
| CD46 | RNF8 | 0.632825 | 4 | 0 | 4 |
| CD46 | ATG3 | 0.632795 | 4 | 0 | 4 |
| CD46 | KLHL12 | 0.631475 | 4 | 0 | 3 |
| CD46 | LCOR | 0.626646 | 6 | 0 | 5 |
| CD46 | RNASEL | 0.625267 | 4 | 0 | 3 |
| CD46 | POLR3B | 0.624027 | 3 | 0 | 3 |
| CD46 | TPD52 | 0.620751 | 4 | 0 | 3 |
| CD46 | MICU2 | 0.615187 | 3 | 0 | 3 |
| CD46 | TSPAN5 | 0.60886 | 3 | 0 | 3 |
| CD46 | ESRP1 | 0.606927 | 5 | 0 | 4 |
| CD46 | PDCD10 | 0.606795 | 4 | 0 | 3 |
For details and further investigation, click here
