| Full name: cyclin dependent kinase 17 | Alias Symbol: PCTAIRE2 | ||
| Type: protein-coding gene | Cytoband: 12q23.1 | ||
| Entrez ID: 5128 | HGNC ID: HGNC:8750 | Ensembl Gene: ENSG00000059758 | OMIM ID: 603440 |
| Drug and gene relationship at DGIdb | |||
Expression of CDK17:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDK17 | 5128 | 221918_at | 0.0145 | 0.9779 | |
| GSE20347 | CDK17 | 5128 | 221918_at | 0.4078 | 0.0291 | |
| GSE23400 | CDK17 | 5128 | 221918_at | 0.3298 | 0.0001 | |
| GSE26886 | CDK17 | 5128 | 221918_at | 0.1717 | 0.4400 | |
| GSE29001 | CDK17 | 5128 | 221918_at | 0.5070 | 0.0440 | |
| GSE38129 | CDK17 | 5128 | 221918_at | 0.2029 | 0.1360 | |
| GSE45670 | CDK17 | 5128 | 221918_at | -0.0164 | 0.9253 | |
| GSE53622 | CDK17 | 5128 | 26762 | 0.0154 | 0.8898 | |
| GSE53624 | CDK17 | 5128 | 26762 | 0.1830 | 0.0194 | |
| GSE63941 | CDK17 | 5128 | 221918_at | -1.2470 | 0.0054 | |
| GSE77861 | CDK17 | 5128 | 221918_at | 0.5761 | 0.0283 | |
| GSE97050 | CDK17 | 5128 | A_33_P3341224 | 0.0778 | 0.6977 | |
| SRP007169 | CDK17 | 5128 | RNAseq | 0.4103 | 0.2307 | |
| SRP008496 | CDK17 | 5128 | RNAseq | 0.7205 | 0.0030 | |
| SRP064894 | CDK17 | 5128 | RNAseq | 0.0107 | 0.9741 | |
| SRP133303 | CDK17 | 5128 | RNAseq | 0.3873 | 0.0046 | |
| SRP159526 | CDK17 | 5128 | RNAseq | 0.1649 | 0.6459 | |
| SRP193095 | CDK17 | 5128 | RNAseq | 0.4578 | 0.0000 | |
| SRP219564 | CDK17 | 5128 | RNAseq | 0.0068 | 0.9885 | |
| TCGA | CDK17 | 5128 | RNAseq | -0.0546 | 0.3147 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CDK17 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDK17:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDK17 | 5128 | 3 | 2 | 25 | |
| GSE20123 | CDK17 | 5128 | 3 | 2 | 25 | |
| GSE43470 | CDK17 | 5128 | 3 | 0 | 40 | |
| GSE46452 | CDK17 | 5128 | 9 | 1 | 49 | |
| GSE47630 | CDK17 | 5128 | 9 | 1 | 30 | |
| GSE54993 | CDK17 | 5128 | 0 | 5 | 65 | |
| GSE54994 | CDK17 | 5128 | 4 | 1 | 48 | |
| GSE60625 | CDK17 | 5128 | 0 | 0 | 11 | |
| GSE74703 | CDK17 | 5128 | 3 | 0 | 33 | |
| GSE74704 | CDK17 | 5128 | 1 | 2 | 17 | |
| TCGA | CDK17 | 5128 | 18 | 10 | 68 |
Total number of gains: 53; Total number of losses: 24; Total Number of normals: 411.
Somatic mutations of CDK17:
Generating mutation plots.
Highly correlated genes for CDK17:
Showing top 20/98 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDK17 | TIMM22 | 0.68879 | 3 | 0 | 3 |
| CDK17 | ADAMTS6 | 0.655995 | 3 | 0 | 3 |
| CDK17 | CCDC43 | 0.6373 | 3 | 0 | 3 |
| CDK17 | COL3A1 | 0.630448 | 6 | 0 | 5 |
| CDK17 | FN1 | 0.621391 | 6 | 0 | 5 |
| CDK17 | LUM | 0.619271 | 6 | 0 | 5 |
| CDK17 | SMIM3 | 0.618208 | 3 | 0 | 3 |
| CDK17 | POSTN | 0.61479 | 6 | 0 | 5 |
| CDK17 | FBN1 | 0.613753 | 6 | 0 | 5 |
| CDK17 | COL6A3 | 0.613286 | 6 | 0 | 4 |
| CDK17 | NID2 | 0.608426 | 7 | 0 | 6 |
| CDK17 | CSGALNACT2 | 0.605361 | 9 | 0 | 6 |
| CDK17 | COL5A2 | 0.601985 | 6 | 0 | 4 |
| CDK17 | CHN1 | 0.601225 | 6 | 0 | 4 |
| CDK17 | GREM1 | 0.60042 | 5 | 0 | 4 |
| CDK17 | FAP | 0.599969 | 6 | 0 | 5 |
| CDK17 | RASL11B | 0.594685 | 4 | 0 | 3 |
| CDK17 | SULF1 | 0.59351 | 6 | 0 | 5 |
| CDK17 | UBE2Q1 | 0.590608 | 4 | 0 | 3 |
| CDK17 | SLC38A2 | 0.588516 | 5 | 0 | 4 |
For details and further investigation, click here
