| Full name: vascular endothelial growth factor A | Alias Symbol: VEGF-A|VPF | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 7422 | HGNC ID: HGNC:12680 | Ensembl Gene: ENSG00000112715 | OMIM ID: 192240 |
| Drug and gene relationship at DGIdb | |||
VEGFA involved pathways:
Expression of VEGFA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VEGFA | 7422 | 210512_s_at | -0.0394 | 0.9729 | |
| GSE20347 | VEGFA | 7422 | 210512_s_at | 0.5937 | 0.0300 | |
| GSE23400 | VEGFA | 7422 | 210512_s_at | 0.6380 | 0.0000 | |
| GSE26886 | VEGFA | 7422 | 210512_s_at | 0.3828 | 0.3861 | |
| GSE29001 | VEGFA | 7422 | 210512_s_at | 0.2211 | 0.5353 | |
| GSE38129 | VEGFA | 7422 | 210512_s_at | 0.5792 | 0.0122 | |
| GSE45670 | VEGFA | 7422 | 210512_s_at | 0.5762 | 0.0286 | |
| GSE53622 | VEGFA | 7422 | 113878 | 0.6910 | 0.0000 | |
| GSE53624 | VEGFA | 7422 | 113878 | 0.8349 | 0.0000 | |
| GSE63941 | VEGFA | 7422 | 210512_s_at | 0.4239 | 0.6450 | |
| GSE77861 | VEGFA | 7422 | 210512_s_at | 0.6367 | 0.1149 | |
| GSE97050 | VEGFA | 7422 | A_23_P70398 | 1.0830 | 0.0555 | |
| SRP007169 | VEGFA | 7422 | RNAseq | 0.2237 | 0.5744 | |
| SRP008496 | VEGFA | 7422 | RNAseq | 0.2990 | 0.2294 | |
| SRP064894 | VEGFA | 7422 | RNAseq | 0.4115 | 0.2554 | |
| SRP133303 | VEGFA | 7422 | RNAseq | 1.0582 | 0.0001 | |
| SRP159526 | VEGFA | 7422 | RNAseq | 0.1285 | 0.8098 | |
| SRP193095 | VEGFA | 7422 | RNAseq | 0.6302 | 0.0002 | |
| SRP219564 | VEGFA | 7422 | RNAseq | 0.5186 | 0.3583 | |
| TCGA | VEGFA | 7422 | RNAseq | 0.0161 | 0.8331 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by VEGFA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VEGFA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VEGFA | 7422 | 7 | 0 | 23 | |
| GSE20123 | VEGFA | 7422 | 7 | 0 | 23 | |
| GSE43470 | VEGFA | 7422 | 6 | 0 | 37 | |
| GSE46452 | VEGFA | 7422 | 3 | 9 | 47 | |
| GSE47630 | VEGFA | 7422 | 8 | 4 | 28 | |
| GSE54993 | VEGFA | 7422 | 3 | 2 | 65 | |
| GSE54994 | VEGFA | 7422 | 10 | 4 | 39 | |
| GSE60625 | VEGFA | 7422 | 0 | 1 | 10 | |
| GSE74703 | VEGFA | 7422 | 6 | 0 | 30 | |
| GSE74704 | VEGFA | 7422 | 3 | 0 | 17 | |
| TCGA | VEGFA | 7422 | 22 | 11 | 63 |
Total number of gains: 75; Total number of losses: 31; Total Number of normals: 382.
Somatic mutations of VEGFA:
Generating mutation plots.
Highly correlated genes for VEGFA:
Showing top 20/132 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VEGFA | LILRA4 | 0.686512 | 3 | 0 | 3 |
| VEGFA | RBM34 | 0.677943 | 3 | 0 | 3 |
| VEGFA | PLEKHG1 | 0.650887 | 3 | 0 | 3 |
| VEGFA | AMIGO2 | 0.650704 | 3 | 0 | 3 |
| VEGFA | B3GNT5 | 0.638309 | 4 | 0 | 4 |
| VEGFA | ZBTB11 | 0.634272 | 4 | 0 | 4 |
| VEGFA | PPP6R3 | 0.626382 | 3 | 0 | 3 |
| VEGFA | CPNE8 | 0.625399 | 3 | 0 | 3 |
| VEGFA | SEC61G | 0.612872 | 5 | 0 | 3 |
| VEGFA | COPS8 | 0.611313 | 4 | 0 | 3 |
| VEGFA | NSMCE2 | 0.60963 | 4 | 0 | 3 |
| VEGFA | RNF145 | 0.608118 | 4 | 0 | 3 |
| VEGFA | FZD6 | 0.602701 | 5 | 0 | 4 |
| VEGFA | UBA6 | 0.59772 | 5 | 0 | 3 |
| VEGFA | SLC6A15 | 0.59396 | 4 | 0 | 3 |
| VEGFA | JAG1 | 0.583947 | 4 | 0 | 3 |
| VEGFA | MRPL36 | 0.579267 | 4 | 0 | 3 |
| VEGFA | SLC2A1 | 0.579184 | 11 | 0 | 9 |
| VEGFA | POTEM | 0.576118 | 4 | 0 | 3 |
| VEGFA | KRTAP4-3 | 0.575024 | 3 | 0 | 3 |
For details and further investigation, click here
