CTSS

 

Full name: cathepsin S Alias Symbol: 
Type: protein-coding gene Cytoband: 1q21.3
Entrez ID: 1520 HGNC ID: HGNC:2545 Ensembl Gene: ENSG00000163131 OMIM ID: 116845
Drug and gene relationship at DGIdb

 

CTSS involved pathways:

KEGG pathway Description View
hsa04210Apoptosis
hsa04612Antigen processing and presentation
hsa05152Tuberculosis

 

Expression of CTSS:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CTSS 1520 202902_s_at -0.2991 0.8516
GSE20347 CTSS 1520 202902_s_at -0.6377 0.0297
GSE23400 CTSS 1520 202902_s_at 0.1512 0.2600
GSE26886 CTSS 1520 232617_at -0.6464 0.0870
GSE29001 CTSS 1520 202902_s_at -0.2734 0.3953
GSE38129 CTSS 1520 202902_s_at -0.2698 0.4205
GSE45670 CTSS 1520 232617_at -0.4236 0.1572
GSE53622 CTSS 1520 142009 0.2297 0.1034
GSE53624 CTSS 1520 142009 0.0914 0.5354
GSE63941 CTSS 1520 202902_s_at 0.6810 0.6939
GSE77861 CTSS 1520 232617_at -0.3430 0.0861
GSE97050 CTSS 1520 A_24_P242646 0.5860 0.1314
SRP007169 CTSS 1520 RNAseq 0.9821 0.1707
SRP008496 CTSS 1520 RNAseq -0.4029 0.0287
SRP064894 CTSS 1520 RNAseq 1.0808 0.0028
SRP133303 CTSS 1520 RNAseq 0.4218 0.0812
SRP159526 CTSS 1520 RNAseq 0.0895 0.9128
SRP193095 CTSS 1520 RNAseq -0.2786 0.2975
SRP219564 CTSS 1520 RNAseq 1.0283 0.0298
TCGA CTSS 1520 RNAseq -0.1422 0.1642

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by CTSS expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CTSS:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CTSS 1520 15 0 15
GSE20123 CTSS 1520 15 0 15
GSE43470 CTSS 1520 6 1 36
GSE46452 CTSS 1520 2 1 56
GSE47630 CTSS 1520 14 0 26
GSE54993 CTSS 1520 0 3 67
GSE54994 CTSS 1520 15 0 38
GSE60625 CTSS 1520 0 0 11
GSE74703 CTSS 1520 6 1 29
GSE74704 CTSS 1520 7 0 13
TCGA CTSS 1520 38 2 56

Total number of gains: 118; Total number of losses: 8; Total Number of normals: 362.  

 

Somatic mutations of CTSS:

 

Generating mutation plots.

 

Highly correlated genes for CTSS:

 

Showing top 20/493 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CTSSMPEG10.79013505
CTSSC3orf800.740682303
CTSSSGMS20.733879303
CTSSPIK3R50.728397504
CTSSTNFAIP8L20.720011504
CTSSEVI2A0.718272909
CTSSITGB20.7150661009
CTSSHLA-DMB0.7059781008
CTSSGNG20.701598303
CTSSRCSD10.701487606
CTSSRGS180.701257606
CTSSEVI2B0.70109611010
CTSSCD79B0.696995303
CTSSNCKAP1L0.694403807
CTSSHFE0.693422303
CTSSALOX50.6917931009
CTSSDOCK20.6914571009
CTSSLAPTM50.6913081109
CTSSCD530.6902861008
CTSSITGAM0.688137605

For details and further investigation, click here