PLK4

 

Full name: polo like kinase 4 Alias Symbol: Sak
Type: protein-coding gene Cytoband: 4q28.1
Entrez ID: 10733 HGNC ID: HGNC:11397 Ensembl Gene: ENSG00000142731 OMIM ID: 605031
Drug and gene relationship at DGIdb
Screen Evidence:

 

PLK4 involved pathways:

KEGG pathway Description View
hsa04068FoxO signaling pathway

 

Expression of PLK4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PLK4 10733 204887_s_at 0.8116 0.1719
GSE20347 PLK4 10733 204887_s_at 0.7066 0.0001
GSE23400 PLK4 10733 204887_s_at 0.5429 0.0000
GSE26886 PLK4 10733 204887_s_at -0.2805 0.2185
GSE29001 PLK4 10733 204886_at 0.7209 0.0078
GSE38129 PLK4 10733 204887_s_at 0.8667 0.0000
GSE45670 PLK4 10733 204887_s_at 0.7143 0.0005
GSE53622 PLK4 10733 19085 1.0834 0.0000
GSE53624 PLK4 10733 19085 1.2365 0.0000
GSE63941 PLK4 10733 204887_s_at 2.6320 0.0000
GSE77861 PLK4 10733 204887_s_at 0.2428 0.3558
GSE97050 PLK4 10733 A_23_P155969 0.5847 0.5183
SRP007169 PLK4 10733 RNAseq 0.9894 0.0352
SRP008496 PLK4 10733 RNAseq 0.7952 0.0190
SRP064894 PLK4 10733 RNAseq 0.8390 0.0093
SRP133303 PLK4 10733 RNAseq 1.4819 0.0000
SRP159526 PLK4 10733 RNAseq 0.6286 0.1119
SRP193095 PLK4 10733 RNAseq 0.5607 0.0006
SRP219564 PLK4 10733 RNAseq 0.5070 0.4018
TCGA PLK4 10733 RNAseq 1.0144 0.0000

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by PLK4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PLK4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PLK4 10733 0 12 18
GSE20123 PLK4 10733 0 12 18
GSE43470 PLK4 10733 0 13 30
GSE46452 PLK4 10733 1 36 22
GSE47630 PLK4 10733 0 22 18
GSE54993 PLK4 10733 9 0 61
GSE54994 PLK4 10733 1 11 41
GSE60625 PLK4 10733 0 1 10
GSE74703 PLK4 10733 0 11 25
GSE74704 PLK4 10733 0 6 14
TCGA PLK4 10733 8 35 53

Total number of gains: 19; Total number of losses: 159; Total Number of normals: 310.  

 

Somatic mutations of PLK4:

 

Generating mutation plots.

 

Highly correlated genes for PLK4:

 

Showing top 20/517 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PLK4MAD2L10.80166612012
PLK4KIF150.7948610010
PLK4PLK10.786248808
PLK4CDK10.77352211011
PLK4CCNA20.7724712011
PLK4TRIP130.761267909
PLK4CDKN30.74783811011
PLK4NCAPH0.743738807
PLK4CHEK10.74042611011
PLK4RRM20.73786811010
PLK4CKS1B0.73618511011
PLK4CENPF0.7356991009
PLK4ECT20.73550711010
PLK4RAD51AP10.73405112010
PLK4CCNB10.73011511010
PLK4CENPN0.73009111010
PLK4TPX20.72911311010
PLK4DLGAP50.72828512010
PLK4NDC10.72709510010
PLK4AURKB0.72511710010

For details and further investigation, click here