| Full name: cyclic nucleotide gated channel subunit alpha 1 | Alias Symbol: RCNC1|RCNCa|CNG1|RP49 | ||
| Type: protein-coding gene | Cytoband: 4p12 | ||
| Entrez ID: 1259 | HGNC ID: HGNC:2148 | Ensembl Gene: ENSG00000198515 | OMIM ID: 123825 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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CNGA1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04022 | cGMP-PKG signaling pathway | |
| hsa04024 | cAMP signaling pathway |
Expression of CNGA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CNGA1 | 1259 | 206417_at | -0.2659 | 0.7485 | |
| GSE20347 | CNGA1 | 1259 | 206417_at | -0.9875 | 0.0000 | |
| GSE23400 | CNGA1 | 1259 | 206417_at | -0.4308 | 0.0000 | |
| GSE26886 | CNGA1 | 1259 | 206417_at | -1.7783 | 0.0000 | |
| GSE29001 | CNGA1 | 1259 | 206417_at | -1.5205 | 0.0000 | |
| GSE38129 | CNGA1 | 1259 | 206417_at | -0.8048 | 0.0000 | |
| GSE45670 | CNGA1 | 1259 | 206417_at | -0.8515 | 0.0304 | |
| GSE53622 | CNGA1 | 1259 | 9003 | -1.4818 | 0.0000 | |
| GSE53624 | CNGA1 | 1259 | 9003 | -2.9329 | 0.0000 | |
| GSE63941 | CNGA1 | 1259 | 206417_at | 0.4298 | 0.3654 | |
| GSE77861 | CNGA1 | 1259 | 206417_at | -0.5071 | 0.0603 | |
| GSE97050 | CNGA1 | 1259 | A_23_P92536 | 0.0221 | 0.9671 | |
| SRP064894 | CNGA1 | 1259 | RNAseq | -2.5819 | 0.0000 | |
| SRP133303 | CNGA1 | 1259 | RNAseq | -1.6207 | 0.0000 | |
| SRP159526 | CNGA1 | 1259 | RNAseq | -3.2772 | 0.0000 | |
| SRP193095 | CNGA1 | 1259 | RNAseq | -1.8736 | 0.0000 | |
| SRP219564 | CNGA1 | 1259 | RNAseq | -1.8040 | 0.0098 | |
| TCGA | CNGA1 | 1259 | RNAseq | -0.4146 | 0.1345 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by CNGA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CNGA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CNGA1 | 1259 | 1 | 15 | 14 | |
| GSE20123 | CNGA1 | 1259 | 1 | 15 | 14 | |
| GSE43470 | CNGA1 | 1259 | 0 | 13 | 30 | |
| GSE46452 | CNGA1 | 1259 | 1 | 37 | 21 | |
| GSE47630 | CNGA1 | 1259 | 1 | 18 | 21 | |
| GSE54993 | CNGA1 | 1259 | 7 | 0 | 63 | |
| GSE54994 | CNGA1 | 1259 | 4 | 9 | 40 | |
| GSE60625 | CNGA1 | 1259 | 0 | 0 | 11 | |
| GSE74703 | CNGA1 | 1259 | 0 | 11 | 25 | |
| GSE74704 | CNGA1 | 1259 | 0 | 9 | 11 | |
| TCGA | CNGA1 | 1259 | 18 | 30 | 48 |
Total number of gains: 33; Total number of losses: 157; Total Number of normals: 298.
Somatic mutations of CNGA1:
Generating mutation plots.
Highly correlated genes for CNGA1:
Showing top 20/1271 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CNGA1 | MXD1 | 0.782222 | 9 | 0 | 9 |
| CNGA1 | PADI1 | 0.781199 | 7 | 0 | 7 |
| CNGA1 | SASH1 | 0.765315 | 10 | 0 | 10 |
| CNGA1 | FBXO34 | 0.748449 | 9 | 0 | 9 |
| CNGA1 | VPS4B | 0.746159 | 10 | 0 | 10 |
| CNGA1 | C18orf25 | 0.744705 | 10 | 0 | 10 |
| CNGA1 | VSIG2 | 0.743458 | 5 | 0 | 5 |
| CNGA1 | S100A14 | 0.742047 | 9 | 0 | 9 |
| CNGA1 | SLC10A5 | 0.740583 | 3 | 0 | 3 |
| CNGA1 | RAB10 | 0.73847 | 5 | 0 | 5 |
| CNGA1 | EPB41L4A | 0.73781 | 8 | 0 | 8 |
| CNGA1 | PMM1 | 0.737268 | 9 | 0 | 9 |
| CNGA1 | TTC9 | 0.735959 | 10 | 0 | 10 |
| CNGA1 | FNDC4 | 0.735553 | 9 | 0 | 9 |
| CNGA1 | CAST | 0.732693 | 10 | 0 | 10 |
| CNGA1 | A2ML1 | 0.732178 | 5 | 0 | 5 |
| CNGA1 | YOD1 | 0.731902 | 10 | 0 | 10 |
| CNGA1 | TP53I3 | 0.731129 | 10 | 0 | 10 |
| CNGA1 | GDPD3 | 0.731128 | 11 | 0 | 11 |
| CNGA1 | EMC3 | 0.730522 | 9 | 0 | 9 |
For details and further investigation, click here
