| Full name: diablo IAP-binding mitochondrial protein | Alias Symbol: SMAC|DIABLO-S|FLJ25049|FLJ10537|DFNA64 | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 56616 | HGNC ID: HGNC:21528 | Ensembl Gene: ENSG00000184047 | OMIM ID: 605219 |
| Drug and gene relationship at DGIdb | |||
DIABLO involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04210 | Apoptosis |
Expression of DIABLO:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DIABLO | 56616 | 219350_s_at | 0.5817 | 0.1029 | |
| GSE20347 | DIABLO | 56616 | 219350_s_at | 0.6224 | 0.0001 | |
| GSE23400 | DIABLO | 56616 | 219350_s_at | 0.3740 | 0.0000 | |
| GSE26886 | DIABLO | 56616 | 219350_s_at | 0.8038 | 0.0000 | |
| GSE29001 | DIABLO | 56616 | 219350_s_at | 0.5573 | 0.0006 | |
| GSE38129 | DIABLO | 56616 | 219350_s_at | 0.6367 | 0.0000 | |
| GSE45670 | DIABLO | 56616 | 219350_s_at | 0.4664 | 0.0000 | |
| GSE53622 | DIABLO | 56616 | 11146 | -0.1066 | 0.0381 | |
| GSE53624 | DIABLO | 56616 | 11146 | -0.1774 | 0.0004 | |
| GSE63941 | DIABLO | 56616 | 219350_s_at | 0.4044 | 0.1570 | |
| GSE77861 | DIABLO | 56616 | 219350_s_at | 0.5680 | 0.0009 | |
| GSE97050 | DIABLO | 56616 | A_33_P3330125 | -0.0247 | 0.9163 | |
| SRP007169 | DIABLO | 56616 | RNAseq | 0.9336 | 0.0094 | |
| SRP008496 | DIABLO | 56616 | RNAseq | 0.8199 | 0.0014 | |
| SRP064894 | DIABLO | 56616 | RNAseq | 0.5497 | 0.0033 | |
| SRP133303 | DIABLO | 56616 | RNAseq | 0.5731 | 0.0000 | |
| SRP159526 | DIABLO | 56616 | RNAseq | 0.4663 | 0.0431 | |
| SRP193095 | DIABLO | 56616 | RNAseq | 0.2200 | 0.0199 | |
| SRP219564 | DIABLO | 56616 | RNAseq | 0.3459 | 0.2514 | |
| TCGA | DIABLO | 56616 | RNAseq | 0.1985 | 0.0009 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DIABLO expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DIABLO:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DIABLO | 56616 | 5 | 4 | 21 | |
| GSE20123 | DIABLO | 56616 | 5 | 4 | 21 | |
| GSE43470 | DIABLO | 56616 | 2 | 2 | 39 | |
| GSE46452 | DIABLO | 56616 | 9 | 1 | 49 | |
| GSE47630 | DIABLO | 56616 | 9 | 3 | 28 | |
| GSE54993 | DIABLO | 56616 | 0 | 5 | 65 | |
| GSE54994 | DIABLO | 56616 | 5 | 7 | 41 | |
| GSE60625 | DIABLO | 56616 | 0 | 0 | 11 | |
| GSE74703 | DIABLO | 56616 | 2 | 1 | 33 | |
| GSE74704 | DIABLO | 56616 | 4 | 2 | 14 | |
| TCGA | DIABLO | 56616 | 21 | 10 | 65 |
Total number of gains: 62; Total number of losses: 39; Total Number of normals: 387.
Somatic mutations of DIABLO:
Generating mutation plots.
Highly correlated genes for DIABLO:
Showing top 20/322 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DIABLO | APMAP | 0.765524 | 8 | 0 | 8 |
| DIABLO | HOXC9 | 0.725834 | 5 | 0 | 5 |
| DIABLO | ABCA13 | 0.714892 | 3 | 0 | 3 |
| DIABLO | CDCA5 | 0.710466 | 5 | 0 | 5 |
| DIABLO | GRIK4 | 0.699343 | 3 | 0 | 3 |
| DIABLO | FBRSL1 | 0.697172 | 5 | 0 | 5 |
| DIABLO | FOXM1 | 0.691586 | 8 | 0 | 8 |
| DIABLO | UHRF1 | 0.686739 | 4 | 0 | 3 |
| DIABLO | SLC39A5 | 0.685882 | 3 | 0 | 3 |
| DIABLO | RANBP1 | 0.684589 | 9 | 0 | 8 |
| DIABLO | BID | 0.684564 | 8 | 0 | 8 |
| DIABLO | FSCN1 | 0.683585 | 7 | 0 | 7 |
| DIABLO | TRIP13 | 0.681096 | 8 | 0 | 8 |
| DIABLO | CASKIN1 | 0.679569 | 5 | 0 | 4 |
| DIABLO | STPG1 | 0.67819 | 3 | 0 | 3 |
| DIABLO | FAM24B | 0.675114 | 3 | 0 | 3 |
| DIABLO | UBE2S | 0.674699 | 8 | 0 | 8 |
| DIABLO | CDCA8 | 0.67216 | 8 | 0 | 7 |
| DIABLO | ATP6V0A2 | 0.671564 | 6 | 0 | 5 |
| DIABLO | WDR66 | 0.670774 | 5 | 0 | 3 |
For details and further investigation, click here
