| Full name: ephrin B3 | Alias Symbol: LERK-8 | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 1949 | HGNC ID: HGNC:3228 | Ensembl Gene: ENSG00000108947 | OMIM ID: 602297 |
| Drug and gene relationship at DGIdb | |||
EFNB3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of EFNB3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EFNB3 | 1949 | 205031_at | 0.3704 | 0.5730 | |
| GSE20347 | EFNB3 | 1949 | 205031_at | 0.0630 | 0.7699 | |
| GSE23400 | EFNB3 | 1949 | 205031_at | -0.0648 | 0.2360 | |
| GSE26886 | EFNB3 | 1949 | 205031_at | 0.6659 | 0.1373 | |
| GSE29001 | EFNB3 | 1949 | 205031_at | -0.0199 | 0.9606 | |
| GSE38129 | EFNB3 | 1949 | 205031_at | 0.3436 | 0.0916 | |
| GSE45670 | EFNB3 | 1949 | 205031_at | 0.0483 | 0.8533 | |
| GSE53622 | EFNB3 | 1949 | 101304 | 0.7197 | 0.0005 | |
| GSE53624 | EFNB3 | 1949 | 51293 | 0.0856 | 0.6139 | |
| GSE63941 | EFNB3 | 1949 | 205031_at | 0.4867 | 0.6377 | |
| GSE77861 | EFNB3 | 1949 | 210883_x_at | 0.0288 | 0.8433 | |
| GSE97050 | EFNB3 | 1949 | A_24_P940006 | 0.2675 | 0.5572 | |
| SRP007169 | EFNB3 | 1949 | RNAseq | 0.1968 | 0.8076 | |
| SRP064894 | EFNB3 | 1949 | RNAseq | 0.5856 | 0.0527 | |
| SRP133303 | EFNB3 | 1949 | RNAseq | 0.2836 | 0.5126 | |
| SRP159526 | EFNB3 | 1949 | RNAseq | 1.2456 | 0.0577 | |
| SRP219564 | EFNB3 | 1949 | RNAseq | 0.2952 | 0.7159 | |
| TCGA | EFNB3 | 1949 | RNAseq | 0.5564 | 0.0197 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EFNB3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EFNB3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EFNB3 | 1949 | 4 | 2 | 24 | |
| GSE20123 | EFNB3 | 1949 | 4 | 3 | 23 | |
| GSE43470 | EFNB3 | 1949 | 1 | 6 | 36 | |
| GSE46452 | EFNB3 | 1949 | 34 | 1 | 24 | |
| GSE47630 | EFNB3 | 1949 | 7 | 1 | 32 | |
| GSE54993 | EFNB3 | 1949 | 4 | 3 | 63 | |
| GSE54994 | EFNB3 | 1949 | 5 | 8 | 40 | |
| GSE60625 | EFNB3 | 1949 | 4 | 0 | 7 | |
| GSE74703 | EFNB3 | 1949 | 1 | 3 | 32 | |
| GSE74704 | EFNB3 | 1949 | 2 | 1 | 17 | |
| TCGA | EFNB3 | 1949 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 49; Total Number of normals: 356.
Somatic mutations of EFNB3:
Generating mutation plots.
Highly correlated genes for EFNB3:
Showing top 20/73 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EFNB3 | ARHGEF16 | 0.712961 | 3 | 0 | 3 |
| EFNB3 | KHNYN | 0.684317 | 3 | 0 | 3 |
| EFNB3 | MRPS28 | 0.658558 | 3 | 0 | 3 |
| EFNB3 | COL23A1 | 0.646464 | 3 | 0 | 3 |
| EFNB3 | ZBED1 | 0.637963 | 3 | 0 | 3 |
| EFNB3 | DAP | 0.634656 | 3 | 0 | 3 |
| EFNB3 | MANEA | 0.630223 | 4 | 0 | 3 |
| EFNB3 | PFN2 | 0.629186 | 3 | 0 | 3 |
| EFNB3 | FKBP11 | 0.628244 | 3 | 0 | 3 |
| EFNB3 | SFT2D3 | 0.622741 | 3 | 0 | 3 |
| EFNB3 | ADAP2 | 0.621053 | 3 | 0 | 3 |
| EFNB3 | ABCC4 | 0.620662 | 3 | 0 | 3 |
| EFNB3 | CDC40 | 0.618404 | 3 | 0 | 3 |
| EFNB3 | SCN8A | 0.610562 | 4 | 0 | 4 |
| EFNB3 | SCPEP1 | 0.608524 | 5 | 0 | 3 |
| EFNB3 | DHX57 | 0.598846 | 3 | 0 | 3 |
| EFNB3 | TET1 | 0.594277 | 4 | 0 | 3 |
| EFNB3 | METTL3 | 0.593933 | 3 | 0 | 3 |
| EFNB3 | ETNK2 | 0.592062 | 4 | 0 | 3 |
| EFNB3 | SF3A2 | 0.590595 | 3 | 0 | 3 |
For details and further investigation, click here
