| Full name: endoplasmic reticulum aminopeptidase 2 | Alias Symbol: L-RAP|LRAP | ||
| Type: protein-coding gene | Cytoband: 5q15 | ||
| Entrez ID: 64167 | HGNC ID: HGNC:29499 | Ensembl Gene: ENSG00000164308 | OMIM ID: 609497 |
| Drug and gene relationship at DGIdb | |||
Expression of ERAP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ERAP2 | 64167 | 227462_at | 0.5734 | 0.7379 | |
| GSE20347 | ERAP2 | 64167 | 219759_at | 0.2164 | 0.7491 | |
| GSE23400 | ERAP2 | 64167 | 219759_at | 0.3560 | 0.0825 | |
| GSE26886 | ERAP2 | 64167 | 227462_at | 0.5115 | 0.5516 | |
| GSE29001 | ERAP2 | 64167 | 219759_at | 0.3294 | 0.5451 | |
| GSE38129 | ERAP2 | 64167 | 219759_at | 0.1746 | 0.7161 | |
| GSE45670 | ERAP2 | 64167 | 227462_at | 0.4766 | 0.5158 | |
| GSE53622 | ERAP2 | 64167 | 10797 | 0.1682 | 0.6165 | |
| GSE53624 | ERAP2 | 64167 | 10797 | 0.2467 | 0.2371 | |
| GSE63941 | ERAP2 | 64167 | 227462_at | -1.4334 | 0.4037 | |
| GSE77861 | ERAP2 | 64167 | 219759_at | -0.2725 | 0.3182 | |
| GSE97050 | ERAP2 | 64167 | A_23_P30243 | 0.1338 | 0.6217 | |
| SRP007169 | ERAP2 | 64167 | RNAseq | -1.0254 | 0.1045 | |
| SRP064894 | ERAP2 | 64167 | RNAseq | 0.5612 | 0.1474 | |
| SRP133303 | ERAP2 | 64167 | RNAseq | 0.9666 | 0.0877 | |
| SRP159526 | ERAP2 | 64167 | RNAseq | -0.1895 | 0.6857 | |
| SRP193095 | ERAP2 | 64167 | RNAseq | 0.2035 | 0.4585 | |
| SRP219564 | ERAP2 | 64167 | RNAseq | 1.1500 | 0.0172 | |
| TCGA | ERAP2 | 64167 | RNAseq | 0.0060 | 0.9729 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ERAP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ERAP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ERAP2 | 64167 | 1 | 13 | 16 | |
| GSE20123 | ERAP2 | 64167 | 1 | 13 | 16 | |
| GSE43470 | ERAP2 | 64167 | 3 | 9 | 31 | |
| GSE46452 | ERAP2 | 64167 | 0 | 28 | 31 | |
| GSE47630 | ERAP2 | 64167 | 0 | 20 | 20 | |
| GSE54993 | ERAP2 | 64167 | 8 | 1 | 61 | |
| GSE54994 | ERAP2 | 64167 | 1 | 18 | 34 | |
| GSE60625 | ERAP2 | 64167 | 0 | 0 | 11 | |
| GSE74703 | ERAP2 | 64167 | 2 | 7 | 27 | |
| GSE74704 | ERAP2 | 64167 | 1 | 7 | 12 | |
| TCGA | ERAP2 | 64167 | 3 | 43 | 50 |
Total number of gains: 20; Total number of losses: 159; Total Number of normals: 309.
Somatic mutations of ERAP2:
Generating mutation plots.
Highly correlated genes for ERAP2:
Showing top 20/81 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ERAP2 | PGM2 | 0.75677 | 3 | 0 | 3 |
| ERAP2 | MPHOSPH6 | 0.730967 | 3 | 0 | 3 |
| ERAP2 | HPRT1 | 0.730095 | 3 | 0 | 3 |
| ERAP2 | CD2AP | 0.682337 | 3 | 0 | 3 |
| ERAP2 | GALNT3 | 0.665561 | 3 | 0 | 3 |
| ERAP2 | NMT1 | 0.662469 | 3 | 0 | 3 |
| ERAP2 | STYXL1 | 0.658838 | 3 | 0 | 3 |
| ERAP2 | CCNB1 | 0.65427 | 3 | 0 | 3 |
| ERAP2 | C1QBP | 0.652337 | 3 | 0 | 3 |
| ERAP2 | HDAC1 | 0.648374 | 3 | 0 | 3 |
| ERAP2 | UBA2 | 0.63981 | 3 | 0 | 3 |
| ERAP2 | STAM | 0.639583 | 3 | 0 | 3 |
| ERAP2 | DCAF13 | 0.631903 | 3 | 0 | 3 |
| ERAP2 | MPP6 | 0.631162 | 3 | 0 | 3 |
| ERAP2 | ACP1 | 0.626947 | 3 | 0 | 3 |
| ERAP2 | TMEM123 | 0.626036 | 3 | 0 | 3 |
| ERAP2 | HSD17B4 | 0.625961 | 3 | 0 | 3 |
| ERAP2 | UEVLD | 0.624821 | 3 | 0 | 3 |
| ERAP2 | SLC10A7 | 0.624758 | 4 | 0 | 3 |
| ERAP2 | PRIM1 | 0.623971 | 3 | 0 | 3 |
For details and further investigation, click here
