| Full name: endogenous retrovirus group 3 member 1, envelope | Alias Symbol: H-PLK|HERV-R|ERV-R|envR | ||
| Type: protein-coding gene | Cytoband: 7q11.21 | ||
| Entrez ID: 2086 | HGNC ID: HGNC:3454 | Ensembl Gene: ENSG00000213462 | OMIM ID: 131170 |
| Drug and gene relationship at DGIdb | |||
Expression of ERV3-1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ERV3-1 | 2086 | 1562777_at | -0.0012 | 0.9982 | |
| GSE26886 | ERV3-1 | 2086 | 1562777_at | -0.0881 | 0.6416 | |
| GSE45670 | ERV3-1 | 2086 | 1562777_at | 0.2142 | 0.2489 | |
| GSE53622 | ERV3-1 | 2086 | 46920 | 0.1548 | 0.3539 | |
| GSE53624 | ERV3-1 | 2086 | 46920 | -0.7837 | 0.0000 | |
| GSE63941 | ERV3-1 | 2086 | 1562777_at | 0.4057 | 0.2186 | |
| GSE77861 | ERV3-1 | 2086 | 1562777_at | -0.0954 | 0.3909 | |
| GSE97050 | ERV3-1 | 2086 | A_33_P3228355 | 0.5729 | 0.2582 | |
| SRP007169 | ERV3-1 | 2086 | RNAseq | -2.2455 | 0.0000 | |
| SRP008496 | ERV3-1 | 2086 | RNAseq | -1.0539 | 0.0376 | |
| SRP064894 | ERV3-1 | 2086 | RNAseq | -0.8724 | 0.0096 | |
| SRP133303 | ERV3-1 | 2086 | RNAseq | -0.4112 | 0.0502 | |
| SRP159526 | ERV3-1 | 2086 | RNAseq | -0.7451 | 0.1664 | |
| SRP193095 | ERV3-1 | 2086 | RNAseq | -0.3298 | 0.0792 | |
| SRP219564 | ERV3-1 | 2086 | RNAseq | -0.8565 | 0.1806 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by ERV3-1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of ERV3-1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ERV3-1 | 2086 | 11 | 2 | 17 | |
| GSE20123 | ERV3-1 | 2086 | 10 | 2 | 18 | |
| GSE43470 | ERV3-1 | 2086 | 2 | 1 | 40 | |
| GSE46452 | ERV3-1 | 2086 | 13 | 0 | 46 | |
| GSE47630 | ERV3-1 | 2086 | 7 | 1 | 32 | |
| GSE54993 | ERV3-1 | 2086 | 2 | 7 | 61 | |
| GSE54994 | ERV3-1 | 2086 | 12 | 4 | 37 | |
| GSE60625 | ERV3-1 | 2086 | 0 | 0 | 11 | |
| GSE74703 | ERV3-1 | 2086 | 2 | 1 | 33 | |
| GSE74704 | ERV3-1 | 2086 | 5 | 1 | 14 |
Total number of gains: 64; Total number of losses: 19; Total Number of normals: 309.
Somatic mutations of ERV3-1:
Generating mutation plots.
Highly correlated genes for ERV3-1:
Showing top 20/28 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ERV3-1 | LCE3D | 0.681957 | 3 | 0 | 3 |
| ERV3-1 | GFOD2 | 0.615438 | 5 | 0 | 3 |
| ERV3-1 | DSG1 | 0.607453 | 3 | 0 | 3 |
| ERV3-1 | ONECUT3 | 0.60252 | 3 | 0 | 3 |
| ERV3-1 | PANK2 | 0.597008 | 5 | 0 | 3 |
| ERV3-1 | OSBPL2 | 0.595192 | 4 | 0 | 3 |
| ERV3-1 | ATG9B | 0.566377 | 4 | 0 | 3 |
| ERV3-1 | PKP3 | 0.566277 | 4 | 0 | 3 |
| ERV3-1 | DAPP1 | 0.564612 | 4 | 0 | 3 |
| ERV3-1 | SLC11A2 | 0.560023 | 4 | 0 | 3 |
| ERV3-1 | ANKRD22 | 0.552594 | 5 | 0 | 4 |
| ERV3-1 | STRN | 0.542022 | 4 | 0 | 3 |
| ERV3-1 | ELOVL4 | 0.538854 | 4 | 0 | 3 |
| ERV3-1 | HMGCR | 0.534297 | 5 | 0 | 3 |
| ERV3-1 | LRRC37A3 | 0.533206 | 3 | 0 | 3 |
| ERV3-1 | MREG | 0.531463 | 6 | 0 | 4 |
| ERV3-1 | ARG1 | 0.530418 | 6 | 0 | 3 |
| ERV3-1 | CES4A | 0.529363 | 4 | 0 | 3 |
| ERV3-1 | DTX2 | 0.524418 | 5 | 0 | 4 |
| ERV3-1 | LYPLA1 | 0.520806 | 4 | 0 | 3 |
For details and further investigation, click here
