F2R

 

Full name: coagulation factor II thrombin receptor Alias Symbol: TR|CF2R|PAR1|PAR-1
Type: protein-coding gene Cytoband: 5q13.3
Entrez ID: 2149 HGNC ID: HGNC:3537 Ensembl Gene: ENSG00000181104 OMIM ID: 187930
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

F2R involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04024cAMP signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04610Complement and coagulation cascades
hsa04611Platelet activation
hsa04810Regulation of actin cytoskeleton

 

Expression of F2R:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 F2R 2149 203989_x_at 0.2458 0.8029
GSE20347 F2R 2149 203989_x_at 1.1732 0.0003
GSE23400 F2R 2149 203989_x_at 0.5471 0.0000
GSE26886 F2R 2149 1569642_at 0.5573 0.0032
GSE29001 F2R 2149 203989_x_at 0.8781 0.0195
GSE38129 F2R 2149 203989_x_at 1.0942 0.0000
GSE45670 F2R 2149 203989_x_at 0.4154 0.3416
GSE53622 F2R 2149 44380 1.2440 0.0000
GSE53624 F2R 2149 44380 1.3869 0.0000
GSE63941 F2R 2149 203989_x_at -4.3973 0.0006
GSE77861 F2R 2149 1569642_at 0.0870 0.5564
GSE97050 F2R 2149 A_33_P3212274 0.3614 0.2998
SRP007169 F2R 2149 RNAseq 2.1472 0.0000
SRP008496 F2R 2149 RNAseq 2.5267 0.0000
SRP064894 F2R 2149 RNAseq 0.9198 0.0059
SRP133303 F2R 2149 RNAseq 1.0664 0.0035
SRP159526 F2R 2149 RNAseq 1.7089 0.0000
SRP193095 F2R 2149 RNAseq 1.5059 0.0000
SRP219564 F2R 2149 RNAseq 1.4416 0.0033
TCGA F2R 2149 RNAseq 0.2580 0.0089

Upregulated datasets: 10; Downregulated datasets: 1.  

 

Survival by F2R expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of F2R:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 F2R 2149 1 13 16
GSE20123 F2R 2149 1 13 16
GSE43470 F2R 2149 1 13 29
GSE46452 F2R 2149 0 28 31
GSE47630 F2R 2149 1 19 20
GSE54993 F2R 2149 8 1 61
GSE54994 F2R 2149 1 19 33
GSE60625 F2R 2149 0 0 11
GSE74703 F2R 2149 1 9 26
GSE74704 F2R 2149 1 6 13
TCGA F2R 2149 5 49 42

Total number of gains: 20; Total number of losses: 170; Total Number of normals: 298.  

 

Somatic mutations of F2R:

 

Generating mutation plots.

 

Highly correlated genes for F2R:

 

Showing top 20/276 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
F2RCDH110.70930711010
F2RNID20.69291909
F2RCSGALNACT20.6903711010
F2RDACT10.675116909
F2RCOL3A10.66279811010
F2RFAP0.660579908
F2RGPX80.65757605
F2RCOL1A20.6566811109
F2RPAG10.654472707
F2RCOL6A30.65265212010
F2RPLXNC10.651094909
F2RCOL5A20.64978612011
F2RZNF2810.64929910010
F2RCHSY30.646371707
F2RRCN30.645378706
F2ROLFML2B0.64422311010
F2RGREM10.64306710010
F2RKCNQ1OT10.641739303
F2RCOL5A10.6414261008
F2RCHPF20.6408707

For details and further investigation, click here