| Full name: farnesyl-diphosphate farnesyltransferase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8p23.1 | ||
| Entrez ID: 2222 | HGNC ID: HGNC:3629 | Ensembl Gene: ENSG00000079459 | OMIM ID: 184420 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of FDFT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FDFT1 | 2222 | 208647_at | 0.2054 | 0.6303 | |
| GSE20347 | FDFT1 | 2222 | 208647_at | 0.2740 | 0.0829 | |
| GSE23400 | FDFT1 | 2222 | 208647_at | 0.0010 | 0.9949 | |
| GSE26886 | FDFT1 | 2222 | 208647_at | -0.0638 | 0.7845 | |
| GSE29001 | FDFT1 | 2222 | 208647_at | -0.2233 | 0.5217 | |
| GSE38129 | FDFT1 | 2222 | 208647_at | 0.1643 | 0.2973 | |
| GSE45670 | FDFT1 | 2222 | 208647_at | 0.0730 | 0.7726 | |
| GSE53622 | FDFT1 | 2222 | 25418 | -0.3161 | 0.0007 | |
| GSE53624 | FDFT1 | 2222 | 25418 | -0.3153 | 0.0001 | |
| GSE63941 | FDFT1 | 2222 | 208647_at | 0.1808 | 0.7540 | |
| GSE77861 | FDFT1 | 2222 | 210950_s_at | 0.0323 | 0.9194 | |
| GSE97050 | FDFT1 | 2222 | A_23_P71319 | -0.4050 | 0.1782 | |
| SRP007169 | FDFT1 | 2222 | RNAseq | -0.1232 | 0.6700 | |
| SRP008496 | FDFT1 | 2222 | RNAseq | -0.6470 | 0.0126 | |
| SRP064894 | FDFT1 | 2222 | RNAseq | -0.6430 | 0.0036 | |
| SRP133303 | FDFT1 | 2222 | RNAseq | -0.5152 | 0.0523 | |
| SRP159526 | FDFT1 | 2222 | RNAseq | 0.1233 | 0.6980 | |
| SRP193095 | FDFT1 | 2222 | RNAseq | -0.4348 | 0.0068 | |
| SRP219564 | FDFT1 | 2222 | RNAseq | -0.7233 | 0.1275 | |
| TCGA | FDFT1 | 2222 | RNAseq | 0.0264 | 0.6978 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FDFT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FDFT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FDFT1 | 2222 | 4 | 10 | 16 | |
| GSE20123 | FDFT1 | 2222 | 4 | 10 | 16 | |
| GSE43470 | FDFT1 | 2222 | 4 | 9 | 30 | |
| GSE46452 | FDFT1 | 2222 | 12 | 14 | 33 | |
| GSE47630 | FDFT1 | 2222 | 10 | 7 | 23 | |
| GSE54993 | FDFT1 | 2222 | 3 | 14 | 53 | |
| GSE54994 | FDFT1 | 2222 | 8 | 19 | 26 | |
| GSE60625 | FDFT1 | 2222 | 3 | 0 | 8 | |
| GSE74703 | FDFT1 | 2222 | 4 | 7 | 25 | |
| GSE74704 | FDFT1 | 2222 | 3 | 7 | 10 | |
| TCGA | FDFT1 | 2222 | 14 | 39 | 43 |
Total number of gains: 69; Total number of losses: 136; Total Number of normals: 283.
Somatic mutations of FDFT1:
Generating mutation plots.
Highly correlated genes for FDFT1:
Showing top 20/21 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FDFT1 | TMEFF2 | 0.604501 | 3 | 0 | 3 |
| FDFT1 | TMX1 | 0.603364 | 3 | 0 | 3 |
| FDFT1 | FARSB | 0.583407 | 3 | 0 | 3 |
| FDFT1 | ACAT2 | 0.574435 | 5 | 0 | 4 |
| FDFT1 | NOP10 | 0.564164 | 4 | 0 | 3 |
| FDFT1 | CNOT7 | 0.554638 | 11 | 0 | 9 |
| FDFT1 | ZWILCH | 0.549909 | 5 | 0 | 4 |
| FDFT1 | DBI | 0.547839 | 6 | 0 | 5 |
| FDFT1 | WRN | 0.529375 | 5 | 0 | 3 |
| FDFT1 | PBK | 0.528808 | 5 | 0 | 4 |
| FDFT1 | MMAB | 0.528653 | 5 | 0 | 3 |
| FDFT1 | GPC1 | 0.528339 | 4 | 0 | 3 |
| FDFT1 | HMGCS1 | 0.524563 | 9 | 0 | 4 |
| FDFT1 | ERI1 | 0.518097 | 5 | 0 | 3 |
| FDFT1 | SEC22A | 0.514208 | 5 | 0 | 3 |
| FDFT1 | BZW2 | 0.513044 | 6 | 0 | 3 |
| FDFT1 | ERI2 | 0.50984 | 6 | 0 | 3 |
| FDFT1 | SPRR1B | 0.50983 | 4 | 0 | 3 |
| FDFT1 | REEP4 | 0.50816 | 9 | 0 | 3 |
| FDFT1 | CLP1 | 0.506998 | 6 | 0 | 3 |
For details and further investigation, click here
