FZD10

 

Full name: frizzled class receptor 10 Alias Symbol: CD350
Type: protein-coding gene Cytoband: 12q24.33
Entrez ID: 11211 HGNC ID: HGNC:4039 Ensembl Gene: ENSG00000111432 OMIM ID: 606147
Drug and gene relationship at DGIdb

 

FZD10 involved pathways:

KEGG pathway Description View
hsa04150mTOR signaling pathway
hsa04310Wnt signaling pathway
hsa04390Hippo signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04916Melanogenesis
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05217Basal cell carcinoma

 

Expression of FZD10:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FZD10 11211 219764_at -1.5285 0.1840
GSE20347 FZD10 11211 219764_at -0.9099 0.0400
GSE23400 FZD10 11211 219764_at -0.4651 0.0342
GSE26886 FZD10 11211 219764_at 0.2646 0.7164
GSE29001 FZD10 11211 219764_at -0.9568 0.0711
GSE38129 FZD10 11211 219764_at 0.0519 0.9407
GSE45670 FZD10 11211 219764_at -0.2327 0.6392
GSE53622 FZD10 11211 31246 -0.5953 0.0133
GSE53624 FZD10 11211 31246 -1.1036 0.0000
GSE63941 FZD10 11211 219764_at 0.9986 0.6236
GSE77861 FZD10 11211 219764_at 0.6795 0.1579
GSE97050 FZD10 11211 A_23_P203972 0.1075 0.7875
SRP007169 FZD10 11211 RNAseq -1.5742 0.0000
SRP008496 FZD10 11211 RNAseq -0.8014 0.0858
SRP064894 FZD10 11211 RNAseq -1.6347 0.0001
SRP133303 FZD10 11211 RNAseq -0.3637 0.1980
SRP159526 FZD10 11211 RNAseq -0.4513 0.3809
SRP219564 FZD10 11211 RNAseq 0.7942 0.4460
TCGA FZD10 11211 RNAseq 1.3039 0.0000

Upregulated datasets: 1; Downregulated datasets: 3.  

 

Survival by FZD10 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FZD10:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FZD10 11211 4 4 22
GSE20123 FZD10 11211 4 4 22
GSE43470 FZD10 11211 2 2 39
GSE46452 FZD10 11211 8 2 49
GSE47630 FZD10 11211 9 3 28
GSE54993 FZD10 11211 0 5 65
GSE54994 FZD10 11211 4 7 42
GSE60625 FZD10 11211 0 0 11
GSE74703 FZD10 11211 2 1 33
GSE74704 FZD10 11211 2 3 15
TCGA FZD10 11211 21 14 61

Total number of gains: 56; Total number of losses: 45; Total Number of normals: 387.  

 

Somatic mutations of FZD10:

 

Generating mutation plots.

 

Highly correlated genes for FZD10:

 

Showing top 20/206 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FZD10SH3RF20.71731303
FZD10SBSN0.69953303
FZD10FAM110C0.690755403
FZD10NSRP10.651616403
FZD10CLCA20.64848606
FZD10ELL20.642576303
FZD10GJB60.635119403
FZD10CD440.632862303
FZD10DSC30.631909605
FZD10CNFN0.629886403
FZD10GJB50.628893504
FZD10IDH10.628529504
FZD10TMPRSS11B0.628208404
FZD10BNIPL0.627178403
FZD10PTPMT10.624832303
FZD10PKP10.624756705
FZD10CERS30.623207403
FZD10CYP4F30.619542908
FZD10HS3ST60.61928403
FZD10BTBD110.612628504

For details and further investigation, click here