| Full name: galactosylceramidase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q31.3 | ||
| Entrez ID: 2581 | HGNC ID: HGNC:4115 | Ensembl Gene: ENSG00000054983 | OMIM ID: 606890 |
| Drug and gene relationship at DGIdb | |||
Expression of GALC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GALC | 2581 | 204417_at | 0.3964 | 0.5621 | |
| GSE20347 | GALC | 2581 | 204417_at | 0.2455 | 0.5048 | |
| GSE23400 | GALC | 2581 | 204417_at | 0.6487 | 0.0000 | |
| GSE26886 | GALC | 2581 | 204417_at | 0.9254 | 0.1214 | |
| GSE29001 | GALC | 2581 | 204417_at | 0.6088 | 0.1389 | |
| GSE38129 | GALC | 2581 | 204417_at | 0.2089 | 0.5323 | |
| GSE45670 | GALC | 2581 | 204417_at | -0.1284 | 0.7131 | |
| GSE53622 | GALC | 2581 | 100630 | 0.5085 | 0.0000 | |
| GSE53624 | GALC | 2581 | 100630 | 0.6661 | 0.0000 | |
| GSE63941 | GALC | 2581 | 204417_at | -3.4348 | 0.0708 | |
| GSE77861 | GALC | 2581 | 204417_at | 0.4121 | 0.5587 | |
| GSE97050 | GALC | 2581 | A_23_P25964 | 0.5026 | 0.1992 | |
| SRP007169 | GALC | 2581 | RNAseq | 1.2287 | 0.0599 | |
| SRP008496 | GALC | 2581 | RNAseq | 1.3991 | 0.0043 | |
| SRP064894 | GALC | 2581 | RNAseq | 0.8791 | 0.0000 | |
| SRP133303 | GALC | 2581 | RNAseq | 0.8112 | 0.0022 | |
| SRP159526 | GALC | 2581 | RNAseq | 0.7246 | 0.0415 | |
| SRP193095 | GALC | 2581 | RNAseq | 0.0224 | 0.9422 | |
| SRP219564 | GALC | 2581 | RNAseq | 0.7204 | 0.1551 | |
| TCGA | GALC | 2581 | RNAseq | -0.2389 | 0.0428 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GALC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GALC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GALC | 2581 | 7 | 4 | 19 | |
| GSE20123 | GALC | 2581 | 7 | 4 | 19 | |
| GSE43470 | GALC | 2581 | 8 | 3 | 32 | |
| GSE46452 | GALC | 2581 | 16 | 3 | 40 | |
| GSE47630 | GALC | 2581 | 11 | 8 | 21 | |
| GSE54993 | GALC | 2581 | 3 | 8 | 59 | |
| GSE54994 | GALC | 2581 | 19 | 4 | 30 | |
| GSE60625 | GALC | 2581 | 0 | 2 | 9 | |
| GSE74703 | GALC | 2581 | 6 | 3 | 27 | |
| GSE74704 | GALC | 2581 | 4 | 4 | 12 | |
| TCGA | GALC | 2581 | 31 | 21 | 44 |
Total number of gains: 112; Total number of losses: 64; Total Number of normals: 312.
Somatic mutations of GALC:
Generating mutation plots.
Highly correlated genes for GALC:
Showing top 20/392 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GALC | RAE1 | 0.719474 | 3 | 0 | 3 |
| GALC | C1orf50 | 0.703502 | 3 | 0 | 3 |
| GALC | MR1 | 0.694942 | 3 | 0 | 3 |
| GALC | C7orf50 | 0.684418 | 3 | 0 | 3 |
| GALC | CENPQ | 0.646103 | 4 | 0 | 3 |
| GALC | NUDT14 | 0.642611 | 3 | 0 | 3 |
| GALC | VPS13B | 0.638967 | 3 | 0 | 3 |
| GALC | AKT1 | 0.633955 | 4 | 0 | 4 |
| GALC | AFAP1L2 | 0.633443 | 3 | 0 | 3 |
| GALC | RPS21 | 0.632272 | 4 | 0 | 3 |
| GALC | LRRC34 | 0.622214 | 3 | 0 | 3 |
| GALC | PEAR1 | 0.622186 | 3 | 0 | 3 |
| GALC | CLASP1 | 0.621048 | 3 | 0 | 3 |
| GALC | PSMA7 | 0.618591 | 4 | 0 | 3 |
| GALC | TTC8 | 0.617443 | 6 | 0 | 5 |
| GALC | EFCAB7 | 0.612089 | 4 | 0 | 3 |
| GALC | TIA1 | 0.609183 | 4 | 0 | 3 |
| GALC | PXMP4 | 0.608723 | 3 | 0 | 3 |
| GALC | NEK6 | 0.60799 | 4 | 0 | 3 |
| GALC | RAD17 | 0.60732 | 3 | 0 | 3 |
For details and further investigation, click here
