HNRNPK

 

Full name: heterogeneous nuclear ribonucleoprotein K Alias Symbol: CSBP|TUNP
Type: protein-coding gene Cytoband: 9q21.32
Entrez ID: 3190 HGNC ID: HGNC:5044 Ensembl Gene: ENSG00000165119 OMIM ID: 600712
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of HNRNPK:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 HNRNPK 3190 200775_s_at 0.2209 0.2320
GSE20347 HNRNPK 3190 200775_s_at 0.3842 0.0000
GSE23400 HNRNPK 3190 200775_s_at 0.4343 0.0000
GSE26886 HNRNPK 3190 200775_s_at -0.4167 0.0048
GSE29001 HNRNPK 3190 200775_s_at 0.1652 0.5885
GSE38129 HNRNPK 3190 200775_s_at 0.4092 0.0000
GSE45670 HNRNPK 3190 200775_s_at 0.2006 0.0033
GSE53622 HNRNPK 3190 590 0.0945 0.0223
GSE53624 HNRNPK 3190 590 0.4305 0.0000
GSE63941 HNRNPK 3190 200775_s_at 0.4129 0.0002
GSE77861 HNRNPK 3190 200775_s_at 0.2940 0.0582
GSE97050 HNRNPK 3190 A_24_P389517 0.2685 0.2942
SRP007169 HNRNPK 3190 RNAseq 0.6849 0.0354
SRP008496 HNRNPK 3190 RNAseq 0.6834 0.0005
SRP064894 HNRNPK 3190 RNAseq 0.1530 0.2761
SRP133303 HNRNPK 3190 RNAseq 0.2785 0.0035
SRP159526 HNRNPK 3190 RNAseq 0.1470 0.3400
SRP193095 HNRNPK 3190 RNAseq -0.0288 0.7388
SRP219564 HNRNPK 3190 RNAseq 0.0172 0.9199
TCGA HNRNPK 3190 RNAseq 0.0678 0.0718

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by HNRNPK expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of HNRNPK:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 HNRNPK 3190 5 10 15
GSE20123 HNRNPK 3190 5 10 15
GSE43470 HNRNPK 3190 6 3 34
GSE46452 HNRNPK 3190 6 14 39
GSE47630 HNRNPK 3190 1 18 21
GSE54993 HNRNPK 3190 4 2 64
GSE54994 HNRNPK 3190 6 12 35
GSE60625 HNRNPK 3190 0 0 11
GSE74703 HNRNPK 3190 5 3 28
GSE74704 HNRNPK 3190 3 7 10
TCGA HNRNPK 3190 20 28 48

Total number of gains: 61; Total number of losses: 107; Total Number of normals: 320.  

 

Somatic mutations of HNRNPK:

 

Generating mutation plots.

 

Highly correlated genes for HNRNPK:

 

Showing top 20/329 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
HNRNPKFEN10.785721707
HNRNPKALDH16A10.728297303
HNRNPKLSAMP-AS10.718026303
HNRNPKRUVBL10.7038610010
HNRNPKKIF18B0.699437807
HNRNPKNEK20.694191807
HNRNPKDHX90.6857908
HNRNPKCCT30.682559908
HNRNPKCDC200.6810161009
HNRNPKMCM50.680843907
HNRNPKGEN10.676886303
HNRNPKCHEK20.675976808
HNRNPKNUP2100.675899505
HNRNPKRBM420.66959403
HNRNPKUBE2C0.669563908
HNRNPKTPX20.6691510010
HNRNPKTIMELESS0.665119807
HNRNPKCDC70.661724808
HNRNPKBUB1B0.660496907
HNRNPKKIF2C0.659951908

For details and further investigation, click here