| Full name: HPS6 biogenesis of lysosomal organelles complex 2 subunit 3 | Alias Symbol: FLJ22501|BLOC2S3 | ||
| Type: protein-coding gene | Cytoband: 10q24.32 | ||
| Entrez ID: 79803 | HGNC ID: HGNC:18817 | Ensembl Gene: ENSG00000166189 | OMIM ID: 607522 |
| Drug and gene relationship at DGIdb | |||
Expression of HPS6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HPS6 | 79803 | 219052_at | 0.2882 | 0.5400 | |
| GSE20347 | HPS6 | 79803 | 219052_at | -0.2900 | 0.0018 | |
| GSE23400 | HPS6 | 79803 | 219052_at | 0.0444 | 0.3643 | |
| GSE26886 | HPS6 | 79803 | 219052_at | -0.2252 | 0.0845 | |
| GSE29001 | HPS6 | 79803 | 219052_at | -0.0284 | 0.8973 | |
| GSE38129 | HPS6 | 79803 | 219052_at | -0.1383 | 0.2003 | |
| GSE45670 | HPS6 | 79803 | 219052_at | 0.1488 | 0.1846 | |
| GSE53622 | HPS6 | 79803 | 142637 | -0.0193 | 0.7640 | |
| GSE53624 | HPS6 | 79803 | 142637 | -0.1345 | 0.0132 | |
| GSE63941 | HPS6 | 79803 | 219052_at | -0.2960 | 0.3091 | |
| GSE77861 | HPS6 | 79803 | 219052_at | 0.0684 | 0.6553 | |
| GSE97050 | HPS6 | 79803 | A_23_P115683 | 0.2754 | 0.3721 | |
| SRP007169 | HPS6 | 79803 | RNAseq | -0.7654 | 0.0523 | |
| SRP008496 | HPS6 | 79803 | RNAseq | -0.4640 | 0.0762 | |
| SRP064894 | HPS6 | 79803 | RNAseq | 0.1005 | 0.6581 | |
| SRP133303 | HPS6 | 79803 | RNAseq | 0.0836 | 0.6166 | |
| SRP159526 | HPS6 | 79803 | RNAseq | -0.3695 | 0.3228 | |
| SRP193095 | HPS6 | 79803 | RNAseq | -0.0199 | 0.8545 | |
| SRP219564 | HPS6 | 79803 | RNAseq | -0.1906 | 0.6076 | |
| TCGA | HPS6 | 79803 | RNAseq | -0.1427 | 0.0105 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HPS6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HPS6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HPS6 | 79803 | 2 | 9 | 19 | |
| GSE20123 | HPS6 | 79803 | 2 | 8 | 20 | |
| GSE43470 | HPS6 | 79803 | 0 | 8 | 35 | |
| GSE46452 | HPS6 | 79803 | 0 | 11 | 48 | |
| GSE47630 | HPS6 | 79803 | 2 | 14 | 24 | |
| GSE54993 | HPS6 | 79803 | 8 | 0 | 62 | |
| GSE54994 | HPS6 | 79803 | 1 | 12 | 40 | |
| GSE60625 | HPS6 | 79803 | 0 | 0 | 11 | |
| GSE74703 | HPS6 | 79803 | 0 | 5 | 31 | |
| GSE74704 | HPS6 | 79803 | 1 | 4 | 15 | |
| TCGA | HPS6 | 79803 | 5 | 29 | 62 |
Total number of gains: 21; Total number of losses: 100; Total Number of normals: 367.
Somatic mutations of HPS6:
Generating mutation plots.
Highly correlated genes for HPS6:
Showing top 20/124 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HPS6 | PAFAH1B3 | 0.688688 | 3 | 0 | 3 |
| HPS6 | MPV17L2 | 0.642435 | 3 | 0 | 3 |
| HPS6 | TMC7 | 0.624804 | 3 | 0 | 3 |
| HPS6 | SRD5A1 | 0.622125 | 4 | 0 | 3 |
| HPS6 | FDXR | 0.619925 | 6 | 0 | 4 |
| HPS6 | SH3PXD2A | 0.617048 | 4 | 0 | 3 |
| HPS6 | RAB5B | 0.612787 | 4 | 0 | 4 |
| HPS6 | PFKL | 0.609207 | 5 | 0 | 5 |
| HPS6 | GTF3C1 | 0.606724 | 4 | 0 | 3 |
| HPS6 | STK11 | 0.605515 | 5 | 0 | 4 |
| HPS6 | CHCHD1 | 0.601197 | 4 | 0 | 3 |
| HPS6 | SZT2 | 0.600658 | 3 | 0 | 3 |
| HPS6 | REEP4 | 0.598654 | 4 | 0 | 3 |
| HPS6 | TM9SF3 | 0.59757 | 4 | 0 | 3 |
| HPS6 | RABEP2 | 0.597034 | 5 | 0 | 4 |
| HPS6 | SLC22A23 | 0.594325 | 4 | 0 | 3 |
| HPS6 | ADAM21 | 0.593558 | 3 | 0 | 3 |
| HPS6 | LETM1 | 0.589759 | 4 | 0 | 3 |
| HPS6 | CES2 | 0.587316 | 4 | 0 | 3 |
| HPS6 | NPLOC4 | 0.586959 | 3 | 0 | 3 |
For details and further investigation, click here
