| Full name: HtrA serine peptidase 2 | Alias Symbol: OMI|PARK13 | ||
| Type: protein-coding gene | Cytoband: 2p13.1 | ||
| Entrez ID: 27429 | HGNC ID: HGNC:14348 | Ensembl Gene: ENSG00000115317 | OMIM ID: 606441 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
HTRA2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04210 | Apoptosis | |
| hsa05012 | Parkinson's disease |
Expression of HTRA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HTRA2 | 27429 | 203089_s_at | 0.4596 | 0.1168 | |
| GSE20347 | HTRA2 | 27429 | 203089_s_at | 0.4440 | 0.0021 | |
| GSE23400 | HTRA2 | 27429 | 203089_s_at | 0.3962 | 0.0000 | |
| GSE26886 | HTRA2 | 27429 | 203089_s_at | 0.4889 | 0.0145 | |
| GSE29001 | HTRA2 | 27429 | 203089_s_at | 0.3622 | 0.1876 | |
| GSE38129 | HTRA2 | 27429 | 203089_s_at | 0.3442 | 0.0111 | |
| GSE45670 | HTRA2 | 27429 | 203089_s_at | 0.1926 | 0.2749 | |
| GSE53622 | HTRA2 | 27429 | 20388 | 0.6016 | 0.0000 | |
| GSE53624 | HTRA2 | 27429 | 20388 | 0.5855 | 0.0000 | |
| GSE63941 | HTRA2 | 27429 | 203089_s_at | 0.2447 | 0.4258 | |
| GSE77861 | HTRA2 | 27429 | 203089_s_at | 0.6225 | 0.0189 | |
| GSE97050 | HTRA2 | 27429 | A_24_P336957 | 0.2463 | 0.2842 | |
| SRP007169 | HTRA2 | 27429 | RNAseq | 0.7639 | 0.0334 | |
| SRP008496 | HTRA2 | 27429 | RNAseq | 0.8956 | 0.0002 | |
| SRP064894 | HTRA2 | 27429 | RNAseq | 0.7668 | 0.0028 | |
| SRP133303 | HTRA2 | 27429 | RNAseq | 0.2228 | 0.1696 | |
| SRP159526 | HTRA2 | 27429 | RNAseq | 0.8151 | 0.0193 | |
| SRP193095 | HTRA2 | 27429 | RNAseq | 0.2655 | 0.0164 | |
| SRP219564 | HTRA2 | 27429 | RNAseq | 0.2688 | 0.3345 | |
| TCGA | HTRA2 | 27429 | RNAseq | 0.1342 | 0.0185 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HTRA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HTRA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HTRA2 | 27429 | 9 | 2 | 19 | |
| GSE20123 | HTRA2 | 27429 | 10 | 2 | 18 | |
| GSE43470 | HTRA2 | 27429 | 4 | 0 | 39 | |
| GSE46452 | HTRA2 | 27429 | 2 | 3 | 54 | |
| GSE47630 | HTRA2 | 27429 | 7 | 0 | 33 | |
| GSE54993 | HTRA2 | 27429 | 0 | 6 | 64 | |
| GSE54994 | HTRA2 | 27429 | 10 | 0 | 43 | |
| GSE60625 | HTRA2 | 27429 | 0 | 3 | 8 | |
| GSE74703 | HTRA2 | 27429 | 4 | 0 | 32 | |
| GSE74704 | HTRA2 | 27429 | 8 | 0 | 12 | |
| TCGA | HTRA2 | 27429 | 37 | 2 | 57 |
Total number of gains: 91; Total number of losses: 18; Total Number of normals: 379.
Somatic mutations of HTRA2:
Generating mutation plots.
Highly correlated genes for HTRA2:
Showing top 20/1998 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HTRA2 | SLC35B2 | 0.80991 | 3 | 0 | 3 |
| HTRA2 | RAB34 | 0.795654 | 3 | 0 | 3 |
| HTRA2 | PTGFRN | 0.736624 | 4 | 0 | 4 |
| HTRA2 | SNAP47 | 0.735421 | 3 | 0 | 3 |
| HTRA2 | PYCR2 | 0.73324 | 3 | 0 | 3 |
| HTRA2 | WDR54 | 0.726521 | 7 | 0 | 7 |
| HTRA2 | PLEKHA3 | 0.72583 | 3 | 0 | 3 |
| HTRA2 | DNAJC19 | 0.725196 | 3 | 0 | 3 |
| HTRA2 | BAK1 | 0.724453 | 3 | 0 | 3 |
| HTRA2 | NRIP1 | 0.723714 | 3 | 0 | 3 |
| HTRA2 | NF1 | 0.723262 | 3 | 0 | 3 |
| HTRA2 | PPIL1 | 0.713498 | 4 | 0 | 4 |
| HTRA2 | ATP6V1E2 | 0.712601 | 6 | 0 | 6 |
| HTRA2 | TSN | 0.712339 | 9 | 0 | 9 |
| HTRA2 | TMEM200A | 0.708667 | 3 | 0 | 3 |
| HTRA2 | BNIP1 | 0.706516 | 3 | 0 | 3 |
| HTRA2 | FAM89B | 0.703982 | 4 | 0 | 4 |
| HTRA2 | ELOF1 | 0.702617 | 4 | 0 | 4 |
| HTRA2 | VPS72 | 0.699637 | 9 | 0 | 9 |
| HTRA2 | AATF | 0.699562 | 11 | 0 | 11 |
For details and further investigation, click here
