| Full name: interferon lambda receptor 1 | Alias Symbol: CRF2/12|IFNLR|IL-28R1 | ||
| Type: protein-coding gene | Cytoband: 1p36.11 | ||
| Entrez ID: 163702 | HGNC ID: HGNC:18584 | Ensembl Gene: ENSG00000185436 | OMIM ID: 607404 |
| Drug and gene relationship at DGIdb | |||
IFNLR1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway |
Expression of IFNLR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IFNLR1 | 163702 | 244261_at | 0.8535 | 0.2245 | |
| GSE26886 | IFNLR1 | 163702 | 244261_at | 0.6691 | 0.0555 | |
| GSE45670 | IFNLR1 | 163702 | 244261_at | 0.5404 | 0.0051 | |
| GSE53622 | IFNLR1 | 163702 | 130208 | 0.8003 | 0.0000 | |
| GSE53624 | IFNLR1 | 163702 | 130208 | 0.0648 | 0.4094 | |
| GSE63941 | IFNLR1 | 163702 | 244261_at | 2.0650 | 0.0098 | |
| GSE77861 | IFNLR1 | 163702 | 1555499_a_at | -0.0695 | 0.5253 | |
| SRP007169 | IFNLR1 | 163702 | RNAseq | 0.1000 | 0.7920 | |
| SRP008496 | IFNLR1 | 163702 | RNAseq | -0.1011 | 0.6947 | |
| SRP064894 | IFNLR1 | 163702 | RNAseq | 0.3632 | 0.2323 | |
| SRP133303 | IFNLR1 | 163702 | RNAseq | 0.4982 | 0.0324 | |
| SRP159526 | IFNLR1 | 163702 | RNAseq | 0.3438 | 0.2586 | |
| SRP193095 | IFNLR1 | 163702 | RNAseq | 0.4149 | 0.0057 | |
| SRP219564 | IFNLR1 | 163702 | RNAseq | -0.2568 | 0.7201 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by IFNLR1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of IFNLR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IFNLR1 | 163702 | 0 | 5 | 25 | |
| GSE20123 | IFNLR1 | 163702 | 0 | 4 | 26 | |
| GSE43470 | IFNLR1 | 163702 | 2 | 6 | 35 | |
| GSE46452 | IFNLR1 | 163702 | 5 | 1 | 53 | |
| GSE47630 | IFNLR1 | 163702 | 8 | 3 | 29 | |
| GSE54993 | IFNLR1 | 163702 | 2 | 1 | 67 | |
| GSE54994 | IFNLR1 | 163702 | 11 | 4 | 38 | |
| GSE60625 | IFNLR1 | 163702 | 0 | 0 | 11 | |
| GSE74703 | IFNLR1 | 163702 | 1 | 4 | 31 | |
| GSE74704 | IFNLR1 | 163702 | 0 | 0 | 20 | |
| TCGA | IFNLR1 | 163702 | 10 | 23 | 63 |
Total number of gains: 39; Total number of losses: 51; Total Number of normals: 398.
Somatic mutations of IFNLR1:
Generating mutation plots.
Highly correlated genes for IFNLR1:
Showing top 20/169 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IFNLR1 | CLSPN | 0.713693 | 3 | 0 | 3 |
| IFNLR1 | WDHD1 | 0.688734 | 3 | 0 | 3 |
| IFNLR1 | IAH1 | 0.687527 | 3 | 0 | 3 |
| IFNLR1 | RNASEH2A | 0.672215 | 3 | 0 | 3 |
| IFNLR1 | POLE2 | 0.659607 | 3 | 0 | 3 |
| IFNLR1 | DSG2 | 0.657957 | 4 | 0 | 3 |
| IFNLR1 | RPS6KA1 | 0.654688 | 4 | 0 | 4 |
| IFNLR1 | RFC2 | 0.651558 | 3 | 0 | 3 |
| IFNLR1 | DONSON | 0.650214 | 3 | 0 | 3 |
| IFNLR1 | SSRP1 | 0.643489 | 3 | 0 | 3 |
| IFNLR1 | RAD51B | 0.641857 | 3 | 0 | 3 |
| IFNLR1 | POLD2 | 0.641616 | 4 | 0 | 3 |
| IFNLR1 | ANLN | 0.639283 | 3 | 0 | 3 |
| IFNLR1 | LRRC42 | 0.633832 | 3 | 0 | 3 |
| IFNLR1 | MTHFD1 | 0.632782 | 3 | 0 | 3 |
| IFNLR1 | IRF6 | 0.629991 | 5 | 0 | 4 |
| IFNLR1 | ITPR3 | 0.629873 | 5 | 0 | 5 |
| IFNLR1 | SMC6 | 0.628646 | 4 | 0 | 3 |
| IFNLR1 | OVOL2 | 0.627475 | 4 | 0 | 4 |
| IFNLR1 | EPCAM | 0.624834 | 4 | 0 | 3 |
For details and further investigation, click here
