POLD2

 

Full name: DNA polymerase delta 2, accessory subunit Alias Symbol: 
Type: protein-coding gene Cytoband: 7p13
Entrez ID: 5425 HGNC ID: HGNC:9176 Ensembl Gene: ENSG00000106628 OMIM ID: 600815
Drug and gene relationship at DGIdb

 

POLD2 involved pathways:

KEGG pathway Description View
hsa05166HTLV-I infection

 

Expression of POLD2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 POLD2 5425 201115_at 0.3699 0.2533
GSE20347 POLD2 5425 201115_at 0.4999 0.0034
GSE23400 POLD2 5425 201115_at 0.4632 0.0000
GSE26886 POLD2 5425 201115_at 0.2251 0.2204
GSE29001 POLD2 5425 201115_at 0.2502 0.3922
GSE38129 POLD2 5425 201115_at 0.6285 0.0000
GSE45670 POLD2 5425 201115_at 0.2718 0.0502
GSE53622 POLD2 5425 41339 0.4186 0.0000
GSE53624 POLD2 5425 41339 0.5692 0.0000
GSE63941 POLD2 5425 201115_at 1.9978 0.0007
GSE77861 POLD2 5425 201115_at 0.1797 0.3017
GSE97050 POLD2 5425 A_23_P71146 -0.0305 0.9036
SRP007169 POLD2 5425 RNAseq -0.5010 0.1007
SRP008496 POLD2 5425 RNAseq -0.2232 0.3197
SRP064894 POLD2 5425 RNAseq 0.5333 0.0634
SRP133303 POLD2 5425 RNAseq 0.2793 0.0889
SRP159526 POLD2 5425 RNAseq 0.7157 0.0099
SRP193095 POLD2 5425 RNAseq 0.1935 0.2585
SRP219564 POLD2 5425 RNAseq 0.2593 0.4472
TCGA POLD2 5425 RNAseq 0.2783 0.0000

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by POLD2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of POLD2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 POLD2 5425 14 0 16
GSE20123 POLD2 5425 13 0 17
GSE43470 POLD2 5425 4 0 39
GSE46452 POLD2 5425 11 1 47
GSE47630 POLD2 5425 8 1 31
GSE54993 POLD2 5425 0 8 62
GSE54994 POLD2 5425 17 3 33
GSE60625 POLD2 5425 0 0 11
GSE74703 POLD2 5425 4 0 32
GSE74704 POLD2 5425 7 0 13
TCGA POLD2 5425 51 7 38

Total number of gains: 129; Total number of losses: 20; Total Number of normals: 339.  

 

Somatic mutations of POLD2:

 

Generating mutation plots.

 

Highly correlated genes for POLD2:

 

Showing top 20/822 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
POLD2DDX560.69689713010
POLD2ERCC6L0.684595707
POLD2WDR740.674828909
POLD2FEN10.66281706
POLD2ZNF7860.659866303
POLD2SNRPB0.6566971009
POLD2DIAPH30.652268403
POLD2RNASEH2A0.64999510010
POLD2C1orf1120.649549807
POLD2CCNB10.64863810010
POLD2LSM50.6468641108
POLD2ZGRF10.644677303
POLD2MELK0.643549908
POLD2DLGAP50.6424281009
POLD2CKAP2L0.641891504
POLD2EIF2AK10.6417621009
POLD2IFNLR10.641616403
POLD2TIPIN0.640517807
POLD2POC1A0.640493605
POLD2MRPL420.64016606

For details and further investigation, click here