IGF1R

 

Full name: insulin like growth factor 1 receptor Alias Symbol: JTK13|CD221|IGFIR|MGC18216|IGFR
Type: protein-coding gene Cytoband: 15q26.3
Entrez ID: 3480 HGNC ID: HGNC:5465 Ensembl Gene: ENSG00000140443 OMIM ID: 147370
Drug and gene relationship at DGIdb
Screen Evidence:

 

IGF1R involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04066HIF-1 signaling pathway
hsa04068FoxO signaling pathway
hsa04114Oocyte meiosis
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04510Focal adhesion
hsa04520Adherens junction
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04730Long-term depression
hsa04913Ovarian steroidogenesis
hsa04914Progesterone-mediated oocyte maturation
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma

 

Expression of IGF1R:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IGF1R 3480 225330_at 0.5928 0.2475
GSE20347 IGF1R 3480 203628_at 0.8736 0.0003
GSE23400 IGF1R 3480 203627_at 0.6390 0.0000
GSE26886 IGF1R 3480 225330_at 1.9874 0.0000
GSE29001 IGF1R 3480 203628_at 0.7169 0.0024
GSE38129 IGF1R 3480 203628_at 0.9475 0.0001
GSE45670 IGF1R 3480 225330_at 0.2701 0.1831
GSE53622 IGF1R 3480 66923 0.5085 0.0003
GSE53624 IGF1R 3480 67947 0.7786 0.0000
GSE63941 IGF1R 3480 225330_at 0.7929 0.1313
GSE77861 IGF1R 3480 225330_at 0.9416 0.0127
GSE97050 IGF1R 3480 A_23_P417282 0.0115 0.9770
SRP007169 IGF1R 3480 RNAseq 1.8068 0.0000
SRP008496 IGF1R 3480 RNAseq 1.7211 0.0000
SRP064894 IGF1R 3480 RNAseq 0.3797 0.0927
SRP133303 IGF1R 3480 RNAseq 0.9176 0.0004
SRP159526 IGF1R 3480 RNAseq 0.9961 0.0094
SRP193095 IGF1R 3480 RNAseq 0.9655 0.0000
SRP219564 IGF1R 3480 RNAseq 0.3612 0.4134
TCGA IGF1R 3480 RNAseq 0.0153 0.8326

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by IGF1R expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IGF1R:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IGF1R 3480 7 1 22
GSE20123 IGF1R 3480 7 1 22
GSE43470 IGF1R 3480 7 5 31
GSE46452 IGF1R 3480 3 7 49
GSE47630 IGF1R 3480 9 10 21
GSE54993 IGF1R 3480 4 6 60
GSE54994 IGF1R 3480 9 7 37
GSE60625 IGF1R 3480 4 0 7
GSE74703 IGF1R 3480 6 4 26
GSE74704 IGF1R 3480 3 2 15
TCGA IGF1R 3480 18 13 65

Total number of gains: 77; Total number of losses: 56; Total Number of normals: 355.  

 

Somatic mutations of IGF1R:

 

Generating mutation plots.

 

Highly correlated genes for IGF1R:

 

Showing top 20/699 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IGF1RSDCCAG80.791354303
IGF1RSCYL10.759189303
IGF1RKNSTRN0.753628404
IGF1RTMEM2160.727642303
IGF1RUBE2T0.712141404
IGF1RNT5DC30.708986303
IGF1RMRPL470.696128404
IGF1RCDK60.683951706
IGF1RASXL20.67753504
IGF1RWDR720.669188504
IGF1RIGFBP40.665081404
IGF1RSNAI20.657659907
IGF1RGOLM10.655558504
IGF1RPLXNA10.6522631009
IGF1RNCOR20.651733605
IGF1RFANCI0.651083908
IGF1RSRRT0.650366707
IGF1RCENPF0.650201808
IGF1RCEP550.649312707
IGF1RPUS70.649284808

For details and further investigation, click here