| Full name: secretory leukocyte peptidase inhibitor | Alias Symbol: HUSI-I|ALK1|ALP|BLPI|HUSI|WAP4|WFDC4 | ||
| Type: protein-coding gene | Cytoband: 20q13.12 | ||
| Entrez ID: 6590 | HGNC ID: HGNC:11092 | Ensembl Gene: ENSG00000124107 | OMIM ID: 107285 |
| Drug and gene relationship at DGIdb | |||
Expression of SLPI:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLPI | 6590 | 203021_at | -1.1040 | 0.2909 | |
| GSE20347 | SLPI | 6590 | 203021_at | -2.4519 | 0.0000 | |
| GSE23400 | SLPI | 6590 | 203021_at | -1.6649 | 0.0000 | |
| GSE26886 | SLPI | 6590 | 203021_at | -2.9484 | 0.0000 | |
| GSE29001 | SLPI | 6590 | 203021_at | -2.0072 | 0.0066 | |
| GSE38129 | SLPI | 6590 | 203021_at | -1.7180 | 0.0009 | |
| GSE45670 | SLPI | 6590 | 203021_at | -0.1218 | 0.7240 | |
| GSE53622 | SLPI | 6590 | 23696 | -1.8040 | 0.0000 | |
| GSE53624 | SLPI | 6590 | 23696 | -2.2370 | 0.0000 | |
| GSE63941 | SLPI | 6590 | 203021_at | 4.4533 | 0.0084 | |
| GSE77861 | SLPI | 6590 | 203021_at | -1.1263 | 0.0903 | |
| GSE97050 | SLPI | 6590 | A_24_P190472 | 0.2338 | 0.8150 | |
| SRP007169 | SLPI | 6590 | RNAseq | -4.4590 | 0.0000 | |
| SRP008496 | SLPI | 6590 | RNAseq | -3.9027 | 0.0000 | |
| SRP064894 | SLPI | 6590 | RNAseq | -3.3623 | 0.0000 | |
| SRP133303 | SLPI | 6590 | RNAseq | -1.9936 | 0.0000 | |
| SRP159526 | SLPI | 6590 | RNAseq | -2.8537 | 0.0012 | |
| SRP193095 | SLPI | 6590 | RNAseq | -2.1789 | 0.0000 | |
| SRP219564 | SLPI | 6590 | RNAseq | -1.4182 | 0.1010 | |
| TCGA | SLPI | 6590 | RNAseq | 0.2124 | 0.2904 |
Upregulated datasets: 1; Downregulated datasets: 13.
Survival by SLPI expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLPI:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLPI | 6590 | 13 | 1 | 16 | |
| GSE20123 | SLPI | 6590 | 13 | 1 | 16 | |
| GSE43470 | SLPI | 6590 | 12 | 1 | 30 | |
| GSE46452 | SLPI | 6590 | 29 | 0 | 30 | |
| GSE47630 | SLPI | 6590 | 24 | 1 | 15 | |
| GSE54993 | SLPI | 6590 | 0 | 17 | 53 | |
| GSE54994 | SLPI | 6590 | 25 | 0 | 28 | |
| GSE60625 | SLPI | 6590 | 0 | 0 | 11 | |
| GSE74703 | SLPI | 6590 | 10 | 1 | 25 | |
| GSE74704 | SLPI | 6590 | 9 | 0 | 11 | |
| TCGA | SLPI | 6590 | 45 | 3 | 48 |
Total number of gains: 180; Total number of losses: 25; Total Number of normals: 283.
Somatic mutations of SLPI:
Generating mutation plots.
Highly correlated genes for SLPI:
Showing top 20/1122 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLPI | SERPINB1 | 0.780647 | 12 | 0 | 11 |
| SLPI | PGLYRP3 | 0.779141 | 4 | 0 | 4 |
| SLPI | ANXA1 | 0.774067 | 12 | 0 | 12 |
| SLPI | TGM1 | 0.773083 | 13 | 0 | 12 |
| SLPI | SH3RF2 | 0.762266 | 7 | 0 | 7 |
| SLPI | S100A9 | 0.761816 | 13 | 0 | 12 |
| SLPI | CRCT1 | 0.760453 | 12 | 0 | 12 |
| SLPI | IL1RN | 0.7599 | 13 | 0 | 13 |
| SLPI | GBP6 | 0.753594 | 3 | 0 | 3 |
| SLPI | MALL | 0.753589 | 12 | 0 | 11 |
| SLPI | SERPINB3 | 0.750945 | 11 | 0 | 10 |
| SLPI | SERPINB2 | 0.748565 | 12 | 0 | 12 |
| SLPI | CERS3 | 0.745601 | 6 | 0 | 6 |
| SLPI | CXCR2 | 0.745002 | 9 | 0 | 9 |
| SLPI | EPHA2 | 0.743812 | 12 | 0 | 12 |
| SLPI | MPZL2 | 0.743626 | 12 | 0 | 11 |
| SLPI | LYPD3 | 0.743344 | 12 | 0 | 11 |
| SLPI | CLIC3 | 0.742843 | 10 | 0 | 9 |
| SLPI | RAB27B | 0.740072 | 10 | 0 | 9 |
| SLPI | EPGN | 0.739132 | 3 | 0 | 3 |
For details and further investigation, click here
