| Full name: luteinizing hormone/choriogonadotropin receptor | Alias Symbol: LHR|LCGR|LGR2|ULG5 | ||
| Type: protein-coding gene | Cytoband: 2p16.3 | ||
| Entrez ID: 3973 | HGNC ID: HGNC:6585 | Ensembl Gene: ENSG00000138039 | OMIM ID: 152790 |
| Drug and gene relationship at DGIdb | |||
LHCGR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04913 | Ovarian steroidogenesis | |
| hsa04917 | Prolactin signaling pathway |
Expression of LHCGR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LHCGR | 3973 | 207240_s_at | -0.6485 | 0.5426 | |
| GSE20347 | LHCGR | 3973 | 207240_s_at | 0.0830 | 0.1491 | |
| GSE23400 | LHCGR | 3973 | 207240_s_at | -0.0558 | 0.1531 | |
| GSE26886 | LHCGR | 3973 | 207240_s_at | 0.0256 | 0.7623 | |
| GSE29001 | LHCGR | 3973 | 207240_s_at | 0.0640 | 0.6985 | |
| GSE38129 | LHCGR | 3973 | 207240_s_at | -0.0976 | 0.3743 | |
| GSE45670 | LHCGR | 3973 | 207240_s_at | -0.1237 | 0.0443 | |
| GSE53622 | LHCGR | 3973 | 27580 | -0.8865 | 0.0002 | |
| GSE53624 | LHCGR | 3973 | 27580 | -0.5226 | 0.0000 | |
| GSE63941 | LHCGR | 3973 | 207240_s_at | -1.1754 | 0.0487 | |
| GSE77861 | LHCGR | 3973 | 207240_s_at | -0.0689 | 0.3333 | |
| SRP133303 | LHCGR | 3973 | RNAseq | 0.0239 | 0.9663 | |
| TCGA | LHCGR | 3973 | RNAseq | -1.9524 | 0.0756 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by LHCGR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LHCGR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LHCGR | 3973 | 7 | 1 | 22 | |
| GSE20123 | LHCGR | 3973 | 6 | 1 | 23 | |
| GSE43470 | LHCGR | 3973 | 5 | 0 | 38 | |
| GSE46452 | LHCGR | 3973 | 1 | 4 | 54 | |
| GSE47630 | LHCGR | 3973 | 8 | 0 | 32 | |
| GSE54993 | LHCGR | 3973 | 0 | 5 | 65 | |
| GSE54994 | LHCGR | 3973 | 12 | 0 | 41 | |
| GSE60625 | LHCGR | 3973 | 0 | 3 | 8 | |
| GSE74703 | LHCGR | 3973 | 5 | 0 | 31 | |
| GSE74704 | LHCGR | 3973 | 7 | 1 | 12 | |
| TCGA | LHCGR | 3973 | 36 | 2 | 58 |
Total number of gains: 87; Total number of losses: 17; Total Number of normals: 384.
Somatic mutations of LHCGR:
Generating mutation plots.
Highly correlated genes for LHCGR:
Showing top 20/166 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LHCGR | NRK | 0.752804 | 3 | 0 | 3 |
| LHCGR | IQUB | 0.728749 | 3 | 0 | 3 |
| LHCGR | LINC00702 | 0.72132 | 3 | 0 | 3 |
| LHCGR | GNG8 | 0.679791 | 3 | 0 | 3 |
| LHCGR | EPHA7 | 0.669654 | 4 | 0 | 4 |
| LHCGR | GMPR | 0.655343 | 4 | 0 | 4 |
| LHCGR | VAT1L | 0.645956 | 3 | 0 | 3 |
| LHCGR | ABCC9 | 0.635892 | 5 | 0 | 3 |
| LHCGR | SLC8A1 | 0.635774 | 4 | 0 | 4 |
| LHCGR | ABCA9 | 0.633898 | 4 | 0 | 3 |
| LHCGR | ZNF660 | 0.632345 | 3 | 0 | 3 |
| LHCGR | IFNA10 | 0.629283 | 3 | 0 | 3 |
| LHCGR | PARD3B | 0.629148 | 4 | 0 | 4 |
| LHCGR | NPY | 0.625979 | 6 | 0 | 5 |
| LHCGR | FABP3 | 0.619453 | 6 | 0 | 3 |
| LHCGR | ARHGEF25 | 0.619214 | 4 | 0 | 3 |
| LHCGR | PARVA | 0.618887 | 4 | 0 | 3 |
| LHCGR | ATP6V1G2 | 0.618644 | 4 | 0 | 3 |
| LHCGR | RGMB | 0.613762 | 4 | 0 | 3 |
| LHCGR | PGR | 0.612019 | 4 | 0 | 3 |
For details and further investigation, click here
