| Full name: metallothionein 1A | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16q13 | ||
| Entrez ID: 4489 | HGNC ID: HGNC:7393 | Ensembl Gene: ENSG00000205362 | OMIM ID: 156350 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MT1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | MT1A | 4489 | 65580 | -1.9422 | 0.0000 | |
| GSE53624 | MT1A | 4489 | 65580 | -1.6232 | 0.0000 | |
| GSE97050 | MT1A | 4489 | A_23_P54840 | -0.3391 | 0.4566 | |
| SRP064894 | MT1A | 4489 | RNAseq | -2.3665 | 0.0014 | |
| SRP159526 | MT1A | 4489 | RNAseq | -4.1171 | 0.0000 | |
| SRP219564 | MT1A | 4489 | RNAseq | -2.0170 | 0.0836 | |
| TCGA | MT1A | 4489 | RNAseq | -2.6866 | 0.0011 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by MT1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MT1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MT1A | 4489 | 5 | 0 | 25 | |
| GSE20123 | MT1A | 4489 | 5 | 1 | 24 | |
| GSE43470 | MT1A | 4489 | 2 | 7 | 34 | |
| GSE46452 | MT1A | 4489 | 38 | 1 | 20 | |
| GSE47630 | MT1A | 4489 | 10 | 8 | 22 | |
| GSE54993 | MT1A | 4489 | 2 | 4 | 64 | |
| GSE54994 | MT1A | 4489 | 7 | 10 | 36 | |
| GSE60625 | MT1A | 4489 | 4 | 0 | 7 | |
| GSE74703 | MT1A | 4489 | 2 | 4 | 30 | |
| GSE74704 | MT1A | 4489 | 4 | 0 | 16 | |
| TCGA | MT1A | 4489 | 25 | 12 | 59 |
Total number of gains: 104; Total number of losses: 47; Total Number of normals: 337.
Somatic mutations of MT1A:
Generating mutation plots.
Highly correlated genes for MT1A:
Showing top 20/28 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MT1A | MT1X | 0.700488 | 4 | 0 | 4 |
| MT1A | MT1E | 0.651948 | 4 | 0 | 3 |
| MT1A | S1PR1 | 0.640434 | 3 | 0 | 3 |
| MT1A | FGD4 | 0.616184 | 3 | 0 | 3 |
| MT1A | ASPA | 0.608354 | 3 | 0 | 3 |
| MT1A | TGFBR3 | 0.604129 | 3 | 0 | 3 |
| MT1A | CH25H | 0.597224 | 3 | 0 | 3 |
| MT1A | KLF9 | 0.596082 | 3 | 0 | 3 |
| MT1A | GNA14 | 0.595525 | 3 | 0 | 3 |
| MT1A | SLC19A2 | 0.594064 | 3 | 0 | 3 |
| MT1A | ABCA8 | 0.594003 | 3 | 0 | 3 |
| MT1A | CLEC3B | 0.593899 | 3 | 0 | 3 |
| MT1A | SLMAP | 0.583691 | 3 | 0 | 3 |
| MT1A | ANGPTL1 | 0.580788 | 3 | 0 | 3 |
| MT1A | AKAP12 | 0.580725 | 3 | 0 | 3 |
| MT1A | GRASP | 0.57825 | 3 | 0 | 3 |
| MT1A | MGLL | 0.578209 | 3 | 0 | 3 |
| MT1A | NFIA | 0.577807 | 3 | 0 | 3 |
| MT1A | CADM3 | 0.565549 | 3 | 0 | 3 |
| MT1A | CAB39L | 0.562688 | 3 | 0 | 3 |
For details and further investigation, click here
