| Full name: muscle associated receptor tyrosine kinase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 9q31.3 | ||
| Entrez ID: 4593 | HGNC ID: HGNC:7525 | Ensembl Gene: ENSG00000030304 | OMIM ID: 601296 |
| Drug and gene relationship at DGIdb | |||
Expression of MUSK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MUSK | 4593 | 207632_at | -0.1820 | 0.2675 | |
| GSE20347 | MUSK | 4593 | 207632_at | -0.0152 | 0.7805 | |
| GSE23400 | MUSK | 4593 | 207633_s_at | -0.0194 | 0.5622 | |
| GSE26886 | MUSK | 4593 | 207632_at | 0.0964 | 0.3499 | |
| GSE29001 | MUSK | 4593 | 207632_at | 0.0396 | 0.7885 | |
| GSE38129 | MUSK | 4593 | 207632_at | -0.0470 | 0.3766 | |
| GSE45670 | MUSK | 4593 | 207632_at | 0.0127 | 0.8788 | |
| GSE53622 | MUSK | 4593 | 103694 | -1.7237 | 0.0000 | |
| GSE53624 | MUSK | 4593 | 103694 | -1.0158 | 0.0000 | |
| GSE63941 | MUSK | 4593 | 207632_at | 0.0565 | 0.7460 | |
| GSE77861 | MUSK | 4593 | 241122_s_at | -0.0551 | 0.5110 | |
| GSE97050 | MUSK | 4593 | A_23_P71649 | -0.0542 | 0.8677 | |
| SRP133303 | MUSK | 4593 | RNAseq | -1.8581 | 0.0000 | |
| SRP159526 | MUSK | 4593 | RNAseq | -0.6988 | 0.2854 | |
| SRP219564 | MUSK | 4593 | RNAseq | -1.1576 | 0.1916 | |
| TCGA | MUSK | 4593 | RNAseq | -2.9242 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by MUSK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MUSK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MUSK | 4593 | 6 | 9 | 15 | |
| GSE20123 | MUSK | 4593 | 6 | 8 | 16 | |
| GSE43470 | MUSK | 4593 | 4 | 3 | 36 | |
| GSE46452 | MUSK | 4593 | 6 | 13 | 40 | |
| GSE47630 | MUSK | 4593 | 3 | 16 | 21 | |
| GSE54993 | MUSK | 4593 | 3 | 3 | 64 | |
| GSE54994 | MUSK | 4593 | 9 | 10 | 34 | |
| GSE60625 | MUSK | 4593 | 0 | 0 | 11 | |
| GSE74703 | MUSK | 4593 | 4 | 3 | 29 | |
| GSE74704 | MUSK | 4593 | 3 | 6 | 11 | |
| TCGA | MUSK | 4593 | 25 | 22 | 49 |
Total number of gains: 69; Total number of losses: 93; Total Number of normals: 326.
Somatic mutations of MUSK:
Generating mutation plots.
Highly correlated genes for MUSK:
Showing top 20/277 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MUSK | CFD | 0.767235 | 3 | 0 | 3 |
| MUSK | NDRG2 | 0.733572 | 3 | 0 | 3 |
| MUSK | FAM107A | 0.724255 | 3 | 0 | 3 |
| MUSK | F10 | 0.714264 | 3 | 0 | 3 |
| MUSK | MGLL | 0.712533 | 3 | 0 | 3 |
| MUSK | RSPO1 | 0.711368 | 3 | 0 | 3 |
| MUSK | SH3BGRL2 | 0.699258 | 3 | 0 | 3 |
| MUSK | TMEM100 | 0.697745 | 3 | 0 | 3 |
| MUSK | MMRN1 | 0.688397 | 3 | 0 | 3 |
| MUSK | C9orf152 | 0.679793 | 3 | 0 | 3 |
| MUSK | KCNAB1 | 0.678825 | 3 | 0 | 3 |
| MUSK | PLAC9 | 0.675804 | 3 | 0 | 3 |
| MUSK | ZNF536 | 0.673952 | 4 | 0 | 4 |
| MUSK | UTRN | 0.673822 | 3 | 0 | 3 |
| MUSK | GREM2 | 0.67127 | 3 | 0 | 3 |
| MUSK | ALDH3A2 | 0.670712 | 3 | 0 | 3 |
| MUSK | AR | 0.669374 | 3 | 0 | 3 |
| MUSK | KIF25 | 0.665383 | 3 | 0 | 3 |
| MUSK | MGST2 | 0.664546 | 3 | 0 | 3 |
| MUSK | CTTNBP2 | 0.663598 | 3 | 0 | 3 |
For details and further investigation, click here
