| Full name: NIMA related kinase 10 | Alias Symbol: FLJ32685 | ||
| Type: protein-coding gene | Cytoband: 3p24.1 | ||
| Entrez ID: 152110 | HGNC ID: HGNC:18592 | Ensembl Gene: ENSG00000163491 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of NEK10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NEK10 | 152110 | 237227_at | 0.0327 | 0.9233 | |
| GSE26886 | NEK10 | 152110 | 237227_at | 0.3607 | 0.0016 | |
| GSE45670 | NEK10 | 152110 | 237227_at | -0.3258 | 0.0110 | |
| GSE53622 | NEK10 | 152110 | 32871 | -1.2618 | 0.0000 | |
| GSE53624 | NEK10 | 152110 | 32871 | -1.5733 | 0.0000 | |
| GSE63941 | NEK10 | 152110 | 237227_at | -2.2146 | 0.0000 | |
| GSE77861 | NEK10 | 152110 | 237227_at | -0.1243 | 0.1721 | |
| GSE97050 | NEK10 | 152110 | A_33_P3422213 | -0.0234 | 0.9119 | |
| SRP133303 | NEK10 | 152110 | RNAseq | -0.3847 | 0.0783 | |
| SRP159526 | NEK10 | 152110 | RNAseq | -1.0575 | 0.0541 | |
| SRP193095 | NEK10 | 152110 | RNAseq | -0.0626 | 0.7925 | |
| SRP219564 | NEK10 | 152110 | RNAseq | -1.2272 | 0.0982 | |
| TCGA | NEK10 | 152110 | RNAseq | -1.8904 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by NEK10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NEK10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NEK10 | 152110 | 0 | 18 | 12 | |
| GSE20123 | NEK10 | 152110 | 0 | 18 | 12 | |
| GSE43470 | NEK10 | 152110 | 0 | 20 | 23 | |
| GSE46452 | NEK10 | 152110 | 2 | 17 | 40 | |
| GSE47630 | NEK10 | 152110 | 1 | 24 | 15 | |
| GSE54993 | NEK10 | 152110 | 6 | 2 | 62 | |
| GSE54994 | NEK10 | 152110 | 1 | 32 | 20 | |
| GSE60625 | NEK10 | 152110 | 5 | 0 | 6 | |
| GSE74703 | NEK10 | 152110 | 0 | 17 | 19 | |
| GSE74704 | NEK10 | 152110 | 0 | 12 | 8 | |
| TCGA | NEK10 | 152110 | 2 | 68 | 26 |
Total number of gains: 17; Total number of losses: 228; Total Number of normals: 243.
Somatic mutations of NEK10:
Generating mutation plots.
Highly correlated genes for NEK10:
Showing top 20/174 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NEK10 | ZEB2 | 0.735237 | 3 | 0 | 3 |
| NEK10 | S1PR1 | 0.717562 | 3 | 0 | 3 |
| NEK10 | ACOT12 | 0.712598 | 3 | 0 | 3 |
| NEK10 | ZNF536 | 0.697375 | 4 | 0 | 3 |
| NEK10 | EXOSC7 | 0.69725 | 3 | 0 | 3 |
| NEK10 | MYEF2 | 0.697085 | 3 | 0 | 3 |
| NEK10 | PLCXD3 | 0.691828 | 3 | 0 | 3 |
| NEK10 | PRDM8 | 0.686257 | 4 | 0 | 4 |
| NEK10 | LGI1 | 0.684296 | 3 | 0 | 3 |
| NEK10 | CCDC12 | 0.676615 | 4 | 0 | 3 |
| NEK10 | GREM2 | 0.673072 | 5 | 0 | 4 |
| NEK10 | NEGR1 | 0.671807 | 4 | 0 | 3 |
| NEK10 | ARHGAP6 | 0.668057 | 5 | 0 | 4 |
| NEK10 | IL33 | 0.667456 | 4 | 0 | 4 |
| NEK10 | RSPO2 | 0.666623 | 4 | 0 | 4 |
| NEK10 | F10 | 0.664488 | 5 | 0 | 4 |
| NEK10 | NCOA1 | 0.664189 | 3 | 0 | 3 |
| NEK10 | CCL11 | 0.662152 | 3 | 0 | 3 |
| NEK10 | KMT2D | 0.656947 | 3 | 0 | 3 |
| NEK10 | ACSM1 | 0.65647 | 3 | 0 | 3 |
For details and further investigation, click here
