PRKAA1

 

Full name: protein kinase AMP-activated catalytic subunit alpha 1 Alias Symbol: AMPKa1
Type: protein-coding gene Cytoband: 5p13.1
Entrez ID: 5562 HGNC ID: HGNC:9376 Ensembl Gene: ENSG00000132356 OMIM ID: 602739
Drug and gene relationship at DGIdb

 

PRKAA1 involved pathways:

KEGG pathway Description View
hsa04068FoxO signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04710Circadian rhythm
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)

 

Expression of PRKAA1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRKAA1 5562 225984_at 0.1489 0.5327
GSE20347 PRKAA1 5562 214917_at 0.7793 0.0024
GSE23400 PRKAA1 5562 214917_at 0.2161 0.0000
GSE26886 PRKAA1 5562 225984_at -0.0180 0.9632
GSE29001 PRKAA1 5562 214917_at 0.5903 0.0140
GSE38129 PRKAA1 5562 209799_at 0.4403 0.0038
GSE45670 PRKAA1 5562 225984_at 0.0520 0.8034
GSE53622 PRKAA1 5562 70951 0.1966 0.0043
GSE53624 PRKAA1 5562 70951 0.2394 0.0021
GSE63941 PRKAA1 5562 209799_at 1.4362 0.0029
GSE77861 PRKAA1 5562 225984_at 0.6265 0.0423
GSE97050 PRKAA1 5562 A_33_P3312212 -0.0057 0.9816
SRP007169 PRKAA1 5562 RNAseq 0.8008 0.0611
SRP008496 PRKAA1 5562 RNAseq 0.7404 0.0102
SRP064894 PRKAA1 5562 RNAseq -0.0391 0.8834
SRP133303 PRKAA1 5562 RNAseq 0.2172 0.1278
SRP159526 PRKAA1 5562 RNAseq 0.2122 0.5866
SRP193095 PRKAA1 5562 RNAseq 0.0128 0.9205
SRP219564 PRKAA1 5562 RNAseq -0.1061 0.7181
TCGA PRKAA1 5562 RNAseq -0.1035 0.0501

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by PRKAA1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRKAA1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRKAA1 5562 9 0 21
GSE20123 PRKAA1 5562 9 0 21
GSE43470 PRKAA1 5562 17 0 26
GSE46452 PRKAA1 5562 5 22 32
GSE47630 PRKAA1 5562 6 12 22
GSE54993 PRKAA1 5562 5 4 61
GSE54994 PRKAA1 5562 24 2 27
GSE60625 PRKAA1 5562 0 0 11
GSE74703 PRKAA1 5562 13 0 23
GSE74704 PRKAA1 5562 8 0 12
TCGA PRKAA1 5562 53 6 37

Total number of gains: 149; Total number of losses: 46; Total Number of normals: 293.  

 

Somatic mutations of PRKAA1:

 

Generating mutation plots.

 

Highly correlated genes for PRKAA1:

 

Showing top 20/530 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRKAA1RNF1450.717458303
PRKAA1TMCO60.712663303
PRKAA1PAK20.709334303
PRKAA1LDHA0.698609303
PRKAA1PRPF4B0.689803303
PRKAA1FAM3C0.68369404
PRKAA1DHX380.682811303
PRKAA1SLC45A40.680472303
PRKAA1CEP1200.679081303
PRKAA1ZNF518B0.672683303
PRKAA1GEN10.671976303
PRKAA1ERGIC30.671673404
PRKAA1PPTC70.671025403
PRKAA1NEK60.670937404
PRKAA1SASS60.66419403
PRKAA1SRRT0.664076403
PRKAA1TMEM2090.660113403
PRKAA1BIRC20.659894504
PRKAA1MAP3K130.659789403
PRKAA1MED300.657653404

For details and further investigation, click here