| Full name: phosphoenolpyruvate carboxykinase 1 | Alias Symbol: PEPCK-C | ||
| Type: protein-coding gene | Cytoband: 20q13.31 | ||
| Entrez ID: 5105 | HGNC ID: HGNC:8724 | Ensembl Gene: ENSG00000124253 | OMIM ID: 614168 |
PCK1 involved pathways:
Expression of PCK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PCK1 | 5105 | 208383_s_at | -2.0634 | 0.0854 | |
| GSE20347 | PCK1 | 5105 | 208383_s_at | -0.0947 | 0.4497 | |
| GSE23400 | PCK1 | 5105 | 208383_s_at | -0.0512 | 0.0031 | |
| GSE26886 | PCK1 | 5105 | 208383_s_at | -0.0765 | 0.7081 | |
| GSE29001 | PCK1 | 5105 | 208383_s_at | -0.3180 | 0.0551 | |
| GSE38129 | PCK1 | 5105 | 208383_s_at | -0.4525 | 0.1183 | |
| GSE45670 | PCK1 | 5105 | 208383_s_at | -0.4468 | 0.0235 | |
| GSE53622 | PCK1 | 5105 | 13457 | -0.7935 | 0.0000 | |
| GSE53624 | PCK1 | 5105 | 13457 | -1.2253 | 0.0000 | |
| GSE63941 | PCK1 | 5105 | 208383_s_at | 0.1332 | 0.8811 | |
| GSE77861 | PCK1 | 5105 | 208383_s_at | 0.0103 | 0.9112 | |
| SRP133303 | PCK1 | 5105 | RNAseq | -0.3596 | 0.1942 | |
| SRP193095 | PCK1 | 5105 | RNAseq | -0.5889 | 0.0685 | |
| TCGA | PCK1 | 5105 | RNAseq | -1.1357 | 0.0904 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PCK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PCK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PCK1 | 5105 | 14 | 2 | 14 | |
| GSE20123 | PCK1 | 5105 | 14 | 2 | 14 | |
| GSE43470 | PCK1 | 5105 | 13 | 0 | 30 | |
| GSE46452 | PCK1 | 5105 | 29 | 0 | 30 | |
| GSE47630 | PCK1 | 5105 | 24 | 1 | 15 | |
| GSE54993 | PCK1 | 5105 | 0 | 17 | 53 | |
| GSE54994 | PCK1 | 5105 | 29 | 0 | 24 | |
| GSE60625 | PCK1 | 5105 | 0 | 0 | 11 | |
| GSE74703 | PCK1 | 5105 | 11 | 0 | 25 | |
| GSE74704 | PCK1 | 5105 | 11 | 0 | 9 | |
| TCGA | PCK1 | 5105 | 43 | 4 | 49 |
Total number of gains: 188; Total number of losses: 26; Total Number of normals: 274.
Somatic mutations of PCK1:
Generating mutation plots.
Highly correlated genes for PCK1:
Showing top 20/36 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PCK1 | NIPSNAP3B | 0.669778 | 4 | 0 | 3 |
| PCK1 | ALDH8A1 | 0.666849 | 3 | 0 | 3 |
| PCK1 | ESRRG | 0.659968 | 3 | 0 | 3 |
| PCK1 | NR4A1 | 0.64867 | 3 | 0 | 3 |
| PCK1 | TAC1 | 0.644507 | 4 | 0 | 3 |
| PCK1 | PRKAA2 | 0.629632 | 4 | 0 | 4 |
| PCK1 | CKMT2 | 0.612724 | 4 | 0 | 3 |
| PCK1 | MT1M | 0.597905 | 3 | 0 | 3 |
| PCK1 | GDF10 | 0.588201 | 4 | 0 | 3 |
| PCK1 | AK9 | 0.577704 | 4 | 0 | 3 |
| PCK1 | TMEM178A | 0.576813 | 3 | 0 | 3 |
| PCK1 | TFAP2B | 0.569146 | 5 | 0 | 3 |
| PCK1 | F10 | 0.565012 | 4 | 0 | 3 |
| PCK1 | NR4A2 | 0.562899 | 4 | 0 | 3 |
| PCK1 | KCTD6 | 0.55968 | 4 | 0 | 3 |
| PCK1 | STK32A | 0.554728 | 4 | 0 | 3 |
| PCK1 | COBL | 0.549066 | 6 | 0 | 4 |
| PCK1 | SLC27A6 | 0.540205 | 5 | 0 | 3 |
| PCK1 | RSPO1 | 0.536889 | 5 | 0 | 3 |
| PCK1 | ZNF536 | 0.533718 | 5 | 0 | 3 |
For details and further investigation, click here
