| Full name: procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 | Alias Symbol: LH2 | ||
| Type: protein-coding gene | Cytoband: 3q24 | ||
| Entrez ID: 5352 | HGNC ID: HGNC:9082 | Ensembl Gene: ENSG00000152952 | OMIM ID: 601865 |
| Drug and gene relationship at DGIdb | |||
Expression of PLOD2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLOD2 | 5352 | 202620_s_at | 0.5856 | 0.2735 | |
| GSE20347 | PLOD2 | 5352 | 202620_s_at | 0.8670 | 0.0004 | |
| GSE23400 | PLOD2 | 5352 | 202619_s_at | 1.0740 | 0.0000 | |
| GSE26886 | PLOD2 | 5352 | 202620_s_at | 0.3973 | 0.3925 | |
| GSE29001 | PLOD2 | 5352 | 202620_s_at | 0.8356 | 0.0010 | |
| GSE38129 | PLOD2 | 5352 | 202620_s_at | 0.6926 | 0.0005 | |
| GSE45670 | PLOD2 | 5352 | 202620_s_at | 0.5346 | 0.0421 | |
| GSE53622 | PLOD2 | 5352 | 25779 | 1.1570 | 0.0000 | |
| GSE53624 | PLOD2 | 5352 | 25779 | 1.1840 | 0.0000 | |
| GSE63941 | PLOD2 | 5352 | 202620_s_at | -2.2075 | 0.1121 | |
| GSE77861 | PLOD2 | 5352 | 202620_s_at | 0.3699 | 0.5199 | |
| GSE97050 | PLOD2 | 5352 | A_33_P3318581 | 0.5710 | 0.1832 | |
| SRP007169 | PLOD2 | 5352 | RNAseq | 1.6199 | 0.0002 | |
| SRP008496 | PLOD2 | 5352 | RNAseq | 1.5975 | 0.0000 | |
| SRP064894 | PLOD2 | 5352 | RNAseq | 1.3731 | 0.0000 | |
| SRP133303 | PLOD2 | 5352 | RNAseq | 1.6606 | 0.0000 | |
| SRP159526 | PLOD2 | 5352 | RNAseq | 0.8219 | 0.0064 | |
| SRP193095 | PLOD2 | 5352 | RNAseq | 0.9057 | 0.0000 | |
| SRP219564 | PLOD2 | 5352 | RNAseq | 0.9724 | 0.0642 | |
| TCGA | PLOD2 | 5352 | RNAseq | 0.1333 | 0.1293 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by PLOD2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLOD2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLOD2 | 5352 | 22 | 0 | 8 | |
| GSE20123 | PLOD2 | 5352 | 22 | 0 | 8 | |
| GSE43470 | PLOD2 | 5352 | 23 | 0 | 20 | |
| GSE46452 | PLOD2 | 5352 | 16 | 3 | 40 | |
| GSE47630 | PLOD2 | 5352 | 19 | 3 | 18 | |
| GSE54993 | PLOD2 | 5352 | 1 | 9 | 60 | |
| GSE54994 | PLOD2 | 5352 | 34 | 1 | 18 | |
| GSE60625 | PLOD2 | 5352 | 0 | 6 | 5 | |
| GSE74703 | PLOD2 | 5352 | 20 | 0 | 16 | |
| GSE74704 | PLOD2 | 5352 | 15 | 0 | 5 | |
| TCGA | PLOD2 | 5352 | 66 | 2 | 28 |
Total number of gains: 238; Total number of losses: 24; Total Number of normals: 226.
Somatic mutations of PLOD2:
Generating mutation plots.
Highly correlated genes for PLOD2:
Showing top 20/706 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLOD2 | FADS1 | 0.705489 | 3 | 0 | 3 |
| PLOD2 | FRMD6-AS1 | 0.663057 | 3 | 0 | 3 |
| PLOD2 | GNG10 | 0.65836 | 3 | 0 | 3 |
| PLOD2 | GPRIN1 | 0.657948 | 3 | 0 | 3 |
| PLOD2 | GPX8 | 0.654626 | 7 | 0 | 7 |
| PLOD2 | LOXL2 | 0.654589 | 12 | 0 | 12 |
| PLOD2 | EPYC | 0.651626 | 3 | 0 | 3 |
| PLOD2 | SNAP47 | 0.650973 | 3 | 0 | 3 |
| PLOD2 | SERPINH1 | 0.64924 | 10 | 0 | 9 |
| PLOD2 | PYCR2 | 0.646316 | 3 | 0 | 3 |
| PLOD2 | FNDC3B | 0.645293 | 13 | 0 | 11 |
| PLOD2 | GXYLT2 | 0.643713 | 6 | 0 | 6 |
| PLOD2 | MFAP2 | 0.643116 | 12 | 0 | 10 |
| PLOD2 | SPON2 | 0.640557 | 3 | 0 | 3 |
| PLOD2 | MSANTD3 | 0.640371 | 4 | 0 | 3 |
| PLOD2 | SLC19A1 | 0.63932 | 3 | 0 | 3 |
| PLOD2 | CNTROB | 0.635722 | 4 | 0 | 3 |
| PLOD2 | CEP170 | 0.632952 | 3 | 0 | 3 |
| PLOD2 | NREP | 0.632307 | 9 | 0 | 8 |
| PLOD2 | TGFBI | 0.628333 | 13 | 0 | 11 |
For details and further investigation, click here
